CTNS
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Official Full Name
cystinosin, lysosomal cystine transporter
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Overview
This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. -
Synonyms
CTNS; cystinosin, lysosomal cystine transporter; cystinosis, nephropathic; cystinosin; CTNS LSB; PQLC4; CTNS-LSB;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Dictyostelium discoideum (Slime mold)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CTNS-2090H | Recombinant Human CTNS Protein, GST-tagged | Wheat Germ | GST |
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| Human | CTNS-7199HCL | Recombinant Human CTNS 293 Cell Lysate | HEK293 | N/A |
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| Human | CTNS-7198HCL | Recombinant Human CTNS 293 Cell Lysate | HEK293 | N/A |
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| Human | CTNS-2320HF | Recombinant Full Length Human CTNS Protein, GST-tagged | In Vitro Cell Free System | GST | 400 amino acids |
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| Human | CTNS-2091H | Recombinant Human CTNS Protein, MYC/DDK-tagged | HEK293T | MYC/DDK |
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| Human | CTNS-4113H | Recombinant Human CTNS Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | CTNS-1290H | Recombinant Human CTNS Protein, His-tagged | E.coli | N-His | Pro30-Phe170 |
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| Mouse | CTNS-4037M | Recombinant Mouse CTNS Protein | Mammalian Cell | His |
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| Mouse | Ctns-2363M | Recombinant Mouse Ctns Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Mouse | Ctns-01M | Recombinant Mouse Ctns Protein, MYC/DDK-tagged | HEK293T | MYC/DDK |
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| Mouse | CTNS-2059M | Recombinant Mouse CTNS Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | CTNS-2059M-B | Recombinant Mouse CTNS Protein Pre-coupled Magnetic Beads | HEK293 |
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| Bos taurus (Bovine) | RFL34031BF | Recombinant Full Length Bovine Cystinosin(Ctns) Protein, His-Tagged | E.coli expression system | His | Full Length (1-367) |
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| Dictyostelium discoideum (Slime mold) | RFL9063DF | Recombinant Full Length Dictyostelium Discoideum Cystinosin Homolog(Ctns) Protein, His-Tagged | E.coli expression system | His | Full Length (1-284) |
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| Homo sapiens (Human) | RFL9485HF | Recombinant Full Length Human Cystinosin(Ctns) Protein, His-Tagged | E.coli expression system | His | Full Length (1-367) |
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| Mus musculus (Mouse) | RFL34696MF | Recombinant Full Length Mouse Cystinosin(Ctns) Protein, His-Tagged | E.coli expression system | His | Full Length (1-367) |
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| Zebrafish | CTNS-2754Z | Recombinant Zebrafish CTNS | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- CTNS Related Articles
CTNS involved in several pathways and played different roles in them. We selected most pathways CTNS participated on our site, such as Lysosome, Miscellaneous transport and binding events, SLC-mediated transmembrane transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTNS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | DNASE2B;AP1G2;SORT1B;IDUA;ATP6AP1;ABCB9;MCOLN1;SMPD1;AP1M1 |
| Miscellaneous transport and binding events | ADD3A;DMTN;PIP;AZGP1;CTNS;MRS2;ADD2;ADD3B;ANKHA |
| SLC-mediated transmembrane transport | SLC39A3;SLC15A3;SLC24A4A;SLC2A12;SLC30A2;SLC3A2A;SLC7A3A;SLC36A2;SLC13A5A |
| Transmembrane transport of small molecules | SLCO2B1;SLC3A2B;ADD3;ATP2C1;SLC12A1;SLC13A2;AQP6;BEST4;SGK2 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | SLC12A5B;SLC26A7;SLC9A7;SLC15A3;SLC15A1B;CTNS;SLC4A3;SLC7A11;SLC4A1B |
CTNS has several biochemical functions, for example, L-cystine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTNS itself. We selected most functions CTNS had, and list some proteins which have the same functions with CTNS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-cystine transmembrane transporter activity | CTNS;SLC3A1;SLC1A4 |
CTNS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTNS here. Most of them are supplied by our site. Hope this information will be useful for your research of CTNS.
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- Reviews
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