CYBA
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Official Full Name
cytochrome b-245, alpha polypeptide
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Overview
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008] -
Synonyms
CYBA; cytochrome b-245, alpha polypeptide; p22-PHOX; cytochrome b-245 light chain; p22phox; cytochrome b light chain; p22 phagocyte B-cytochrome; cytochrome b(558) alpha chain; cytochrome b558 subunit alpha; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; flavocytochrome b-558 alpha polypeptide; neutrophil cytochrome b 22 kDa polypeptide; superoxide-generating NADPH oxidase light chain subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Dictyostelium discoideum (Slime mold)
- Human
- Rat
- Zebrafish
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | CYBA-2221H | Recombinant Human CYBA Protein, GST-tagged | Wheat Germ | GST | ||
Human | CYBA-7139HCL | Recombinant Human CYBA 293 Cell Lysate | HEK293 | N/A | ||
Human | CYBA-2386HF | Recombinant Full Length Human CYBA Protein, GST-tagged | In Vitro Cell Free System | GST | 254 amino acids | |
Rat | CYBA-1706R | Recombinant Rat CYBA Protein | Mammalian Cell | His | ||
Rat | CYBA-1365R-B | Recombinant Rat CYBA Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | CYBA-1365R | Recombinant Rat CYBA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Dictyostelium discoideum (Slime mold) | RFL34531DF | Recombinant Full Length Dictyostelium Discoideum Superoxide-Generating Nadph Oxidase Light Chain Subunit(Cyba) Protein, His-Tagged | E.coli expression system | His | Full Length (1-118) | |
Zebrafish | CYBA-10857Z | Recombinant Zebrafish CYBA | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
CYBA involved in several pathways and played different roles in them. We selected most pathways CYBA participated on our site, such as Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing &, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYBA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | CLEC2H;ATG7;KLRB1A;AGO1;LILRA2;ASB13;LRRC41;SIGLEC9;ASB2 |
Antigen processing-Cross presentation | CTSL2;CTSS;FCGR1B;CTSL1;SEC61B;CD207;CYBB;CYBA |
Class I MHC mediated antigen processing & | KLHL21;KLHL20;DTX3L;UFL1;UBE2U;SPSB1;ERAP1;FBXO27;RNF111 |
presentation | GAN;FBXO3;ASB14;SEC23A;RNF144B;PJA1;TRIM11;RNF25;SEC61B |
Cross-presentation of particulate exogenous antigens (phagosomes) | CYBB;CYBA |
Immune System | GBP5;RAPGEF3;IFIT2;USP18;SOCS3A;CRP;HERC5;TRIM62;ACTR2B |
Leishmaniasis | HLA-DRB4;HLA-DQB1;NFKBIA;PTPN6;TGFB1;NCF4;FCGR2A;PRKCB;FOS |
Leukocyte transendothelial migration | MMP9;ITGB2L;TXK;CLDN20;MYLPF;PRKCA;ROCK1;RAC2;CLDN23 |
Osteoclast differentiation | LILRB4;CSF1R;CYBB;TGFB1;SIRPB1;RELB;NFKB2;CSF1;CYLD |
CYBA has several biochemical functions, for example, SH3 domain binding, electron carrier activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYBA itself. We selected most functions CYBA had, and list some proteins which have the same functions with CYBA. You can find most of the proteins on our site.
Function | Related Protein |
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SH3 domain binding | LANCL1;SH3BGRL;CNTNAP1;QKI2;ADAM12;FMN1;GJA1;QKI;ITGB1BP2 |
electron carrier activity | HSD17B6;TXNRD1;ETFDH;ALDH4A1;SDHB;CYBA;PRKRA;ALDH2;GCDHA |
heme binding | SDHD;CYGB;CYP2F1;CYP4F3;HBB-BH1;HBBE1.1;CYP2W1;CYGB2;GUCY1B3 |
metal ion binding | LNX2;RORAB;ZBBX;ZBTB16;MEP1A.1;ZNRF3;TENC1;FCER2;ZC3H13 |
protein binding | ZFYVE9;TAX1BP3;ASMTL;DULLARD;SLC52A2;HYI;PAM;CD8B1;CTNNAL1 |
protein heterodimerization activity | TWIST1;NFYC;H2AFY;DVL3;CUL3;PDGFB;DRD2;TLR6;TGFB3 |
contributes_to superoxide-generating NADPH oxidase activity | CYBA;CYBB |
CYBA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYBA here. Most of them are supplied by our site. Hope this information will be useful for your research of CYBA.
NCF1; NOXO1; MDFI; NCF4; CPT1A; RCHY1; MYC
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