CTSS
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Official Full Name
cathepsin S
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Overview
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010] -
Synonyms
CTSS; cathepsin S;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cattle
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human Cell
- Human Spleen
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- NS0
- Wheat Germ
- C
- His
- Fc
- GST
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CTSS Related Articles
- CTSS Related Research Area
CTSS involved in several pathways and played different roles in them. We selected most pathways CTSS participated on our site, such as Adaptive Immune System, Antigen processing and presentation, Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | CTSL2;KIF22;TRIM41;GAN;MAPKAP1;CTS7;SPSB4;CD96;IGHM |
Antigen processing and presentation | KIR2DS2;KLRC2;KIR2DS4;B2M;TAP1;HLA-DPA1;KLRC3;CTSL1;CD8A |
Antigen processing-Cross presentation | CTSL1;CTSL2;CYBB;CD207;CYBA;FCGR1B;SEC61B;CTSS |
Assembly of collagen fibrils and other multimeric structures | COL5A3B;COL11A1B;CD151;COL6A3;LOXL2;COL4A4;MMP20;PCOLCE;COL8A1A |
Class I MHC mediated antigen processing & | ASB10;DZIP3;SEC61B;TRIM63;FCGR1B;LRR1;ATG7;RNF111;GAN |
presentation | RNF144B;CTSS;SPSB2;RNF19B;TRIM69;UBE2V2;SEC24A;UBA5;ASB4 |
Collagen formation | TLL2;BMP1B;COL6A1;COL5A3A;SERPINH1;COL5A1;LOXL1;COL11A1B;COL10A1A |
Degradation of the extracellular matrix | CAPNS1;MMP10;ADAMTS18;MMP20;TPSAB1;COL25A1;NID1;COL19A1;ELANE |
Endosomal/Vacuolar pathway |
CTSS has several biochemical functions, for example, collagen binding, cysteine-type endopeptidase activity, fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSS itself. We selected most functions CTSS had, and list some proteins which have the same functions with CTSS. You can find most of the proteins on our site.
Function | Related Protein |
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collagen binding | NID2;PDGFA;COMP;DCN;TLL1;C1QTNF1;MMP9;SMAD3;ABI3BP |
cysteine-type endopeptidase activity | USP47;CASP14;CTSL.1;USP50;CFLARA;USP20;CTSLL;USP28;USP18 |
fibronectin binding | CTSS;MFAP2;SFRP2;FSTL3;MMP13;CCDC80;ITGB1;CTGF;VEGFA |
laminin binding | GPC1;TINAGL1;THBS1;PLEKHA2;NID1;LGALS1;LGALS3;RPSA;ITGA7 |
proteoglycan binding | CTSB;SLIT2;NID1;CTSL1;CTSK;CTSS;CECR1A;CECR1;UBE4A |
CTSS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSS here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSS.
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- Q&As
- Reviews
Q&As (6)
Ask a questionThe function of CTSS proteins can be studied through gene knockout or knockdown techniques, such as using techniques such as CRISPR-Cas9 or RNAi. These techniques can create cellular models of missing or reduced CTSS proteins to observe their effects on cell death, among other things.
Expression level of CTSS protein can be detected by immunohistochemistry, western blotting, and real-time quantitative PCR.
CTSS proteins promote cell death by degrading proteins inside cells. During apoptosis, CTSS proteins degrade key proteins within cells, leading to cell death.
The interaction between CTSS proteins and other proteins is regulated by the formation of complexes or the regulation of signal transduction pathways. These interactions can be influenced by a variety of factors, such as ion concentrations, neurotransmitters, and growth factors.
Some studies have shown that the expression level of CTSS protein may be associated with the onset and progression of certain diseases. For example, in some cancers, the expression level of the CTSS protein may change.
It is mainly expressed in lysosomes, which is one of the major proteases in lysosomes.
Customer Reviews (3)
Write a reviewHigh catalytic efficiency, short time, saving time.
The solubility is very good and can be easily dissolved in various buffers.
Anti-pollution ability is very strong, not easy to be polluted.
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