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CAPN10

Official Full Name

calpain 10
Overview

Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
Synonyms

CAPN10; calpain 10; CANP10; NIDDM1; calpain-10; calpain-like protease CAPN10; calcium-activated neutral proteinase 10;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Cynomolgus Monkey
Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CAPN10-29H	Recombinant Human CAPN10 Protein, GST-tagged	Wheat Germ	GST	1 a.a. - 672 a.a.	Inquiry
Human	CAPN10-276HCL	Recombinant Human CAPN10 cell lysate		N/A		Inquiry
Human	CAPN10-361H	Recombinant Human CAPN10 Protein, His-tagged	E.coli	N-His	Thr322-Gln654	Inquiry
Human	CAPN10-1745HF	Recombinant Full Length Human CAPN10 Protein, GST-tagged	In Vitro Cell Free System	GST	672 amino acids	Inquiry
Mouse	CAPN10-2691M	Recombinant Mouse CAPN10 Protein	Mammalian Cell	His		Inquiry
Mouse	Capn10-8175M	Recombinant Mouse Capn10 protein, His & T7-tagged	E.coli	His/T7	Ser22~Pro374 (Accession# Q9ESK3)	Inquiry
Mouse	CAPN10-1214M	Recombinant Mouse CAPN10 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	CAPN10-1214M-B	Recombinant Mouse CAPN10 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Cynomolgus Monkey	CAPN10-357C	Recombinant Cynomolgus CAPN10 Protein, His-tagged	Mammalian Cell	His		Inquiry
Cynomolgus Monkey	CAPN10-105C-B	Recombinant Cynomolgus Monkey CAPN10 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Cynomolgus Monkey	CAPN10-105C	Recombinant Cynomolgus Monkey CAPN10 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CAPN10 Related Articles

CAPN10 involved in several pathways and played different roles in them. We selected most pathways CAPN10 participated on our site, such as Integrin-mediated cell adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPN10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Integrin-mediated cell adhesion	CAPN3;MAPK6;CAPN9;MAPK4;CAPNS1;SEPP1A;SEPP1;CAPN11;TNS1

CAPN10 has several biochemical functions, for example, SNARE binding, calcium-dependent cysteine-type endopeptidase activity, cytoskeletal protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPN10 itself. We selected most functions CAPN10 had, and list some proteins which have the same functions with CAPN10. You can find most of the proteins on our site.

Function	Related Protein
SNARE binding	STX4;STX2A;STX5A;STX5AL;STX1A;VAMP5;ANKRD27;STX1B;VAMP8
calcium-dependent cysteine-type endopeptidase activity	CAPN3B;CAPN3A;CAPN3;CAPN2A;CAPN9;CAPNS1B;CAPN1B;CAPN2B;CAPN13
cytoskeletal protein binding	CAPN2;PTPN3;FABP3;PTPN4;Fert2;PTPN4B;PTPN4A;FRMD3;FRMD5

CAPN10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPN10 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPN10.

SHD; PSMA7; FLOT1; EFNB1; FANCC

Fukuta, S; Miyamoto, K; et al. Abundance of calpain and aggrecan-cleavage products of calpain in degenerated human intervertebral discs. OSTEOARTHRITIS AND CARTILAGE 19:1254-1262(2011).

Reifert, J; Hartung-Cranston, D; et al. Amyloid beta-Mediated Cell Death of Cultured Hippocampal Neurons Reveals Extensive Tau Fragmentation without Increased Full-length Tau Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 286:20797-20811(2011).