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CYBA

  • Official Full Name

    cytochrome b-245, alpha polypeptide

  • Overview

    Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]
  • Synonyms

    CYBA; cytochrome b-245, alpha polypeptide; p22-PHOX; cytochrome b-245 light chain; p22phox; cytochrome b light chain; p22 phagocyte B-cytochrome; cytochrome b(558) alpha chain; cytochrome b558 subunit alpha; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; flavocytochrome b-558 alpha polypeptide; neutrophil cytochrome b 22 kDa polypeptide; superoxide-generating NADPH oxidase light chain subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Dictyostelium discoideum (Slime mold)
  • Human
  • Rat
  • Zebrafish
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYBA-2221H Recombinant Human CYBA Protein, GST-tagged Wheat Germ GST
Human CYBA-7139HCL Recombinant Human CYBA 293 Cell Lysate HEK293 N/A
Human CYBA-2386HF Recombinant Full Length Human CYBA Protein, GST-tagged In Vitro Cell Free System GST 254 amino acids
Rat CYBA-1706R Recombinant Rat CYBA Protein Mammalian Cell His
Rat CYBA-1365R-B Recombinant Rat CYBA Protein Pre-coupled Magnetic Beads HEK293
Rat CYBA-1365R Recombinant Rat CYBA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Dictyostelium discoideum (Slime mold) RFL34531DF Recombinant Full Length Dictyostelium Discoideum Superoxide-Generating Nadph Oxidase Light Chain Subunit(Cyba) Protein, His-Tagged E.coli expression system His Full Length (1-118)
Zebrafish CYBA-10857Z Recombinant Zebrafish CYBA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CYBA involved in several pathways and played different roles in them. We selected most pathways CYBA participated on our site, such as Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYBA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemCLEC2H;ATG7;KLRB1A;AGO1;LILRA2;ASB13;LRRC41;SIGLEC9;ASB2
Antigen processing-Cross presentationCTSL2;CTSS;FCGR1B;CTSL1;SEC61B;CD207;CYBB;CYBA
Class I MHC mediated antigen processing &ampKLHL21;KLHL20;DTX3L;UFL1;UBE2U;SPSB1;ERAP1;FBXO27;RNF111
presentationGAN;FBXO3;ASB14;SEC23A;RNF144B;PJA1;TRIM11;RNF25;SEC61B
Cross-presentation of particulate exogenous antigens (phagosomes)CYBB;CYBA
Immune SystemGBP5;RAPGEF3;IFIT2;USP18;SOCS3A;CRP;HERC5;TRIM62;ACTR2B
LeishmaniasisHLA-DRB4;HLA-DQB1;NFKBIA;PTPN6;TGFB1;NCF4;FCGR2A;PRKCB;FOS
Leukocyte transendothelial migrationMMP9;ITGB2L;TXK;CLDN20;MYLPF;PRKCA;ROCK1;RAC2;CLDN23
Osteoclast differentiationLILRB4;CSF1R;CYBB;TGFB1;SIRPB1;RELB;NFKB2;CSF1;CYLD

CYBA has several biochemical functions, for example, SH3 domain binding, electron carrier activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYBA itself. We selected most functions CYBA had, and list some proteins which have the same functions with CYBA. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingLANCL1;SH3BGRL;CNTNAP1;QKI2;ADAM12;FMN1;GJA1;QKI;ITGB1BP2
electron carrier activityHSD17B6;TXNRD1;ETFDH;ALDH4A1;SDHB;CYBA;PRKRA;ALDH2;GCDHA
heme bindingSDHD;CYGB;CYP2F1;CYP4F3;HBB-BH1;HBBE1.1;CYP2W1;CYGB2;GUCY1B3
metal ion bindingLNX2;RORAB;ZBBX;ZBTB16;MEP1A.1;ZNRF3;TENC1;FCER2;ZC3H13
protein bindingZFYVE9;TAX1BP3;ASMTL;DULLARD;SLC52A2;HYI;PAM;CD8B1;CTNNAL1
protein heterodimerization activityTWIST1;NFYC;H2AFY;DVL3;CUL3;PDGFB;DRD2;TLR6;TGFB3
contributes_to superoxide-generating NADPH oxidase activityCYBA;CYBB

CYBA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYBA here. Most of them are supplied by our site. Hope this information will be useful for your research of CYBA.

NCF1; NOXO1; MDFI; NCF4; CPT1A; RCHY1; MYC

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