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CTSF

  • Official Full Name

    cathepsin F

  • Overview

    Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.
  • Synonyms

    CTSF; cathepsin F; CATSF; AI481912; CathepsinF; EC 3.4.22.41;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • Free Style 293-F Cell
  • HEK293
  • In Vitro Cell Free System
  • Insect cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTSF-2105H Recombinant Human CTSF Protein, GST-tagged Wheat Germ GST
Human CTSF-15903H Recombinant Human CTSF, His-tagged E.coli His 271-484aa
Human CTSF-506H Recombinant Human Cathepsin F, His-tagged Free Style 293-F Cell His
Human CTSF-420HCL Recombinant Human CTSF cell lysate N/A
Human CTSF-2347HF Recombinant Full Length Human CTSF Protein, GST-tagged In Vitro Cell Free System GST 484 amino acids
Human CTSF-2857H Recombinant Human CTSF protein, His-tagged E.coli His 136 - 484 aa
Human CTSF-05H Active Recombinant Human CTSF Protein, His-tagged Insect cell His 20-484aa
Human CTSF-5295H Recombinant Human CTSF protein, His-tagged E.coli His 273-484aa
Mouse CTSF-4051M Recombinant Mouse CTSF Protein Mammalian Cell His
Mouse Ctsf-8182M Recombinant Mouse Ctsf protein, His & T7-tagged E.coli His/T7 Ala249~Asn462 (Accession # Q9R013)
Mouse CTSF-2066M-B Recombinant Mouse CTSF Protein Pre-coupled Magnetic Beads HEK293
Mouse CTSF-2066M Recombinant Mouse CTSF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CTSF-4778Z Recombinant Zebrafish CTSF Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CTSF Related Articles

CTSF involved in several pathways and played different roles in them. We selected most pathways CTSF participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LysosomeATP6V0A2;HEXB;AP4M1;ARSA;GLA;IDUA;ACP5A;NAGLU;CTSZ

CTSF has several biochemical functions, for example, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSF itself. We selected most functions CTSF had, and list some proteins which have the same functions with CTSF. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase activityCASP8;CTSLL;USP3;CTS7;BLMH;DUB1;CTSL2;CASP3A;ATG4D

CTSF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSF.

Ahn, CS; Na, BK; et al. Expression characteristics and specific antibody reactivity of diverse cathepsin F members of Paragonimus westermani. PARASITOLOGY INTERNATIONAL 64:37-42(2015).
Wongwairot, S; Kueakhai, P; et al. Monoclonal antibody against recombinant Fasciola gigantica cathepsin L1H could detect juvenile and adult cathepsin Ls of Fasciola gigantica. PARASITOLOGY RESEARCH 114:133-140(2015).
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