TRAF4
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Official Full Name
TNF receptor-associated factor 4
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Overview
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. -
Synonyms
TRAF4; TNF receptor-associated factor 4; CART1; MLN62; RNF83; MLN 62; malignant 62; RING finger protein 83; metastatic lymph node gene 62 protein; tumor necrosis receptor-associated factor 4A; cysteine-rich domain associated with ring and TRAF domain; cys;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- GST
- GST|His
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | TRAF4-3387H | Recombinant Human TRAF4, GST-tagged | E.coli | GST | 35-307AA | |
Human | TRAF4-550H | Recombinant Human TRAF4 Protein, GST-His-tagged | E.coli | GST/His | ||
Human | TRAF4-31602TH | Recombinant Human TRAF4, His-tagged | E.coli | His | ||
Human | TRAF4-820HCL | Recombinant Human TRAF4 293 Cell Lysate | HEK293 | N/A | ||
Human | TRAF4-558H | Recombinant Human TRAF4 Protein, His-tagged | E.coli | His | Gln193~Asp444 | |
Human | TRAF4-6711H | Recombinant Human TRAF4 Protein (Gln193-Asp444), His tagged | E.coli | His | Gln193-Asp444 | |
Mouse | TRAF4-17289M | Recombinant Mouse TRAF4 Protein | Mammalian Cell | His | ||
Mouse | TRAF4-9558M-B | Recombinant Mouse TRAF4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | TRAF4-9558M | Recombinant Mouse TRAF4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
TRAF4 involved in several pathways and played different roles in them. We selected most pathways TRAF4 participated on our site, such as Pathways in cancer, Small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Pathways in cancer | HDAC2;FZD7;NCOA4;WNT5B;RUNX1;WNT9A;LAMA5;PTGER1;WNT7B |
Small cell lung cancer | FHIT;LAMA3;FN1;CYCS;TRAF1;RARB;LAMA2;CKS2;IKBKG |
TRAF4 has several biochemical functions, for example, DNA binding, WW domain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF4 itself. We selected most functions TRAF4 had, and list some proteins which have the same functions with TRAF4. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZFP1;RARGA;NR1D1;ZNF547;DDX3Y;HIST1H2BA;VEPH1;CDKN2A;SIX6 |
WW domain binding | TCEAL3;TRAF4;KIF20B;TNK2;PPARG;TCEAL5;DAZAP2;PMEPA1;ATCAY |
protein binding | F8;APPBP2;CASQ2;CAPNS1;MED9;PCOLCE;ATG5;KCNH2;CUEDC2 |
protein kinase binding | FGFR1OP;GATA6;CCNT2A;PIFO;SQSTM1;SPDYB;CDC25A;PARK2;ZFP36 |
thioesterase binding | TRAF4;TRAF3;CALM3;TRAF2;HAUS7;ARF6;ADRA2A;TRAF1;TRAF5 |
tumor necrosis factor receptor binding | TRIM37;TNFSF10;Fasl;TNF;TNFSF9;TNFB;TRAF1;CD70;TNFSF14 |
ubiquitin protein ligase binding | FZD6;CD40;UBE2R2;CUL5A;TMEM189;SMAD5;RNF31;PRR5L;NFKBIA |
ubiquitin-protein transferase activity | BRCA1;SMURF1;UBE2C;TRAF4;MYLIP;ARIH1;RNF144AA;WWP2;TRIP12 |
zinc ion binding | GTF2H2C_2;ADAMTS15;NR4A2A;ZSWIM4;TRIM8A;BAZ2B;MTF2;BRD1;UHRF2 |
TRAF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF4.
WWP2; BYSL; SMURF1; BCL6B; NPIPA7
- Q&As
- Reviews
Q&As (5)
Ask a questionTRAF4 may serve as a biomarker for certain types of cancer, and targeting TRAF4 signaling pathways could be a potential strategy for cancer therapy.
TRAF4 is involved in signaling pathways that regulate immune responses, and its dysregulation has been linked to inflammatory and autoimmune conditions.
Several research studies are exploring the role of TRAF4 in autoimmune diseases, with the goal of identifying potential therapeutic targets.
TRAF4 has been implicated in promoting the growth and metastasis of certain types of cancer, including breast and prostate cancer.
Research suggests that TRAF4 expression levels may be used as a diagnostic marker for certain types of cancer, aiding in early detection and prognosis.
Customer Reviews (3)
Write a reviewThey have a deep understanding of the TRAF4 protein and can provide valuable insights into its characteristics, properties, and optimal experimental conditions.
This guidance can help researchers design and execute their experiments more effectively, ensuring reliable and accurate results.
the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.
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