CASP9
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Official Full Name
caspase 9, apoptosis-related cysteine peptidase
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Overview
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] -
Synonyms
CASP9; caspase 9, apoptosis-related cysteine peptidase; MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; caspase-9; apoptotic protease MCH-6; ICE-like apoptotic protease 6; apoptotic protease activating factor 3; protein phosphatase 1, regulatory subunit 56;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- CASP9 Related Research Area
- CASP9 Related Signal Pathway
CASP9 involved in several pathways and played different roles in them. We selected most pathways CASP9 participated on our site, such as p signaling pathway, PIK-Akt signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p signaling pathway | PTENB;BAI1;PPM1DA;RPRMA;CCNB3;APAF1;SESN2;TP53AIP1;CASP8 |
| PIK-Akt signaling pathway | TSC2;INS1;IFNA5;CCNE1;IFNA12;NR4A1;GYS2;PPP2R3C;TNN |
| Apoptosis | VIML;PPP3R1B;DFFB;HMGB2A;PPP3CA;CAPN2B;IRF4;IL3;CASP3B |
| VEGF signaling pathway | CDC42;MAPK3;PTK2AA;PTGS2B;SPHK2;PLA2G4AA;PLCG2;AKT2;PIK3R1 |
| Thyroid hormone signaling pathway | PIK3CD;PRKCB;ACTG1;PLCB2;MED13;NOTCH1;KRAS;PLCZ1;DIO3 |
| Alzheimers disease | GAPDH;ATP2A2;IL1B2;CAPN1;NDUFA9;PSEN2;NDUFB9;APH1B;NDUFA10 |
| Parkinsons disease | MT-ND1;PPIF;NDUFA11;NDUFA9;SLC25A31;SNCAIP;SLC25A4;LRRK2;SDHD |
| Amyotrophic lateral sclerosis (ALS) | GRIA2;GRIN2A;MAP2K3;RAC1;GRIN2C;PPP3R1;GRIN2D;MAPK13;CAT |
| Huntingtons disease | SDHD;CREB3L3;NDUFA4L2;CASP8;ATP5H;DCTN1;DNAH11;NDUFV3;EP300 |
| Legionellosis | NAIP1;NAIP6;TLR5;EEF1A2;VCP;CASP9;IL6;Itgam&Itgb2;ITGAM |
| Toxoplasmosis | GNAI3;MAPK10;HSPA1A;LAMA5;PIK3R3;GNAI1;CASP9;IKBKG;MAP3K7 |
| Tuberculosis | TLR4;MAPK8;HLA-DQA1;IFNB1;H2-AA;FADD;LAMP2;BAD;CALM1 |
| Hepatitis B | PRKCA;BCL2;TP53;FADD;CREB3L2;PIK3CB;IKBKG;YWHAB;CASP10 |
| Influenza A | IL-8;HLA-DPA1;HLA-DOA;DNAJB1;RAE1;CXCL10;PRKCA;IRF3;Ccl12 |
| Pathways in cancer | TGFBR1;FGFR2;CSF3R;HDAC2;TRAF3;PTGER3;TRAF1;KIT;CCDC6 |
| Colorectal cancer | PIK3R5;TGFBR1;ARAF;MAPK8;DCC;MSH3;TCF7;AXIN1;BIRC5 |
| Pancreatic cancer | PIK3R5;PIK3R2;PIK3CD;PIK3CB;MAPK10;CDC42;TRP53;BCL2L1;PIK3R3 |
| Endometrial cancer | CASP9;HRAS;TP53;PIK3R1;TRP53;BRAF;FOXO3;PIK3R2;PTEN |
| Prostate cancer | CREB5;HSP90B1;PDGFB;IKBKG;PDPK1;SOS1;PDGFRA;HRAS;HSP90AA1 |
| Small cell lung cancer | LAMB3;TRAF6;TRAF4;BCL2L1;NOS2;MAX;ITGA2;PIK3R1;LAMC1 |
| Non-small cell lung cancer | PIK3R3;PIK3CD;MAPK1;TGFA;PLCG1;PLCG2;SOS1;RASSF5;EML4 |
| Viral myocarditis | HLA-DQA2;SGCG;Casp3;CD28;RAC3;HLA-G;HLA-DRB1;ABL1;ICAM1 |
CASP9 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP9 itself. We selected most functions CASP9 had, and list some proteins which have the same functions with CASP9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | PTPN22;NCKIPSD;DOCK4;DTX1;PLSCR4;CCDC6;ITGB1BP2;DRD4;CNTNAP1 |
| cysteine-type endopeptidase activity | CTSM;CTSW;CTSJ;UCHL1;CTSO;CASP6;CTSK;USP43;CASP9 |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway | CASP14;CASP9;CASP8;CFLAR;CFLARA;CASP8L1;CASP10;CASP2 |
| enzyme activator activity | CXCL1;ASAP2;GLC8;GTF3C4;GM749;SLX4;CTAGE5;PRKCD;PRKCE |
| peptidase activity | HPN;CASPB;PSD;ADAMTS4;BMP1;CAPN11;PM20D1.1;CTSLL;UFSP2 |
| protein binding | CTAG2;CPSF2;FRMPD1;IL6R;RUVBL2;KIAA1191;PKP4;TCEANC2;CD79B |
| protein kinase binding | TOM1L1;MAP2K6;PLK1S1;DCX;AXIN2;CCNA2;KCNH1;TP53;PRKACA |
CASP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP9.
XIAP; APAF1
- Q&As
- Reviews
Q&As (5)
Ask a questionDysregulation of CASP9 protein is associated with cancer, neurodegenerative diseases, and immune system disorders.
CASP9 protein is being investigated as a potential therapeutic target in autoimmune diseases to modulate immune cell apoptosis.
Dysregulation of CASP9 protein can lead to abnormal immune cell apoptosis, contributing to autoimmune diseases and immunodeficiency.
CASP9 protein is targeted using small molecule inhibitors and therapeutic antibodies to induce apoptosis in cancer cells.
Yes, genetic variations in the CASP9 gene can impact protein function and have been linked to disease susceptibility.
Customer Reviews (3)
Write a reviewIts purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.
Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.
The bands of proteins in Western Blotting experiments were very clear.
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