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CYCS

  • Official Full Name

    cytochrome c, somatic

  • Overview

    This gene encodes a small heme protein that functions as a central component of the electron transport chain in;mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons;from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of;apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous;processed pseudogenes of this gene are found throughout the human genome.
  • Synonyms

    CYCS; cytochrome c, somatic; cytochrome c; HCS; CYC; THC4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Chicken
  • Equine
  • Human
  • Mouse
  • Rat
  • Bovine Heart
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Horse Heart
  • In Vitro Cell Free System
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYCS-290H Recombinant Human CYCS protein, His/MBP-tagged E.coli His/MBP 1-105 aa
Human CYCS-193H Recombinant Human CYCS Mammalian Cell His
Human CYCS-75H Recombinant Human CYCS, His-tagged E.coli His
Human CYCS-7135HCL Recombinant Human CYCS 293 Cell Lysate HEK293 N/A
Human CYCS-2764H-B Recombinant Human CYCS Protein Pre-coupled Magnetic Beads HEK293
Human CYCS-2400HF Recombinant Full Length Human CYCS Protein, GST-tagged In Vitro Cell Free System GST 105 amino acids
Human CYCS-1296H Recombinant Human CYCS Protein, His-tagged E.coli N-His Gly2-Glu105
Human CYCS-3137H Recombinant Human CYCS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CYCS-2764H Recombinant Human CYCS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CYCS-2782H Recombinant Human CYCS protein, GST-tagged E.coli GST 2-105aa
Human CYCS-2140H Recombinant Human CYCS Protein (Met1-Glu105), N-His tagged E.coli N-His Met1-Glu105
Mouse CYCS-4135M Recombinant Mouse CYCS Protein Mammalian Cell His
Mouse CYCS-2120M-B Recombinant Mouse CYCS Protein Pre-coupled Magnetic Beads HEK293
Mouse CYCS-2120M Recombinant Mouse CYCS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CYCS-78M Recombinant Mouse CYCS Protein, His-tagged E. coli His Gly2-Glu105
Mouse CYCS-79M Recombinant Mouse CYCS Protein, His-tagged E. coli His aa13-99
Mouse Cycs-2406M Recombinant Mouse Cycs Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CYCS-1709R Recombinant Rat CYCS Protein Mammalian Cell His
Rat CYCS-1368R Recombinant Rat CYCS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CYCS-1368R-B Recombinant Rat CYCS Protein Pre-coupled Magnetic Beads HEK293
Bovine CYCS-17B Native Bovine Cytochrome C Protein Bovine Heart N/A
Equine CYTC-168E Native Horse Cytochrome C Horse Heart N/A
Chicken CYCS-3518C Recombinant Chicken CYCS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CYCS involved in several pathways and played different roles in them. We selected most pathways CYCS participated on our site, such as Sulfur metabolism, Metabolic pathways, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYCS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sulfur metabolismSUOX;PAPSS2;MPST;cysH;BPNT1;PAPSS2A;PAPSS2B;ETHE1;CYCS
Metabolic pathwaysAGXT2L1;ACOT1;TK1;DHRS4L2;CYP17A1;HSD17B4;HPD;CCBL2;ITPA
p signaling pathwayCasp3;CCND2;CCNE1;SHISA5;PTEN;PPM1DB;APAF1;CCNE2;RPRMA
ApoptosisPKP1;NFKBIAB;PRKACB;FASLG;FAS;IKBKB;CRADD;DIABLO;TNFSF10
Non-alcoholic fatty liver disease (NAFLD)NDUFA12;NDUFA2;UQCRH;LEP;NDUFS2;NDUFS1;CASP7;COX4I2;Casp3
Alzheimers diseaseATP5O;NDUFB4;COX4I1;ATP5F1;Atp5g2;ITPR2;NDUFS3;UQCRC2;NDUFAB1
Parkinsons diseaseSDHC;UBE2L3;DRD1A;NDUFA2;CYCS;UQCRFS1;NDUFB8;mt-Atp8;NDUFB7
Amyotrophic lateral sclerosis (ALS)CAT;PPP3CB;NEFL;MAP3K5;TRP53;SOD1;Casp3;BCL2;DERL1
Huntingtons diseaseEP300;NDUFB10;NDUFA13;POLR2F;NDUFC1;NDUFV3;POLR2K;TAF4B;REST
LegionellosisPYCARD;HSPA8;CASP7;IL-8;IL12B;NFKB2;HSPA6;CXCL2;SAR1A
ToxoplasmosisMYD88;IL10RB;GNAI2;TNFRSF1A;ITGB1;ALOX5;XIAP;STAT3;HSPA2
TuberculosisRFX5;HSPA9;STAT1;NFYB;PPP3R2;IFNA14;IL12A;PPP3CA;SRC
Hepatitis BMAPK8;PRKCG;RELA;TICAM2;CREB5;IFNA5;ATF4;PIK3CB;IRF7
Influenza AMYD88;BLB2;IFNA21;DNAJC3;MAVS;SOCS3;MAPK11;PRSS3;MAP2K1
Herpes simplex infectionPPP1CB;HLA-DQA2;IKBKB;PER1A;HLA-A;OAS2;TRAF1;Fasl;TNFSF14
Pathways in cancerFGFR1;RELA;FGF17;PLD1;CKS2;VEGFB;GSTP1;GLI3;AGTR1B
Colorectal cancerTCF7L2;BAX;APC2;MAPK10;PIK3R3;TGFB2;CCND1;APPL1;RALGDS
Small cell lung cancerBIRC7;NOS2;RB1;NFKB1;TRAF1;BCL2L1;LAMC2;CCNE1;PTGS2
Viral myocarditisCD28;ITGB2L;ABL1;HLA-DQB1;HLA-G;CD80;HLA-E;HLA-DRB4;HLA-DMB

CYCS has several biochemical functions, for example, electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity, heme binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYCS itself. We selected most functions CYCS had, and list some proteins which have the same functions with CYCS. You can find most of the proteins on our site.

Function Related Protein
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
heme bindingNOS1;CYP2C54;CYP2K18;CYP8B1;DGCR8;CYP46A1.4;TDO2;HEBP1;CYP2J6
metal ion bindingACLYA;LONRF1L;FGD4;MAZ;TOE1;DNTT;CACNA2D3;EXTL3;IDS
protein bindingSTXBP3;PLEKHF1;ZCCHC12;ADH1A;RPL22;ENSA;GDF7;EIF3E;BCL11B
contributes_to protein serine/threonine phosphatase activityPPP2CB;CYCS

CYCS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYCS here. Most of them are supplied by our site. Hope this information will be useful for your research of CYCS.

APAF1; TRAF6; KRT40; CYC12; MT-CO1; GH1; EPB41; MCC; HLA-B; VHL; CASP9

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is the release of CYCS from mitochondria regulated? 12/07/2022

Bcl-2 family proteins regulate CYCS release, balancing pro- and anti-apoptotic signals.

What is the role of CYCS in apoptosis? 08/21/2022

In apoptosis, CYCS activates caspases after being released into the cytosol.

How does CYCS contribute to mitochondrial function? 04/16/2022

It transports electrons in the mitochondrial respiratory chain, aiding ATP production.

What happens when there is dysregulation in CYCS activity? 03/19/2022

Dysregulated CYCS activity can lead to impaired cellular energy production or excessive cell death.

What is the primary biological role of CYCS in cellular processes? 09/06/2021

CYCS is crucial for electron transport in mitochondria and inducing apoptosis.

How is CYCS implicated in various diseases? 03/28/2021

Alterations in CYCS are linked to various diseases, including neurodegenerative conditions and cancer.

Are there any therapeutic strategies targeting CYCS? 11/07/2018

Therapeutic strategies may aim to modulate CYCS activity, influencing apoptosis in diseases like cancer.

Customer Reviews (3)

Write a review
Reviews
05/07/2022

    Excellent for cell experiments.

    07/01/2021

      Good concentration, easy handling.

      12/03/2020

        Quick shipping, great condition.

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