crk
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  • Official Full Name
  • v-crk sarcoma virus CT10 oncogene homolog (avian)
  • Background
  • CrkII, a cellular homologue of v-Crk, belongs to a family of adaptor proteins with an SH2-SH3-SH3 domain structure that transmits signals from tyrosine kinases. The primary function of Crk is to recruit cytoplasmic proteins in the vicinity of tyrosine kin
  • Synonyms
  • CRK; v-crk sarcoma virus CT10 oncogene homolog (avian); v crk avian sarcoma virus CT10 oncogene homolog; adapter molecule crk; proto-oncogene c-Crk; p38; CRKII; FLJ38130
Cat.#:CRK-1886HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CRK Protein, GST-tagged
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Cat.#:CRK-11582HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRK, GST-tagged
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Cat.#:CRK-27823THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRK, His-tagged
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Cat.#:CRK-1603RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CRK Protein
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Cat.#:CRK-1771CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CRK
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Cat.#:CRK-1053ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CRK
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Cat.#:CRK-2854HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRK, His-tagged
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Cat.#:CRK-7276HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CRK 293 Cell Lysate
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Cat.#:CRK-7277HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CRK 293 Cell Lysate
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Involved Pathway

CRK involved in several pathways and played different roles in them. We selected most pathways CRK participated on our site, such as ARMS-mediated activation, Angiopoietin receptor Tie2-mediated signaling, B Cell Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
PHB; WDR83; PTPRA; MARK3; FRS2B; CSF2; DLG4; PSMD5; SPNA2; SPRED3
Angiopoietin receptor Tie2-mediated signaling
ELF2; GRB7; ELF1; AGTR1; CDKN1A; DOK2; CRK; BMX; GRB14
B Cell Receptor Signaling Pathway
PPP3CC; PDK2; NFATC3; RELA; ARPC1B; HRAS; PIK3R1; BCL10; VAV1; FCGR2B
Bacterial invasion of epithelial cells
CTNNA2; ARPC3; HCLS1; SHC1; PIK3CD; CTNNA1; ITGB1; CRKL; SEPT12; SEPT11
CXCR4-mediated signaling events
GNB2L1; GNA13; JAK2; ADRBK1; MAPKAP1; PAG1; DNM1; ARR3; CRK; CFL1
Chemokine signaling pathway
GRB2; AMCF-II; CCL3L3; AKT1; GRK1; ARRB1; GNGT1; CXCL9; CCL4; SHC4
Chronic myeloid leukemia
CCND1; NFKBIA; CDK6; MAP2K1; HDAC1; PIK3CB; GAB2; RAF1; CBLB; PIK3R2
Cytokine Signaling in Immune system
OASL; HAVCR2; FGF10B; SAMHD1; NRG4; CRK; SOCS3A; FRS2A; SPTBN2; TRIM17

Protein Function

CRK has several biochemical functions, for example, SH2 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRK itself. We selected most functions CRK had, and list some proteins which have the same functions with CRK. You can find most of the proteins on our site.
Function
Related Protein
Function SH2 domain binding
Related Protein KHDRBS2; SHCBP1; PTK2; SRC; TRPV4; DLC1; NLK; LAT2; PAG1; SIT1
Function SH3/SH2 adaptor activity
Related Protein SH2D2A; SHB; SRC; PAG1; ARHGAP4; SOCS2; EPS8; SLA2; SKAP2; ARHGAP1
Function ephrin receptor binding
Related Protein EFNA5; SIPA1L1; CBL; EFNB3; CHN1; EFNA3; EFNA1; EFNA2A; EFNB1; PIK3CG
Function protein binding
Related Protein LUZP4; ARF6; ERCC3; AMBRA1; DCDC2; STBD1; PIK3C3; CSPG5; CRHBP; LMX1B
Function protein phosphorylated amino acid binding
Related Protein BTRC; ARRB1; CRK

Interacting Protein

CRK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRK here. Most of them are supplied by our site. Hope this information will be useful for your research of CRK.
CBL; BCAR1; PDGFRA; ABL2

CRK Related Articles

Li, J; Chen, S; et al. Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 307:C288-C295(2014).
Aten, TM; Redmond, MM; et al. Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL. FEBS LETTERS 587:2313-2318(2013).