CTSL1
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Official Full Name
cathepsin L1
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Overview
Cathepsin L is a lysosomal endopeptidase belonging to the papain cysteine protease superfamily. Macrophages and osteoclasts secrete the precursor of cathepsin L, procathepsin L, which is processed to some form of active enzyme by acid, surface activation, or proteolysis. It is then involved in connective tissue degradation and the turnover of extracellular matrix proteins. Procathepsin L is also secreted by many malignantly transformed cells, mRNA, and its protein expression levels, as well as the extent to which it is secreted are correlated to the malignant potential of these cells. As cathepsin L is capable of degrading protein constituents of the extracellular matrix, it may play a crucial role in tumor progression, metastasis, and other disorders involving the destruction of the extracellular matrix. Inhibition of the enzyme or the proenzyme by low molecular weight inhibitors or antibodies and in vivo lead to a suppression of the invasiveness of malignant cells or a decline in their ability to form tumors. -
Synonyms
RP11-65B23.1; CATL; CTSL; MEP; cathepsin L; major excreted protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Chlorocebus Aethiops
- Human
- Rat
- E.coli
- HEK293
- Human Cell
- Human Liver
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | CTSL1-91H | Recombinant Human cathepsin L1 | E.coli | N/A | ||
Human | CTSL1-26491TH | Recombinant Human CTSL1, His-tagged | E.coli | His | ||
Human | CTSL1-11690H | Recombinant Human CTSL1, GST-tagged | E.coli | GST | 1-333a.a. | |
Human | CTSL1-896H | Recombinant Human CTSL1 protein, His-tagged | HEK293 | His | Thr18-Val333 | |
Human | CTSL1-3022HCL | Recombinant Human CTSL1 cell lysate | Human Cell | N/A | ||
Human | CTSL1-1859H | Native Human Cathepsin L1 | Human Liver | N/A | ||
Human | CTSL1-27406TH | Native Human CTSL1 | N/A | |||
Rat | CTSL1-1668R | Recombinant Rat CTSL1 Protein | Mammalian Cell | His | ||
Rat | CTSL1-1327R-B | Recombinant Rat CTSL1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | CTSL1-1327R | Recombinant Rat CTSL1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Chlorocebus Aethiops | CTSL1-441C | Recombinant Chlorocebus Aethiops CTSG Protein (114-333 aa), His-SUMO-tagged | E.coli | His/SUMO | 114-333 aa |
- Involved Pathway
- Protein Function
- Interacting Protein
- CTSL1 Related Articles
CTSL1 involved in several pathways and played different roles in them. We selected most pathways CTSL1 participated on our site, such as Adaptive Immune System, Antigen processing and presentation, Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | CREB1B;DNM1;THEM4;SEC61B;SPSB4;RNF111;CD300E;UBA5;GRAP2B |
Antigen processing and presentation | CD74;KIR2DL3;KLRC1;HSPA1L;KIR2DL1;KIR2DS4;HLA-DPA1;NFYA;HSPA8 |
Antigen processing-Cross presentation | CTSL1;CYBB;CTSL2;CYBA;SEC61B;FCGR1B;CTSS;CD207 |
Assembly of collagen fibrils and other multimeric structures | TLL2;CTSL2;MMP13;COL4A6;COL6A1;COL8A2;COL8A1A;CTSS;COL1A2 |
Class I MHC mediated antigen processing & | ASB8;RNF6;FBXO44;ERAP2;SEC23A;RNF4;TRIM9;RNF14;TRIM69 |
presentation | GAN;STUB1;ASB10;ASB11;LRR1;ASB9;DTX3L;HECTD3;TRIM41 |
Collagen degradation | CTSB;MMP13;ADAM9;COL15A1B;CTSK;COL19A1;LOC100686744;MMP8;ELANE |
Collagen formation | COL10A1;LOXL4;COL3A1;COL28A1A;DST;ADAMTS3;COL6A1;LOXL2;COL6A2 |
Degradation of the extracellular matrix | COL9A3;MMP24;ELANE;CTSLL;BMP1B;MMP13;CTSG;ADAMTS5;NID1 |
CTSL1 has several biochemical functions, for example, collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSL1 itself. We selected most functions CTSL1 had, and list some proteins which have the same functions with CTSL1. You can find most of the proteins on our site.
Function | Related Protein |
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collagen binding | MRC2;MTAP1A;LACRT;CCBE1;RELL2;CTSB;HSD17B12;DCN;SERPINH1B |
cysteine-type endopeptidase activity | FAM49BA;CTSF;MALT1A;USP43A;CASPB;USP6;CTSB;USP49;USP8 |
cysteine-type peptidase activity | CTLA2B;CTSSB.1;CTSLL;ALG13;CTSJ;CTSL2;SENP8;CAPN1A;SENP3B |
fibronectin binding | MFAP2;CTGF;CTSL1;ITGB1;HSD17B12;SFRP2;FSTL3;LPA;THBS1 |
histone binding | CTSL2;HIST1H3I;ELP2;NAP1L2;SET;RNF168;RAG1;ASF1A;CTCFL |
protein binding | C19orf47;TAF2;CA4;INPP4B;SULT1E1;EWSR1A;GBP1;ZNF350;DOK1 |
proteoglycan binding | SLIT2;CTSL1;CTSK;CTSS;CECR1;THBS1;CECR1A;NID1;UBE4A |
serpin family protein binding |
CTSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSL1.
SGTA; srp-6; BTN3A3; EED; PPP1CC; GEM; RELB; CRELD2; alsS; IGHA1; APOA1; ALB; TF; cona_canen
- Q&As
- Reviews
Q&As (6)
Ask a questionThe activity of CTSL1 protein is mainly affected by some internal and external environmental factors, such as pH value, calcium ion concentration, protein folding state, substrate concentration, etc. In addition, some gene knockouts or mutations may also affect its activity.
CTSL1 protein plays a role in many diseases, such as cancer, autoimmune diseases, neurodegenerative diseases, etc. It may be involved in the pathogenesis of diseases and may become a new target for the treatment of these diseases.
Through gene knockout or overexpression technology, the effect of CTSL1 protein on cell growth, apoptosis, migration and other biological behaviors was observed, and changes in related signaling pathways were detected to verify the role of CTSL1 protein in diseases.
The expression level of CTSL1 protein is mainly affected by transcription and post-transcriptional modifications. Some gene knockouts or mutations may affect their expression levels, while some drugs or other small molecule compounds may also affect their expression levels by regulating transcription or post-transcriptional modifications.
Interaction between the CTSL1 protein and other proteins is complex, and they may form complexes or interact with other enzymes to achieve the breakdown of macromolecular substances or participate in signaling.
CTSL1 protein plays a role in promoting apoptosis. It can promote programmed death of cells by activating apoptosis-associated proteases such as CASP3.
Customer Reviews (3)
Write a reviewThis repeatability of CTSL1 has reached an unprecedented level, so that researchers can safely reuse it, greatly improving the efficiency of research.
The catalytic activity of CTSL1 is very excellent, which can greatly improve the efficiency and rate of chemical reactions, and provide a new way for industrial production.
The production process of CTSL1 is very environmentally friendly, reducing the generation of pollution from the source, making large-scale production possible and without negative impact on the environment.
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