CALM2
-
Official Full Name
calmodulin 2 (phosphorylase kinase, delta)
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CALM2 Related Signal Pathway
CALM2 involved in several pathways and played different roles in them. We selected most pathways CALM2 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CALM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | RAF1;FGF13;RHOA;PLA2G2A;ZAP70;RASGRP3;RASSF5;STK4;MET |
| Rap signaling pathway | GNAQ;MET;PIK3R2;HGF;FGF11;ARAP3;NRAS;KRAS;GNAO1 |
| Calcium signaling pathway | CALM3B;Adcy4;TRHRB;CALM3;AGTR1A;RYR1;ATP2A3;CHRNA7;ATP2A2A |
| cGMP-PKG signaling pathway | SLC25A6;PPP1R12A;ATP2A2;INS2;NFATC3;PLCB1;ATP1B4;MEF2A;PPP3CB |
| cAMP signaling pathway | GRIN3B;GABBR2;RRAS;EP300;MAPK3;SLC9A1;ATP2A2;VAV2;NPY1R |
| Phosphatidylinositol signaling system | PIP4K2A;PIP5K1A;PLCD3A;MTMR1;DGKZ;PIK3C3;IMPAD1;CALM3A;PIK3R3A |
| Oocyte meiosis | RPS6KA2;ITPR1;CDK1;CTH1;PRKACAB;CUL1B;CPEB3;PPP1CB;YWHABB |
| Adrenergic signaling in cardiomyocytes | SCN1BB;ATP1B1B;PPP2R5CB;ATP1A1B;MYL3;CACNG6;ATF2;PRKACG;TPM4A |
| Vascular smooth muscle contraction | ROCK2;CACNA1SA;PLA2G2E;PPP1CC;GNA15.1;PLA2G5;CALM4;PLCB3;RHOA |
| Circadian entrainment | PRKG2;GNAI2;AKR1C1;PLCB2;NOS1;KCNJ5;CALM1;GNG7;PLCB4 |
| Long-term potentiation | RAP1B;CALML3;EP300;PPP3CB;ATF4;RPS6KA6;PRKCA;GRIN2D;RAF1 |
| Neurotrophin signaling pathway | PIK3CA;NFKB1;KIDINS220;RPS6KA1;BCL2;FOXO3;ARHGDIB;BDNF;TRP53 |
| Dopaminergic synapse | PPP3CC;CREB3L3;PPP2CA;PRKCG;PRKCA;KCNJ6;CREB3L4;GNG2;PPP2R2C |
| Olfactory transduction | CALM4;PRKG1;PDC;GNG7;OLFR5;OR10J1;OLFR481;PRKACA;OLFR492 |
| Phototransduction | CALM1B;CALM3;GRK7B;GNGT1;CALML5;GNB1B;GUCY2E;GUCY2F;CNGA1 |
| Inflammatory mediator regulation of TRP channels | HRH1;TRPA1;PLA2G4A;PIK3CG;CALM2;CYP2J6;CYP4A14;GNAQ;ALOX12E |
| Insulin signaling pathway | SHC1;PPP1R3DA;MAP2K2;MAP2K1;PRKACAA;SOCS3B;PIK3R3B;PYGL;GSK3B |
| GnRH signaling pathway | CDC42;PLA2G4F;MAP2K4;MMP14;MMP2;CAMK2G;ATF4;PLD2;ADCY1A |
| Estrogen signaling pathway | MAP2K1;MAPK1;GRM1;MMP9;SHC3;SP1;FKBP4;GABBR1;SHC1 |
| Melanogenesis | GNA15.4;EDNRBA;CAMK2G1;PRKACAB;WNT2BB;CALM3A;GSK3AA;CALML5;WNT7AA |
| Oxytocin signaling pathway | CACNG1;PPP1R12C;PLA2G4F;OXTR;PRKAG3;MAPK1;MAPK3;TRPM2;PRKAB1 |
| Renin secretion | GNAI3;CLCA1;AQP1;ITPR1;PDE1A;ACE;LOC100328615;GNAI1;PLCB1 |
| Aldosterone synthesis and secretion | NETO2;GNAQ;LDLR;ADCY7;PLCB1;PRKCA;CAMK2A;CAMK1D;PRKCB |
| Salivary secretion | AQP5;MUC7;PRB1;GNAQ;LYZ;GUCY1A3;ATP1A1;FXYD2;PRKCG |
| Gastric acid secretion | GNAI1;MYLK3;MYLK4;KCNK2;MYLK;CALM3;SLC26A7;CAMK2B;SSTR2 |
| Alzheimers disease | PSEN1;APH1B;HSD17B10;NDUFA9;NOS1;BACE2;APAF1;CAPN1;APOE |
| Alcoholism | CREB3;HIST1H2AJ;ADORA2A;DRD1;GNG13;HIST2H2AC;CALM3;HIST1H4H;H2AFB1 |
| Pertussis | IL12A;ITGB1;TLR4;CASP7;MYD88;GNAI1;IL12B;CALM3;IRAK1 |
| Tuberculosis | FCGR2B;IL1B;CAMK2A;IFNGR1;IL1A;IFNG;CYCS;TGFB1;CALM3 |
| Glioma | PIK3R1;CALM1;MAPK1;CALML3;RAF1;PIK3R5;PIK3CA;TRP53;AKT1 |
CALM2 has several biochemical functions, for example, N-terminal myristoylation domain binding, adenylate cyclase binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CALM2 itself. We selected most functions CALM2 had, and list some proteins which have the same functions with CALM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-terminal myristoylation domain binding | CALM2;CALM1;CALM3;CALM |
| adenylate cyclase binding | AKAP6;CALM3;AKAP12;ADRB2;ADCYAP1R1;CALM1;AKAP5;CHRNA7;CALM2 |
| calcium ion binding | CAPS;CDH7;SYT10;CAPSLB;NCS1B;EDEM2;STIM2;PCDH7;PLCB2 |
| calcium-dependent protein binding | SEC31A;ANXA3;A2M;ANXA7;PDCD6;CALM3;DDX5;VPS37B;NRXN1 |
| ion channel binding | LYN;PPP1R9B;CAV3;ANK2;BAK1;PKD1;EPN1;TRAPPC2;HSP90AB1 |
| nitric-oxide synthase binding | SLC6A4;ATP2B4;CALM1;DMD;SLC14A2;DNM2;CAV3;CALM3;CALM2 |
| nitric-oxide synthase regulator activity | HSP90AA1.1;CALM1;ESR1;HSP90AA1;AKT1;CALM3;CALM2;HSP90AB1 |
| phosphatidylinositol 3-kinase binding | PIK3R1;IGF1RB;INSR;IGF1R;INSRA;CALM3;FLT3;CALM2;IRS1 |
| phospholipase binding | SNCA;Pla2r1;PRKCZ;APOC2;CALM;SELE;PDPK1;WAS;CALM2 |
| protein binding | ZNF643;DLX2;ADAR;ALOX12B;PHF19;CARF;ATP5B;GLI3;MED25 |
| protein domain specific binding | YWHAG;MYH9;THRA;KCTD13;MYO1D;PKD1;CASKIN1;SERPINB1A;DDX20 |
| protein kinase binding | PRKAG1;KIF11;CCNT2B;TELO2;ACVRL1;RPS3;SMAD3;USF1;HCLS1 |
| protein phosphatase activator activity | CALM1;CALM3;B3GAT3;CALM;CALM2 |
| protein serine/threonine kinase activator activity | SPRY2;CALM3;STK4;ALS2;STK3;IGF2;MAP2K2;MAP2K1;FAM20A |
| thioesterase binding | ARF6;TRAF4;ADRA2A;TRAF2;HAUS7;RAC1;TRAF3;TRAF6;TRAF5 |
| titin binding | MYBPC1;OBSCN;SLC14A2;TCAP;ANKRD23;ANKRD1;ANKRD1B;CALM;CALM2 |
| type 3 metabotropic glutamate receptor binding | CALM1;CALM3;CALM2 |
CALM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CALM2.
cya; CCP110; EGFR
- Q&As
- Reviews
Q&As (5)
Ask a questionResearchers use techniques like NMR spectroscopy and X-ray crystallography to study CALM2's calcium binding. Understanding these interactions is crucial for elucidating calcium-regulated cellular events.
Dysregulation of CALM2 has been associated with cardiac arrhythmias and neuromuscular disorders, making it a focus of study for potential therapeutic interventions.
CALM2 is linked to neuromuscular disorders, and understanding this connection may provide insights into potential therapeutic strategies for these conditions.
CALM2 is involved in calcium-dependent signal transduction, modulating processes such as muscle contraction, enzyme activation, and neurotransmitter release.
CALM2 binds to and activates various enzymes and proteins in response to changes in calcium levels, regulating diverse cellular functions and maintaining homeostasis.
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