Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

CACNB1

  • Official Full Name

    calcium channel, voltage-dependent, beta 1 subunit

  • Overview

    Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Calcium channel, voltage-dependent, β1 subunit, also known as CACNB1, is a human gene. The protein encoded by this gene belongs to the calcium channel β subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the α1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
  • Synonyms

    CACNB1; calcium channel, voltage-dependent, beta 1 subunit; CACNLB1; voltage-dependent L-type calcium channel subunit beta-1; calcium channel, L type, beta 1 polypeptide; calcium channel voltage-dependent subunit beta 1; dihydropyridine-sensitive L-type,;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mouse
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CACNB1-26767TH Recombinant Human CACNB1, His-tagged E.coli His
Human CACNB1-0270H Recombinant Human CACNB1 Protein, GST-Tagged Wheat Germ GST
Human CACNB1-7903HCL Recombinant Human CACNB1 293 Cell Lysate HEK293 N/A
Human CACNB1-2961HF Recombinant Full Length Human CACNB1 Protein, GST-tagged In Vitro Cell Free System GST 598 amino acids
Human CACNB1-2262H Recombinant Human CACNB1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CACNB1-6188H Recombinant Human CACNB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse CACNB1-2619M Recombinant Mouse CACNB1 Protein Mammalian Cell His
Mouse Cacnb1-736M Recombinant Mouse Cacnb1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CACNB1-1173M Recombinant Mouse CACNB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CACNB1-1173M-B Recombinant Mouse CACNB1 Protein Pre-coupled Magnetic Beads HEK293
Rat CACNB1-1068R Recombinant Rat CACNB1 Protein Mammalian Cell His
Rat CACNB1-732R-B Recombinant Rat CACNB1 Protein Pre-coupled Magnetic Beads HEK293
Rat CACNB1-732R Recombinant Rat CACNB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DMABT-H12623 Mouse Anti-Cacnb1 Monoclonal Antibody Mouse N/A
Zebrafish CACNB1-762Z Recombinant Zebrafish CACNB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CACNB1 Related Articles

CACNB1 involved in several pathways and played different roles in them. We selected most pathways CACNB1 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayTGFBR1;NLK;PPM1AA;MAP3K5;HRASA;FGF22;PPM1BB;DUSP3;PRKACAA
Cardiac muscle contractionCACNG6;CACNA1C;ATP1B1;SLC9A1;CACNA2D1A;UQCRQ;SLC8A1;CACNG4;CACNB1
Adrenergic signaling in cardiomyocytesPIK3CA;PIK3R3A;PPP2R5E;MAPK1;TNNC1;CAMK2B;PIK3R3;MAPK14B;Adcy4
Oxytocin signaling pathwayNOS3;PIK3R2;PPP1CB;MAPK7;NFATC4;KRAS;CALML3;CACNA2D3;GNAQ
Hypertrophic cardiomyopathy (HCM)SGCA;ITGA2;ITGB8;RYR2;ITGA1;CACNG4;CACNB3;TTN;LMNA
Arrhythmogenic right ventricular cardiomyopathy (ARVC)CACNG1;ACTN2;SGCD;DMD;LAMA2;CDH2;DSP;SGCG;CACNB1
Dilated cardiomyopathyITGB1;SGCB;ITGA7;TNNC1;SGCD;SLC8A1;TTN;SGCG;ITGA2B

CACNB1 has several biochemical functions, for example, high voltage-gated calcium channel activity, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNB1 itself. We selected most functions CACNB1 had, and list some proteins which have the same functions with CACNB1. You can find most of the proteins on our site.

Function Related Protein
high voltage-gated calcium channel activityCACNA1SA;CACNB1;CACNB4A;CACNA1SB;CACNB3A;CACNA1BA;CACNB4B;CACNA1B;CACNA1C
voltage-gated calcium channel activityCACNA1BA;TPCN2;CACNG2;CACNG7A;CACNA1DA;CACNG7;CACNG2A;TPC3;CACNA2D2

CACNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNB1.

GEM; ATN1

Gaber, EM; Jayaprakash, P; et al. Effects of a sucrose-enriched diet on the pattern of gene expression, contraction and Ca2+transport in Goto-Kakizaki type 2 diabetic rat heart. EXPERIMENTAL PHYSIOLOGY 99:881-893(2014).
Salem, KA; Adrian, TE; et al. Shortening and intracellular Ca2+in ventricular myocytes and expression of genes encoding cardiac muscle proteins in early onset type 2 diabetic Goto-Kakizaki rats. EXPERIMENTAL PHYSIOLOGY 97:1281-1291(2012).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does CACNB1 modulate the activity of calcium channels? 01/01/2019

CACNB1 can enhance the open probability of associated calcium channels, thereby modulating calcium influx into cells.

Have any specific diseases been linked to CACNB1 dysfunction or mutation? 12/21/2018

Dysfunctions or mutations in CACNB1 have been linked to certain cardiac and neurological disorders.

Are there other proteins or co-factors that interact with CACNB1 to regulate its function? 09/08/2018

CACNB1 interacts with the alpha-1 subunit of calcium channels, and potentially other regulatory proteins, to modulate channel activity.

Are there any known genetic mutations in the CACNB1 gene that impact channel regulation or other functions? 05/14/2018

Certain mutations in the CACNB1 gene can lead to altered channel activity, potentially causing or contributing to disease states.

What is the primary function of CACNB1 in relation to voltage-gated calcium channels? 05/11/2018

CACNB1 acts as an auxiliary subunit of voltage-gated calcium channels, modulating their activity and surface expression.

In which specific human tissues or cell types is CACNB1 most commonly expressed? 12/28/2017

CACNB1 is expressed in a variety of tissues, but it is particularly prevalent in the heart and central nervous system.

What post-translational modifications have been documented on CACNB1? 12/06/2016

Post-translational modifications like phosphorylation have been identified on CACNB1, which can influence its function and interactions.

Customer Reviews (3)

Write a review
Reviews
06/14/2022

    Fast turnaround, crucial for meeting project deadlines.

    12/28/2021

      Dependable source for all our protein research needs.

      05/12/2021

        Efficient sample handling, simplifies our workflow.

        Ask a Question for All CACNB1 Products

        Required fields are marked with *

        My Review for All CACNB1 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends