cstf3
Share
  • Official Full Name
  • cleavage stimulation factor, 3 pre-RNA, subunit 3, 77kDa
  • Background
  • The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3 end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms
  • CSTF3; cleavage stimulation factor, 3 pre-RNA, subunit 3, 77kDa; cleavage stimulation factor, 3 pre RNA, subunit 3, 77kD; cleavage stimulation factor subunit 3; CstF 77; CF-1 77 kDa subunit; CSTF 77 kDa subunit; cleavage stimulation factor 77 kDa subunit
Cat.#:CSTF3-2044HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CSTF3 Protein, GST-tagged
+Inquiry
Cat.#:CSTF3-11652HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSTF3, GST-tagged
+Inquiry
Cat.#:CSTF3-1072RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CSTF3 Protein, His-tagged
+Inquiry
Cat.#:CSTF3-1940CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CSTF3
+Inquiry
Cat.#:CSTF3-12288ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CSTF3
+Inquiry
Cat.#:CSTF3-7222HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CSTF3 293 Cell Lysate
+Inquiry

Involved Pathway

CSTF3 involved in several pathways and played different roles in them. We selected most pathways CSTF3 participated on our site, such as Cleavage of Growing Transcript in the Termination Region, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSTF3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cleavage of Growing Transcript in the Termination Region
LSM10; PAPOLA; ZNF473; ZFP473; THOC4; U2AF2; CSTF2; CSTF1; SLBP; LSM11
Gene Expression
ZNF253; EEF2; TSEN2; ZNF571; ZNF317; EIF2S3; PTBP1A; TTC6; TEAD1A; ZNF473
Processing of Capped Intron-Containing Pre-mRNA
TTC6; SNRNP25; METTL14; SF3A1; U2AF2; BCAS2; HNRNPA0A; CSTF3; PCBP2; RNPC3
Processing of Capped Intronless Pre-mRNA
SLBP; LSM10; CSTF1; CLP1; CSTF3; ZFP473; ZNF473; NUDT21; LSM11; PAPOLA
Processing of Intronless Pre-mRNAs
CSTF1; NUDT21; CSTF2; PAPOLA; CLP1; CSTF3
RNA Polymerase II Transcription
CSTF1; CSTF3; SRSF11; NUDT21; CCNT2B; U2AF2; ZFP473; PAPOLA; ZNF473; THOC4
RNA Polymerase II Transcription Termination
ZNF473; ZFP473; LSM11; PAPOLA; SLBP; LSM10; CSTF2; NUDT21; CLP1; RNPS1
mRNA 3-end processing
CSTF2; NUDT21; SFRS3A; CSTF3; CLP1; SRSF11

Protein Function

CSTF3 has several biochemical functions, for example, RNA binding, mRNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSTF3 itself. We selected most functions CSTF3 had, and list some proteins which have the same functions with CSTF3. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein U2AF2A; Akap17b; THOC1; PRPF6; HNRNPA1L2; NABP1; EIF4E2RS1; EIF2C3; RDBP; CAPRIN2
Function mRNA binding
Related Protein FXR2; EIF4A1; CELF3; SNRNP70; NANOS2; EIF4A3; NUDT21; RBM38; FMR1; MECP2
Function poly(A) RNA binding
Related Protein TTC6; RPS21; ACTN4; TRMT10C; MOV10; PUM1; EIF4E2; DDX47; SNRPB; HNRNPK
Function protein binding
Related Protein NXF2; CRLF3; GRB2; AP5S1; NR1I2; LSM2; BMX; C12orf43; AGGF1; TFF2

Interacting Protein

CSTF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSTF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSTF3.
CDK4; VHL; IKBKE; emrR; 15-deoxy-delta(12,14; ssrna_ug; NPM1; SNW1; RNPS1; FIP1L1; Myh9