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CSH1

  • Official Full Name

    chorionic somatomammotropin hormone 1 (placental lactogen)

  • Overview

    The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
  • Synonyms

    CSH1; chorionic somatomammotropin hormone 1 (placental lactogen); chorionic somatomammotropin hormone; choriomammotropin; chorionic somatomammotropin A; CSA; CSMT; FLJ75407; hCS A; PL; placental lactogen; CS-1; hCS-A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Rhesus Macaque
  • Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect cells
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CSH1-1976H Recombinant Human CSH1 Protein, GST-tagged Wheat Germ GST
Human CSH1-346H Recombinant Human Chorionic Somatomammotropin Hormone 1 (placental lactogen) E.coli N/A
Human CSH1-203H Recombinant Human CSH1 protein, His-tagged HEK293 His Met1-Phe217
Human CSH1-184H Recombinant Human Placental Lactogen E.coli N/A
Human CSH1-2206HCL Recombinant Human CSH1 cell lysate Human Cell N/A
Human CSH1-185H Human Placental Lactogen Reference standard N/A
Human CSH1-31024TH Native Human CSH1 N/A 191 amino acids
Human CSH1-037H Active Recombinant Human CSH1 Protein, His-tagged Insect cells His
Human CSH1-3346H Recombinant Human CSH1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CSH1-2743H Recombinant Human CSH1 protein, His-tagged E.coli His 27-217aa
Human CSH1-007H Active Recombinant Human CSH1 Protein, His-tagged Insect Cells His 27-217aa
Human CSH1-2176HF Recombinant Full Length Human CSH1 Protein, GST-tagged In Vitro Cell Free System GST 217 amino acids
Human CSH1-5313H Recombinant Human CSH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CSH1-1831H Recombinant Human CSH1 Protein (Gln28-Arg193), N-His tagged E.coli N-His Gln28-Arg193
Human CSH1-1832H Recombinant Human CSH1 Protein (Val27-Phe217), C-His tagged Mammalian cells C-His Val27-Phe217
Human CSH1-2183H Recombinant Human CSH1 protein, His-tagged, Biotinylated HEK293 His Met1-Phe217
Bovine CSH1-50B Recombinant Bovine Chorionic Somatomammotropin Hormone 1 E.coli N/A
Rhesus Macaque CSH1-1053R Recombinant Rhesus monkey CSH1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CSH1-878R Recombinant Rhesus Macaque CSH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CSH1-878R-B Recombinant Rhesus Macaque CSH1 Protein Pre-coupled Magnetic Beads HEK293
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RFL28207SF Recombinant Full Length Saccharomyces Cerevisiae Mannosyl Phosphorylinositol Ceramide Synthase Csh1(Csh1) Protein, His-Tagged E.coli expression system His Full Length (1-376)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CSH1 Related Research Area

CSH1 involved in several pathways and played different roles in them. We selected most pathways CSH1 participated on our site, such as Cytokine Signaling in Immune system, Growth hormone receptor signaling, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine Signaling in Immune systemMX2;CSH1;CISH;PHB;DUSP5;PAQR3B;CSF2;SPTB;FRS2
Growth hormone receptor signalingCSHL1;GHRB;CSH1;CISH;PRLRB
Immune SystemNLRC5;FBXO17;PJA2;ERAP1;XAF1;IFI30;BTR02;BLMH;GZMM
Jak-STAT signaling pathwayGHRA;IFNG;IL12RB2;IFNA1;CNTF;IL2RA;IL-15RA;PIAS4B;STAM
Neuroactive ligand-receptor interactionGABRP;P2RX1;SCTR;BRS3;ADRB2B;CHRNA10;GRIK4;F2RL1.1;TAAR10B
Nuclear signaling by ERBB4WWOX;GHRB;YAP1;PRLRB;CSN2;CSHL1;CSH1
PI3K-Akt signaling pathwaySGK2;CSH2;CSF3;CSH;CSF1R;CHAD;CSF1;LAMC3;CSF3R
Prolactin receptor signalingCSH1;GHRB;CSHL1;PRLRB

CSH1 has several biochemical functions, for example, hormone activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSH1 itself. We selected most functions CSH1 had, and list some proteins which have the same functions with CSH1. You can find most of the proteins on our site.

Function Related Protein
hormone activityUTS2D;AGT;EDN3;INHBAB;LRSAM1;INHBC;ADM;GH1;PRL2C2
metal ion bindingRPP21;ZBTB3;MINA;EPT1;ATF7B;ZFP541;HGS;ASAP2B;SCNM1-PS

CSH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSH1.

SMAD9; PTPN12; SMAD4; SMAD2

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