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Ctsc

  • Official Full Name

    cathepsin C

  • Overview

    The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CTSC; cathepsin C; PALS, PLS; dipeptidyl peptidase 1; DPP1; AI047818; CATC; Cathepsin J; CPPI; Dipeptidyl transferase; DPP I; DPPI; EC 3.4.14.1; HMS; JP; JPD; MGC126959; PALS; PLS; dipeptidyl peptidase I; dipeptidyl-peptidase I; DPP-I;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTSC-2510H Active Recombinant Human CTSC, His-tagged Mammalian cells His Asp25-Leu463
Human CTSC-2102H Recombinant Human CTSC Protein, GST-tagged Wheat Germ GST
Human CTSC-8178H Recombinant Human CTSC protein, His-tagged E.coli His Leu231~Leu463 (Accession # P53634)
Human CTSC-2509H Active Recombinant Human CTSC protein(Met1-Leu463), His-tagged HEK293 C-His Met1-Leu463
Human CTSC-3024HCL Recombinant Human CTSC cell lysate Human Cell N/A
Human CTSC-4828H Recombinant Human CTSC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CTSC-686H Recombinant Human CTSC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CTSC-2333HF Recombinant Full Length Human CTSC Protein, GST-tagged In Vitro Cell Free System GST 463 amino acids
Human CTSC-3367H Recombinant Human CTSC Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CTSC-1863HFL Recombinant Full Length Human CTSC Protein, C-Flag-tagged Mammalian cells Flag
Human CTSC-686H-B Recombinant Human CTSC Protein Pre-coupled Magnetic Beads HEK293
Mouse CTSC-05M Active Recombinant Mouse CTSC Protein, His-tagged HEK293 His 25-462aa
Mouse CTSC-4048M Recombinant Mouse CTSC Protein Mammalian Cell His
Mouse Ctsc-279M Recombinant Mouse Ctsc, None tagged Human Cell N/A
Mouse Ctsc-8179M Recombinant Mouse Ctsc protein, His-tagged E.coli His Pro231~Leu462 (Accession # P97821)
Mouse Ctsc-2063M Recombinant Mouse Ctsc Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ctsc-2063M-B Recombinant Mouse Ctsc Protein Pre-coupled Magnetic Beads HEK293
Mouse Ctsc-001M Active Recombinant Mouse Ctsc Protein, His-tagged Mammalian cells His
Mouse Ctsc-2368M Recombinant Mouse Ctsc Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CTSC-1663R Recombinant Rat CTSC Protein Mammalian Cell His
Rat CTSC-1322R Recombinant Rat CTSC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CTSC-1322R-B Recombinant Rat CTSC Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey CTSC-428C Recombinant Cynomolgus CTSC Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CTSC-176C-B Recombinant Cynomolgus Monkey CTSC Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey CTSC-176C Recombinant Cynomolgus Monkey CTSC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CTSC-1087R Recombinant Rhesus monkey CTSC Protein, His-tagged Mammalian Cell His
Rhesus Macaque CTSC-912R Recombinant Rhesus Macaque CTSC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CTSC-912R-B Recombinant Rhesus Macaque CTSC Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CTSC-12748Z Recombinant Zebrafish CTSC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ctsc Related Articles
  • Ctsc Related Research Area

Ctsc involved in several pathways and played different roles in them. We selected most pathways Ctsc participated on our site, such as Adaptive Immune System, Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctsc were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemPPIAL4A;B2ML;FBXO17;DNM1;MICA;KIF4;CDKN1A;SPSB2;ARIH2
Asparagine N-linked glycosylationTRAPPC3;GNE;SLC35A1;TRAPPC10;MGAT4A;ST8SIA3;MGAT4B;TFG;SCFD1
COPII (Coat Protein 2) Mediated Vesicle TransportTRAPPC2L;TRAPPC6A;TRAPPC4;CSNK1D;USO1;TRAPPC2;CNIH3;AREG;GOLGA2
Cargo concentration in the ERLMAN2L;MCFD2;CTSZ;SEC24A;AREG;SEC23A;LMAN2;CNIH3;CTSC
ER to Golgi Anterograde TransportCNIH3;NAPAB;TRAPPC6BL;TRAPPC3;SEC22C;SERPINA1L;PPP6C;TRAPPC6A;NAPG
Immune SystemASB13;TRIM11;DEFA6;HAVCR2;CTLA4;TNFRSF13C;LY86;KIF3B;SUGT1
LysosomeATP6V0A2B;PSAPL1;AP3B1;ARSA;IGF2R;FUCA1;CTSSB.1;CTSBA;AP1G2
MHC class II antigen presentationKIF26A;CTSLL;CTSH;DYNC1I1;DCTN6;FAM49BA;MGC174155;CTS7;KIF3B

Ctsc has several biochemical functions, for example, chaperone binding, chloride ion binding, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctsc itself. We selected most functions Ctsc had, and list some proteins which have the same functions with Ctsc. You can find most of the proteins on our site.

Function Related Protein
chaperone bindingDNAJB5;DNAJA3A;FGB;ST13;ERP29;TBCE;CALR;AHSA1L;DNAJB1
chloride ion bindingNLGN4X;SLC22A6;ACE;Amy1;AMY2A;CTSC
cysteine-type endopeptidase activator activity involved in apoptotic processGNB2L1;BAD;NLRP12;CASP1;CTSC;CTSH;MAPK9;BCL2L13;NLRP1
cysteine-type endopeptidase activityUSP13;CASP6L2;USP37;USP9X;USP15;MALT1A;UCHL1;USP4;CTSL2
cysteine-type peptidase activityCAPN1B;CASP6L1;CTSLL;SENP7;CASPC;CAPN3A;USP43;OTUD7B;CAPN2A
identical protein bindingRAD52;SMURF2;MTSS1;HSD17B10;GOT1L1;ACTB;MAP3K11;SMAD3;FHL2
phosphatase bindingSPRED1;KIAA0649;CNST;DZIP3;DLG3;PPP1R18;SH3YL1;SMAD2;SLC9A3R2
protein bindingGYG1;CRYAB;ORMDL3;SYNGR1;SGOL2;COBRA1;GEMIN6;KAZN;MRPL13
protein self-associationPABPN1;LDB1;S100A7A;AGA;MALT1;TP53;TRIM32;ZSWIM2;PCSK9
serine-type endopeptidase activityIMMP1L;CTSG;Acr;LPA;PRSS21;LOC780933;TPSAB1;KLK1B1;PRSS59.1

Ctsc has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctsc here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctsc.

CST7; q1hvd6_ebva8; q7cgu7_yerpe; pepS; tal1; nrdB; nemA; gcvP; Bub1; Ktn1; Nek2; FGFR1OP; Tuba3a; MAPK8; Smo; G3BP1; SGOL1; Ppp2r1a

Wang, XW; Liu, Y; et al. Long-term change of disease behavior in Papillon-Lefevre syndrome: Seven years follow-up. EUROPEAN JOURNAL OF MEDICAL GENETICS 58:184-187(2015).
Gregersen, VR; Gustavsson, F; et al. Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. JOURNAL OF DAIRY SCIENCE 98:1261-1272(2015).
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