cttn
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  • Official Full Name
  • cortactin
  • Background
  • This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
  • Synonyms
  • CTTN; cortactin; EMS1, ems1 sequence (mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); src substrate cortactin; amplaxin; 1110020L01Rik; oncogene EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/8
Cat.#:Cttn-431MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cttn Protein, His-tagged
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Cat.#:Cttn-432RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cttn Protein, His-tagged
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Cat.#:CTTN-27962THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTTN, His-tagged
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Cat.#:CTTN-27HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CTTN, GST-tagged
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Cat.#:CTTN-28HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTTN, MYC/DDK-tagged
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Cat.#:CTTN-782HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human CTTN Protein, DDK-tagged
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Cat.#:CTTN-1671RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CTTN Protein
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Cat.#:CTTN-1090RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CTTN Protein, His-tagged
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Cat.#:CTTN-7017CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CTTN
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Cat.#:CTTN-1230ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CTTN
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Cat.#:CTTN-421HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CTTN cell lysate
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Involved Pathway

CTTN involved in several pathways and played different roles in them. We selected most pathways CTTN participated on our site, such as Tight junction, Bacterial invasion of epithelial cells, Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Tight junction
SHROOM3; CLDN3; ACTG1; CLDN7; TJAP1; MYHZ2; PRKCBB; EPB41L1; ACTN4; PARD6A
Bacterial invasion of epithelial cells
ELMO1; PIK3R1; CTNNA1; PIK3CG; CLTB; ILK; ARPC3; WASL; CD2AP; PIK3R3
Pathogenic Escherichia coli infection
EZR; TUBA8; ROCK2; HCLS1; TUBA1C; TLR4; CTTN; TLR5; PRKCA; TUBA3C
Shigellosis
MAD2L2; WAS; IKBKG; IKBKB; IL-8; U2AF1; MAPK1; ATG5; NFKBIA; MAPK3
Proteoglycans in cancer
CBLB; PPP1CB; MTOR; TLR2; HRAS; FAS; CAMK2G; MET; ANK1; SOS1

Protein Function

CTTN has several biochemical functions, for example, profilin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTTN itself. We selected most functions CTTN had, and list some proteins which have the same functions with CTTN. You can find most of the proteins on our site.
Function
Related Protein
Function profilin binding
Related Protein EVL; VASP; DIAP1; RHOQ; HTT; WIPF1; CTTN; PCLO; DIAPH1; CYFIP1
Function protein binding
Related Protein POLH; VPS36; TRIM69; NLRP12; GNB1B; TMEM183A; PKN1; VMP1; C9orf86; NPY2R

Interacting Protein

CTTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTTN here. Most of them are supplied by our site. Hope this information will be useful for your research of CTTN.
ASAP1; DNM2; GRB2; Kcnma1; ARRB2