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CACNA1C

Official Full Name

Calcium Channel, Voltage-Dependent, L Type, Alpha 1C Subunit
Overview

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Specifically, Cav1.2 is a cardiac L-type calcium channel and is important for excitation and contraction of the heart. It may be associated with a variant of Long QT syndrome called Timothy’s syndrome and also with Brugada syndrome. Some references suggest it is related to bipolar disease as well.
Synonyms

CACNA1C; Cav1.2 Calcium Channel; calcium channel, voltage-dependent, L type, alpha 1C subunit; TS; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1; MGC120730; voltage-dependent L-type calcium channel subunit alpha-1C; DHPR, alpha-1 subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*; Voltage-gated calcium channel subunit alpha Cav1.2; OTTHUMP00000196730; OTTHUMP00000196731; OTTHUMP00000196732; OTTHUMP00000196733; OTTHUMP00000196734; OTTHUMP00000196735; OTTHUMP00000196736; OTTHUMP00000196737; OTTHUMP00000196738; OTTHUMP00000196739; OTTHUMP00000196740; OTTHUMP00000196741; OTTHUMP00000196742; OTTHUMP00000196743; OTTHUMP00000196744; OTTHUMP00000196745; OTTHUMP00000196746; OTTHUMP00000196747; OTTHUMP00000196748; OTTHUMP00000196749; OTTHUMP00000196750; OTTHUMP00000196751; OTTHUMP00000238277; OTTHUMP00000238278; OTTHUMP00000238279;

Type

Recombinant Proteins

Species

Cavia porcellus (Guinea pig)
Gallus gallus (Chicken)
Guinea pig
Human
Mouse
Zebrafish

Source

E.coli
E.coli expression system
In vitro E. coli expression system
Mammalian Cell
Wheat Germ

Tag

GST
His
His|T7

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CACNA1C-0264H	Recombinant Human CACNA1C Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Mouse	Cacna1c-1423M	Recombinant Mouse Cacna1c protein, His & T7-tagged	E.coli	His/T7	Ser1978~Leu2139 (Accession # Q01815)	Inquiry
Cavia porcellus (Guinea pig)	RFL29137CF	Recombinant Full Length Guinea Pig Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C(Cacna1C) Protein, His-Tagged	E.coli expression system	His	Full Length (1-169aa)	Inquiry
Gallus gallus (Chicken)	RFL11969GF	Recombinant Full Length Chicken Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C(Cacna1C) Protein, His-Tagged	E.coli expression system	His	Full Length (1-177)	Inquiry
Guinea pig	CACNA1C-01G	Recombinant Guinea pig CACNA1C Full Length Transmembrane protein, His-tagged	In vitro E. coli expression system	His	1-169aa	Inquiry
Zebrafish	CACNA1C-9399Z	Recombinant Zebrafish CACNA1C	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CACNA1C Related Articles

CACNA1C involved in several pathways and played different roles in them. We selected most pathways CACNA1C participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	Fgf15;JUND;RASGRF2B;GNG12A;CACNG8;CACNB3;FGFR1A;NLK1;MAP4K1
Calcium signaling pathway	P2RX7;ERBB4A;MYLK;LHCGR;PHKG1;ATP2B1;PLCG1;STIM1;GNA15.4
Cardiac muscle contraction	CACNA2D2;MYL4;UQCRB;COX5AA;CACNB2;COX4I2;CACNA2D4;UQCRC2A;COX8C
Adrenergic signaling in cardiomyocytes	MYH15;CACNB4;PPP2R5EB;PPP2R5A;CALM4;MAPK12B;AGTR2;PRKACAB;GNAQ
Vascular smooth muscle contraction	CALCRLA;AGTR1A;CACNA1C;ROCK2;PPP1R12A;PTGIR;PLCB2;CALM1;PLA2G4C
GnRH signaling pathway	LHB;MAP2K4B;MAPK12A;MAP2K1;MAP2K2;ADCY1B;EGFRA;ITPR1;PRKCDA

CACNA1C has several biochemical functions, for example, calcium channel activity, high voltage-gated calcium channel activity, ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1C itself. We selected most functions CACNA1C had, and list some proteins which have the same functions with CACNA1C. You can find most of the proteins on our site.

Function	Related Protein
calcium channel activity	TRPC1;TRPV3;TRPC7A;PSEN1;RYR2;TRPC2;TRPC7B;TRPV6;CUL5
high voltage-gated calcium channel activity	CACNB3A;CACNA1BA;CACNB2B;CACNA1B;CACNB3;CACNA1SA;CACNB2A;CACNA1SB;CACNA1C
ion channel activity	CLCN4-2;CNGA4;GRIA3B;ASIC4;SCN11A;KCNF1A;P2RX3B;KCNC3A;ITPR3
voltage-gated calcium channel activity	CACNG2B;CACNB2A;GAS6;CACNA1BA;TMC1;PKD2;CACNA2D1;CACNB4B;CACNG7
voltage-gated ion channel activity	CLCNKB;KCNH5;KCNS3B;CLIC1;SCN12AA;KCNJ1A.3;KCNA2B;KCNC1A;KCNC2

CACNA1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1C here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1C.

Wenzel, K; Haase, H; et al. Potential Relevance of alpha(1)-Adrenergic Receptor Autoantibodies in Refractory Hypertension. PLOS ONE 3:-(2008).