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CTSL1

  • Official Full Name

    cathepsin L1

  • Overview

    Cathepsin L is a lysosomal endopeptidase belonging to the papain cysteine protease superfamily. Macrophages and osteoclasts secrete the precursor of cathepsin L, procathepsin L, which is processed to some form of active enzyme by acid, surface activation, or proteolysis. It is then involved in connective tissue degradation and the turnover of extracellular matrix proteins. Procathepsin L is also secreted by many malignantly transformed cells, mRNA, and its protein expression levels, as well as the extent to which it is secreted are correlated to the malignant potential of these cells. As cathepsin L is capable of degrading protein constituents of the extracellular matrix, it may play a crucial role in tumor progression, metastasis, and other disorders involving the destruction of the extracellular matrix. Inhibition of the enzyme or the proenzyme by low molecular weight inhibitors or antibodies and in vivo lead to a suppression of the invasiveness of malignant cells or a decline in their ability to form tumors.
  • Synonyms

    RP11-65B23.1; CATL; CTSL; MEP; cathepsin L; major excreted protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chlorocebus Aethiops
  • Human
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Human Liver
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTSL1-91H Recombinant Human cathepsin L1 E.coli N/A
Human CTSL1-26491TH Recombinant Human CTSL1, His-tagged E.coli His
Human CTSL1-11690H Recombinant Human CTSL1, GST-tagged E.coli GST 1-333a.a.
Human CTSL1-896H Recombinant Human CTSL1 protein, His-tagged HEK293 His Thr18-Val333
Human CTSL1-3022HCL Recombinant Human CTSL1 cell lysate Human Cell N/A
Human CTSL1-1859H Native Human Cathepsin L1 Human Liver N/A
Human CTSL1-27406TH Native Human CTSL1 N/A
Rat CTSL1-1668R Recombinant Rat CTSL1 Protein Mammalian Cell His
Rat CTSL1-1327R-B Recombinant Rat CTSL1 Protein Pre-coupled Magnetic Beads HEK293
Rat CTSL1-1327R Recombinant Rat CTSL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chlorocebus Aethiops CTSL1-441C Recombinant Chlorocebus Aethiops CTSG Protein (114-333 aa), His-SUMO-tagged E.coli His/SUMO 114-333 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CTSL1 Related Articles

CTSL1 involved in several pathways and played different roles in them. We selected most pathways CTSL1 participated on our site, such as Adaptive Immune System, Antigen processing and presentation, Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemCREB1B;DNM1;THEM4;SEC61B;SPSB4;RNF111;CD300E;UBA5;GRAP2B
Antigen processing and presentationCD74;KIR2DL3;KLRC1;HSPA1L;KIR2DL1;KIR2DS4;HLA-DPA1;NFYA;HSPA8
Antigen processing-Cross presentationCTSL1;CYBB;CTSL2;CYBA;SEC61B;FCGR1B;CTSS;CD207
Assembly of collagen fibrils and other multimeric structuresTLL2;CTSL2;MMP13;COL4A6;COL6A1;COL8A2;COL8A1A;CTSS;COL1A2
Class I MHC mediated antigen processing &ampASB8;RNF6;FBXO44;ERAP2;SEC23A;RNF4;TRIM9;RNF14;TRIM69
presentationGAN;STUB1;ASB10;ASB11;LRR1;ASB9;DTX3L;HECTD3;TRIM41
Collagen degradationCTSB;MMP13;ADAM9;COL15A1B;CTSK;COL19A1;LOC100686744;MMP8;ELANE
Collagen formationCOL10A1;LOXL4;COL3A1;COL28A1A;DST;ADAMTS3;COL6A1;LOXL2;COL6A2
Degradation of the extracellular matrixCOL9A3;MMP24;ELANE;CTSLL;BMP1B;MMP13;CTSG;ADAMTS5;NID1

CTSL1 has several biochemical functions, for example, collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSL1 itself. We selected most functions CTSL1 had, and list some proteins which have the same functions with CTSL1. You can find most of the proteins on our site.

Function Related Protein
collagen bindingMRC2;MTAP1A;LACRT;CCBE1;RELL2;CTSB;HSD17B12;DCN;SERPINH1B
cysteine-type endopeptidase activityFAM49BA;CTSF;MALT1A;USP43A;CASPB;USP6;CTSB;USP49;USP8
cysteine-type peptidase activityCTLA2B;CTSSB.1;CTSLL;ALG13;CTSJ;CTSL2;SENP8;CAPN1A;SENP3B
fibronectin bindingMFAP2;CTGF;CTSL1;ITGB1;HSD17B12;SFRP2;FSTL3;LPA;THBS1
histone bindingCTSL2;HIST1H3I;ELP2;NAP1L2;SET;RNF168;RAG1;ASF1A;CTCFL
protein bindingC19orf47;TAF2;CA4;INPP4B;SULT1E1;EWSR1A;GBP1;ZNF350;DOK1
proteoglycan bindingSLIT2;CTSL1;CTSK;CTSS;CECR1;THBS1;CECR1A;NID1;UBE4A
serpin family protein binding

CTSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSL1.

SGTA; srp-6; BTN3A3; EED; PPP1CC; GEM; RELB; CRELD2; alsS; IGHA1; APOA1; ALB; TF; cona_canen

Mas-Coma, S; Bargues, MD; et al. Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario. PARASITOLOGY 141:1918-1946(2014).
Toet, H; Piedrafita, DM; et al. Liver fluke vaccines in ruminants: strategies, progress and future opportunities. INTERNATIONAL JOURNAL FOR PARASITOLOGY 44:915-927(2014).
  • Q&As
  • Reviews

Q&As (6)

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How is the activity of CTSL1 protein regulated? 08/14/2022

The activity of CTSL1 protein is mainly affected by some internal and external environmental factors, such as pH value, calcium ion concentration, protein folding state, substrate concentration, etc. In addition, some gene knockouts or mutations may also affect its activity.

In which diseases does the CTSL1 protein play? 05/02/2022

CTSL1 protein plays a role in many diseases, such as cancer, autoimmune diseases, neurodegenerative diseases, etc. It may be involved in the pathogenesis of diseases and may become a new target for the treatment of these diseases.

How to verify the role of CTSL1 protein in disease experimentally? 08/18/2021

Through gene knockout or overexpression technology, the effect of CTSL1 protein on cell growth, apoptosis, migration and other biological behaviors was observed, and changes in related signaling pathways were detected to verify the role of CTSL1 protein in diseases.

How is the expression level of CTSL1 protein regulated? 04/06/2021

The expression level of CTSL1 protein is mainly affected by transcription and post-transcriptional modifications. Some gene knockouts or mutations may affect their expression levels, while some drugs or other small molecule compounds may also affect their expression levels by regulating transcription or post-transcriptional modifications.

What is the interaction between the CTSL1 protein and other proteins? 06/26/2020

Interaction between the CTSL1 protein and other proteins is complex, and they may form complexes or interact with other enzymes to achieve the breakdown of macromolecular substances or participate in signaling.

What is the role of the CTSL1 protein in apoptosis? 04/25/2019

CTSL1 protein plays a role in promoting apoptosis. It can promote programmed death of cells by activating apoptosis-associated proteases such as CASP3.

Customer Reviews (3)

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Reviews
04/23/2022

    This repeatability of CTSL1 has reached an unprecedented level, so that researchers can safely reuse it, greatly improving the efficiency of research.

    08/18/2021

      The catalytic activity of CTSL1 is very excellent, which can greatly improve the efficiency and rate of chemical reactions, and provide a new way for industrial production.

      06/13/2021

        The production process of CTSL1 is very environmentally friendly, reducing the generation of pollution from the source, making large-scale production possible and without negative impact on the environment.

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