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CAV1

  • Official Full Name

    caveolin 1, caveolae protein, 22kDa

  • Overview

    The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
  • Synonyms

    CAV1; caveolin 1, caveolae protein, 22kDa; CAV, caveolin 1, caveolae protein, 22kD; caveolin-1; cell growth-inhibiting protein 32; CGL3; BSCL3; VIP21; MSTP085;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Dog
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CAV1-215H Recombinant Human CAV1 Protein, His-tagged E.coli His Ser2~Ser104
Human CAV1-26608TH Recombinant Human CAV1 protein, GST-tagged Wheat Germ GST
Human CAV1-10749H Recombinant Human CAV1, His-tagged E.coli His 11-179a.a.
Human CAV1-7822HCL Recombinant Human CAV1 293 Cell Lysate HEK293 N/A
Human CAV1-0872H Recombinant Human CAV1 Protein (Ser2-Ser104), His tagged E.coli His Ser2-Ser104
Human CAV1-0389H Active Recombinant Human CAV1 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Mouse Cav1-216M Recombinant Mouse Cav1 Protein, His/GST-tagged E.coli His/GST Ser2~Ser104
Mouse CAV1-2773M Recombinant Mouse CAV1 Protein Mammalian Cell His
Mouse CAV1-1258M-B Recombinant Mouse CAV1 Protein Pre-coupled Magnetic Beads HEK293
Mouse CAV1-1258M Recombinant Mouse CAV1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cav1-217R Recombinant Rat Cav1 Protein, His-tagged E.coli His Ser2~Thr105
Rat Cav1-2640R Recombinant Rat Cav1 protein, His&Myc-tagged E.coli His&Myc 2-178aa
Dog CAV1-5360D Recombinant Dog CAV1 protein, His-tagged Yeast His 1-178a
Zebrafish CAV1-2964Z Recombinant Zebrafish CAV1 Mammalian Cell His
Chicken CAV1-3752C Recombinant Chicken CAV1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CAV1 Related Articles
  • CAV1 Related Research Area

CAV1 involved in several pathways and played different roles in them. We selected most pathways CAV1 participated on our site, such as Endocytosis, Focal adhesion, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisRAB11A;SNX12;LDLRA;HGS;ARPC1A;PRKCZ;SNX4;PML;ASAP2A
Focal adhesionPTK2;GSK3B;SEPP1;ERBB2;ACTN3B;THBS4;ITGB1;HRASB;ARHGAP35
Bacterial invasion of epithelial cellsPIK3CA;CTTN;FN1;RHOA;SHC3;WAS;DNM1;ARPC5;SEPT12
Proteoglycans in cancerPPP1CB;PRKACB;PAK1;PIK3CG;PLCE1;PTCH1;WNT5B;PLCG1;KRAS
Viral myocarditisHLA-DPB1;CYCS;HLA-DRB1;CD40;H2-Q10;CD80;HLA-DRB4;RAC1;HLA-DOA

CAV1 has several biochemical functions, for example, ATPase binding, MDM2/MDM4 family protein binding, RNA polymerase I transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAV1 itself. We selected most functions CAV1 had, and list some proteins which have the same functions with CAV1. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingPEX26;ATPIF1A;WFS1;DRD1A;METTL21A;PKD2;PGR;GRIN2A;ATPIF1
MDM2/MDM4 family protein bindingCAV1;CDKN2A;RFWD3;TRP53;CDK5RAP3;PPARA;PSME3
RNA polymerase I transcription factor bindingCAV1;POLR1E
Rac GTPase bindingCDKL5;NCF2;FLNA;DOCK4;MAP3K11;NOX1;DVL1;SRGAP1;SRGAP2B
cholesterol bindingAPOA4B.1;ERLIN2;OSBPL3;PTCH1;APOA1;APOA4;OSBP2;OSBPL10;OSBPL7
enzyme bindingAPBA3;TBP;HAND1;CSF3;NOTCH3;HSPA8;TAF10;PLCB1;DAOA
identical protein bindingNDC80;CHMP4A;CAV1;TRIM39;PLIN5;BAX;EPHA4;DPP9;FRS3
inward rectifier potassium channel inhibitor activity
ion channel bindingDIAP1;AP2M1;PHPT1;KCNQ3;KCNH1;ID2;HOMER1;SCN3B;KCNE2
nitric-oxide synthase bindingSLC6A4;ATP2B4;NOS1AP;CD74;DMD;CALM3;ACTB;DNM2;CALM1
patched bindingCCNB1;CAV1;SMO;BBS1;Shh;IHH;PTCH1;SETD6;DHH
peptidase activator activityCAV1;APP;PCOLCE;PSME4;PINK1;MMP25;PSME4B;CLPX;MMP14
protein bindingLAMA4;SLC9A7;NSMCE2;NKX2-5;CCDC135;ZNF664-FAM101A;CREB1;cgr2b;TGM1
protein binding, bridgingSTX1A;LOR;TCAP;AMFR;CNTLN;FSCN1;BCL3;FGB;NEFH
protein complex scaffoldCNOT1;SEPT2;AKAP9;CAPN3;ARRB2;PKP2;SMARCD1;ITSN1;CAV3
protein heterodimerization activityIKBKG;MICU1;STX1A;POU5F3;MYO5A;FLOT2;DRAP1;BCL2L1;HIST1H2BN
protein kinase bindingCCNL2;CALM1;PPP1CB;KIF14;RAD9;PDCD10;PTPRJ;TEX14;GCSAM
receptor bindingMAP7;PECR;FGF8B;NXPH3;FGF20A;NPY;HSPA1A;CADM2;ADCYAP1
structural molecule activityCOL15A1B;SYNM;LMNB2;VCLA;CLDN8;SPRR2F;CLDNK;KRT12;KRT3
syntaxin bindingSTXBP3;SYT13;SYT10;RAB4A;CPLX2;SYT16;TXLNA;TXLNG;CXorf15

CAV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAV1.

PTPN1; EGFR; TXNRD1; ID1

Biswas, SK; Brako, L; et al. Massive formation of square array junctions dramatically alters cell shape but does not cause lens opacity in the cav1-KO mice. EXPERIMENTAL EYE RESEARCH 125:9-19(2014).
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Reviews
11/24/2019

    The pricing of protein reagents is reasonable, providing cost-effective options for various budgetary considerations.

    10/13/2017

      The quality of protein reagents remains stable and unaffected by environmental factors, ensuring consistent performance.

      11/13/2016

        Incorporating protein reagents reduces repetitive steps in experiments, ultimately enhancing efficiency.

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