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CAPN12

Official Full Name

calpain 12
Overview

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]
Synonyms

CAPN12; calpain 12; calpain-12; CANP 12; calcium-activated neutral proteinase 12;

Type

Recombinant Proteins

Species

Human
Mouse
Zebrafish

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CAPN12-390H	Recombinant Human CAPN12 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	CAPN12-0359H	Recombinant Human CAPN12 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CAPN12-2817HF	Recombinant Full Length Human CAPN12 Protein, GST-tagged	In Vitro Cell Free System	GST	719 amino acids	Inquiry
Human	CAPN12-3242H	Recombinant Human CAPN12 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Capn12-1951M	Recombinant Mouse Capn12 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	CAPN12-5372Z	Recombinant Zebrafish CAPN12	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CAPN12 Related Articles

CAPN12 involved in several pathways and played different roles in them. We selected most pathways CAPN12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPN12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

CAPN12 has several biochemical functions, for example, calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPN12 itself. We selected most functions CAPN12 had, and list some proteins which have the same functions with CAPN12. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	SYT1;TPD52;PKD1L2;MYL6B;CDH18A;MICU2;CAPN1B;MYLPFA;BMP1A
calcium-dependent cysteine-type endopeptidase activity	CAPNS1B;CAPN2A;CAPN3A;CAPN5;CAPN1;CAPN2B;CAPN3B;CAPNS1A;CAPN5A
cysteine-type peptidase activity	CTSL2;SOLH;PIGK;CAPN12;CAPN3;OTUD6B;UFSP2;CASP7;CTSL1B
hydrolase activity	NUDT19;RHOT1B;METAP2B;PPTC7A;INPPL1B;MOV10B.1;DPYSL5B;F2RL1.2;ABHD13
peptidase activity	MMP13A;GM5077;REN;MALT1;C6AST1;SHHB;MCPT9;REN2;TMPRSS7

CAPN12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPN12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPN12.

Comitato, A; Sanges, D; et al. Activation of Bax in Three Models of Retinitis Pigmentosa. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:3555-3561(2014).

Samanta, S; Ghoshal, A; et al. Sialoglycosylation of RBC in Visceral Leishmaniasis Leads to Enhanced Oxidative Stress, Calpain-Induced Fragmentation of Spectrin and Hemolysis. PLOS ONE 7:-(2012).