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CTCF

Official Full Name

CCCTC-binding factor (zinc finger protein)
Overview

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Synonyms

CTCF; CCCTC-binding factor (zinc finger protein); MRD21; transcriptional repressor CTCF; CTCFL paralog; 11-zinc finger protein; 11 zinc finger transcriptional repressor;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N
Tag Free

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CTCF-26436TH	Recombinant Human CTCF	Wheat Germ	N/A	100 amino acids	Inquiry
Human	CTCF-15H	Recombinant Human CTCF protein	E.coli	N/A		Inquiry
Human	CTCF-16H	Recombinant Human CTCF protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CTCF-7213HCL	Recombinant Human CTCF 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CTCF-730HF	Recombinant Full Length Human CTCF Protein, GST-tagged	In Vitro Cell Free System	GST	727 amino acids	Inquiry
Human	CTCF-2364H	Recombinant Human CTCF protein, His-tagged	E.coli	His	266-727aa	Inquiry
Human	CTCF-1699H	Recombinant Human CTCF Protein (Met1-Ile154), N-His tagged	E.coli	N-His	Met1-Ile154	Inquiry
Human	CTCF-1700H	Recombinant Human CTCF Protein (Met1-Ile154)	E.coli	Tag Free	Met1-Ile154	Inquiry
Mouse	CTCF-4013M	Recombinant Mouse CTCF Protein	Mammalian Cell	His		Inquiry
Mouse	CTCF-2043M	Recombinant Mouse CTCF Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	CTCF-2043M-B	Recombinant Mouse CTCF Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	CTCF-1651R	Recombinant Rat CTCF Protein	Mammalian Cell	His		Inquiry
Rat	CTCF-1310R	Recombinant Rat CTCF Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CTCF-1310R-B	Recombinant Rat CTCF Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	CTCF-253Z	Recombinant Zebrafish CTCF	Mammalian Cell	His		Inquiry
Chicken	CTCF-6884C	Recombinant Chicken CTCF	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CTCF Related Articles

CTCF involved in several pathways and played different roles in them. We selected most pathways CTCF participated on our site, such as SIDS Susceptibility Pathways, TGF-beta Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTCF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
SIDS Susceptibility Pathways	CTCF;KCNQ1;CC2D1A;EN1;SST;CDCA7L;POU3F2;ECE1;SCN3B
TGF-beta Receptor Signaling Pathway	HOXD9A;STK11IP;DAB2;RUNX2A;NFYBB;STRAP;MEF2AA;COPS5;CTCF

CTCF has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin insulator sequence binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTCF itself. We selected most functions CTCF had, and list some proteins which have the same functions with CTCF. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	RFX4;CTCFL;JUNBB;SREBF2;ASCL1;TCF12;IFI203;HHEX;SIX2
chromatin insulator sequence binding
protein binding	APOA2;FAF2;GORAB;TMEM41A;KRT81;PARVG;ZBTB17;SOCS5;SURF1
sequence-specific DNA binding	NR5A2;EOMES;HOXC9;ZFP536;RBPJ;NR2F1A;AHR2;GATAD1;AHR
transcription corepressor activity	TLE2;ARHGAP35;AES;BRD7;E2F7;BASP1;CCND1;ALX1;TGIF1
transcription factor activity, sequence-specific DNA binding	IKZF4;POU4F1;ZNF584;KDM1A;FOXE3;RORA;ZNF789;NR1D2A;TCF7L1B
transcription regulatory region DNA binding	CDK5RAP2;GATA5;BRCA1;ZNF649;RNF10;NR5A2;TAF2;TBL1X;ZFP746
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	FEZF2;CREB3L4;MYF6;MAF;CREBBP;CSRNP2;FOXO3;MAFK;TP53
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	ZBTB7A;NKX6;TCF21;MLXIPL;DACH1;BCL11A;SP3;NFIL3-4;TCF3
zinc ion binding	ADAM12;ZFP346;PCGF5A;BTY;ZCCHC2;Npepo;LIMA1;LDB3;LMO7B

CTCF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTCF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTCF.

HDLBP; ZMYM4; KDM5B; mdm2_human_probe; CHD8

Lin, SG; Guo, CG; et al. CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:1815-1820(2015).

Batlle-Lopez, A; Cortiguera, MG; et al. Novel CTCF binding at a site in exon1A of BCL6 is associated with active histone marks and a transcriptionally active locus. ONCOGENE 34:246-256(2015).