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CTSS

  • Official Full Name

    cathepsin S

  • Overview

    The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
  • Synonyms

    CTSS; cathepsin S;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Human Spleen
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTSS-750H Recombinant Human Cathepsin S E.coli N/A
Human CTSS-282H Active Recombinant Human CTSS protein(Met1-Ile331), His-tagged HEK293 C-His Met1-Ile331
Human CTSS-1651H Recombinant Human Cathepsin S Human Spleen N/A
Human CTSS-7251H Recombinant Human CTSS, His-tagged E.coli His 17-331aa
Human CTSS-283H Recombinant Human CTSS Protein, His-tagged HEK293 His Gln 17 - Ile 331 (pro) & Ser 109 - Ile 331 (mature)
Human CTSS-2118H Recombinant Human CTSS Protein, GST-tagged Wheat Germ GST
Human CTSS-3021HCL Recombinant Human CTSS cell lysate Human Cell N/A
Human CTSS-2695H Active Recombinant Human CTSS protein, His-tagged HEK293 His Gln17-Ile331
Human CTSS-27405TH Native Human CTSS N/A
Human CTSS-2766H Recombinant Human CTSS protein, His-tagged E.coli His 115-331aa
Human CTSS-1590H Recombinant Human CTSS Protein (Gln17-Ile331), C-His tagged Mammalian cells C-His Gln17-Ile331
Human CTSS-1893H Recombinant Human CTSS Protein (Leu115-Ile331), His tagged E.coli His Leu115-Ile331
Human CTSS-2363HF Recombinant Full Length Human CTSS Protein, GST-tagged In Vitro Cell Free System GST 331 amino acids
Human CTSS-01H Active Recombinant Human CTSS Protein, Fc-Tagged NS0 Fc
Mouse CTSS-911M Active Recombinant Mouse CTSS Protein, His-tagged HEK293 His
Mouse Ctss-69M Recombinant Mouse Ctss Protein, His-tagged Insect Cell His
Mouse Ctss-1985M Recombinant Mouse Ctss protein, His-tagged E.coli His Leu123~Glu339
Mouse CTSS-1563MCL Recombinant Mouse CTSS cell lysate Human Cell N/A
Mouse Ctss-7189M Recombinant Mouse Ctss Protein, His-tagged His 21-340 (325aa)
Mouse ctss-2767M Recombinant Mouse ctss protein, His-tagged E.coli His 123-340aa
Rat CTSS-1670R Recombinant Rat CTSS Protein Mammalian Cell His
Rat Ctss-1113R Recombinant Rat Ctss Protein, His-tagged HEK293 His
Rat CTSS-1329R-B Recombinant Rat CTSS Protein Pre-coupled Magnetic Beads HEK293
Rat Ctss-1293R Recombinant Rat Ctss Protein, His-tagged E.coli N-His Leu113-Ile330
Rat CTSS-1329R Recombinant Rat CTSS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle CTSS-1984C Recombinant Cattle CTSS protein, His & T7-tagged E.coli His/T7 Leu115~Ile331 (Accession # P25326)
Chicken CTSS-2999C Recombinant Chicken CTSS Mammalian Cell His
Kit-2353 Cathepsin S Inhibitor Screening Kit (Fluorometric) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CTSS Related Articles
  • CTSS Related Research Area

CTSS involved in several pathways and played different roles in them. We selected most pathways CTSS participated on our site, such as Adaptive Immune System, Antigen processing and presentation, Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemCTSL2;KIF22;TRIM41;GAN;MAPKAP1;CTS7;SPSB4;CD96;IGHM
Antigen processing and presentationKIR2DS2;KLRC2;KIR2DS4;B2M;TAP1;HLA-DPA1;KLRC3;CTSL1;CD8A
Antigen processing-Cross presentationCTSL1;CTSL2;CYBB;CD207;CYBA;FCGR1B;SEC61B;CTSS
Assembly of collagen fibrils and other multimeric structuresCOL5A3B;COL11A1B;CD151;COL6A3;LOXL2;COL4A4;MMP20;PCOLCE;COL8A1A
Class I MHC mediated antigen processing &ampASB10;DZIP3;SEC61B;TRIM63;FCGR1B;LRR1;ATG7;RNF111;GAN
presentationRNF144B;CTSS;SPSB2;RNF19B;TRIM69;UBE2V2;SEC24A;UBA5;ASB4
Collagen formationTLL2;BMP1B;COL6A1;COL5A3A;SERPINH1;COL5A1;LOXL1;COL11A1B;COL10A1A
Degradation of the extracellular matrixCAPNS1;MMP10;ADAMTS18;MMP20;TPSAB1;COL25A1;NID1;COL19A1;ELANE
Endosomal/Vacuolar pathway

CTSS has several biochemical functions, for example, collagen binding, cysteine-type endopeptidase activity, fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSS itself. We selected most functions CTSS had, and list some proteins which have the same functions with CTSS. You can find most of the proteins on our site.

Function Related Protein
collagen bindingNID2;PDGFA;COMP;DCN;TLL1;C1QTNF1;MMP9;SMAD3;ABI3BP
cysteine-type endopeptidase activityUSP47;CASP14;CTSL.1;USP50;CFLARA;USP20;CTSLL;USP28;USP18
fibronectin bindingCTSS;MFAP2;SFRP2;FSTL3;MMP13;CCDC80;ITGB1;CTGF;VEGFA
laminin bindingGPC1;TINAGL1;THBS1;PLEKHA2;NID1;LGALS1;LGALS3;RPSA;ITGA7
proteoglycan bindingCTSB;SLIT2;NID1;CTSL1;CTSK;CTSS;CECR1A;CECR1;UBE4A

CTSS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSS here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSS.

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Hamm-Alvarez, SF; Janga, SR; et al. Tear Cathepsin S as a Candidate Biomarker for Sjogren's Syndrome. ARTHRITIS & RHEUMATOLOGY 66:1872-1881(2014).
Barderas, R; Mendes, M; et al. In-depth Characterization of the Secretome of Colorectal Cancer Metastatic Cells Identifies Key Proteins in Cell Adhesion, Migration, and Invasion. MOLECULAR & CELLULAR PROTEOMICS 12:1602-1620(2013).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How can the function of CTSS proteins be studied by gene knockout or knockdown techniques? 04/17/2022

The function of CTSS proteins can be studied through gene knockout or knockdown techniques, such as using techniques such as CRISPR-Cas9 or RNAi. These techniques can create cellular models of missing or reduced CTSS proteins to observe their effects on cell death, among other things.

How can I detect the expression level of CTSS protein? 02/05/2022

Expression level of CTSS protein can be detected by immunohistochemistry, western blotting, and real-time quantitative PCR.

How is CTSS protein involved in the process of apoptosis? 10/06/2021

CTSS proteins promote cell death by degrading proteins inside cells. During apoptosis, CTSS proteins degrade key proteins within cells, leading to cell death.

Are the interactions between CTSS proteins and other proteins regulated? 05/04/2021

The interaction between CTSS proteins and other proteins is regulated by the formation of complexes or the regulation of signal transduction pathways. These interactions can be influenced by a variety of factors, such as ion concentrations, neurotransmitters, and growth factors.

What is the relationship between the expression level of CTSS protein and the occurrence and progression of diseases? 02/08/2021

Some studies have shown that the expression level of CTSS protein may be associated with the onset and progression of certain diseases. For example, in some cancers, the expression level of the CTSS protein may change.

In which organelles is CTSS protein expressed? 09/18/2020

It is mainly expressed in lysosomes, which is one of the major proteases in lysosomes.

Customer Reviews (3)

Write a review
Reviews
11/01/2021

    High catalytic efficiency, short time, saving time.

    06/13/2021

      The solubility is very good and can be easily dissolved in various buffers.

      03/27/2021

        Anti-pollution ability is very strong, not easy to be polluted.

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