cav1
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  • Official Full Name
  • caveolin 1, caveolae protein, 22kDa
  • Background
  • The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
  • Synonyms
  • CAV1; caveolin 1, caveolae protein, 22kDa; CAV, caveolin 1, caveolae protein, 22kD; caveolin-1; cell growth-inhibiting protein 32; CGL3; BSCL3; VIP21; MSTP085
Cat.#:CAV1-10749HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CAV1, His-tagged
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Cat.#:CAV1-215HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CAV1 Protein, His-tagged
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Cat.#:CAV1-26608THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CAV1 protein, GST-tagged
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Cat.#:Cav1-216MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cav1 Protein, His/GST-tagged
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Cat.#:CAV1-2773MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CAV1 Protein
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Cat.#:Cav1-217RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cav1 Protein, His-tagged
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Cat.#:CAV1-3752CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CAV1
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Cat.#:CAV1-2964ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CAV1
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Cat.#:CAV1-7822HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CAV1 293 Cell Lysate
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Cat.#:CSC-RK0173Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Lung Endothelial Cells
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Cat.#:CSC-RK0174Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Kidney Epithelial Cells
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Cat.#:CSC-RK0175Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Primary Intestinal Epithelial Cells
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Cat.#:CSC-RK0176Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Primary Stomach Epithelial Cells
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Cat.#:CSC-RK0177Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Primary Alveolar Epithelial Cells
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Cat.#:CSC-RK0178Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Heart Fibroblasts
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Cat.#:CSC-RK0179Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Spleen Fibroblasts
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Cat.#:CSC-RK0180Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Liver Fibroblasts
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Cat.#:CSC-RK0181Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Kidney Fibroblasts
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Cat.#:CSC-RK0182Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Lung Fibroblasts
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Cat.#:CSC-RK0183Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Bone Marrow Neutrophils
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Cat.#:CSC-RK0184Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Bone Marrow Leukocytes
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Cat.#:CSC-RK0185Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Bone Marrow Macrophages
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Cat.#:CSC-RK0186Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Bone Marrow Mesenchymal Stem Cells
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Cat.#:CSC-RK0187Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Embryonic Fibroblasts
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Cat.#:CSC-RK0188Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Heart Cells
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Cat.#:CSC-RK0189Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Spleen Cells
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Cat.#:CSC-RK0190Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Liver Cells
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Cat.#:CSC-RK0191Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Kidney Cells
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Cat.#:CSC-RK0192Tag:
Source (Host):Species:Mouse
Product nameCav1 Knockout Mouse Lung Cells
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Involved Pathway

CAV1 involved in several pathways and played different roles in them. We selected most pathways CAV1 participated on our site, such as Endocytosis, Focal adhesion, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
MHC1UXA2; PSD; SH3GLB1A; RAB5B; FGFR2; EPN1; FOLR3; TGFB2; SNX32; ARRB2A
Focal adhesion
MYLK; COL1A1B; COMP; CAPN2; PTENB; ITGB7; MYL9B; ITGA10; MYL12.2; PTENA
Bacterial invasion of epithelial cells
ITGA5; MAD2L2; ELMO2; SHC1; RHOA; CLTA; RAC1; SHC3; HCLS1; CBL
Proteoglycans in cancer
MAPK12; CAV2; HSPB2; PIK3CG; WNT7B; ACTB; SDC1; ARHGEF1; PRKACG; ARAF
Viral myocarditis
H2-Q10; HLA-DPA1; MYH7; ACTB; ICAM1; CXADR; ABL1; CD28; H2-AA; CYCS

Protein Function

CAV1 has several biochemical functions, for example, ATPase binding, MDM2/MDM4 family protein binding, RNA polymerase I transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAV1 itself. We selected most functions CAV1 had, and list some proteins which have the same functions with CAV1. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein FXYD7; DNAJB1; ATP6V0A4; S100A1; ABCA1; GRIN2A; GABARAPL2; FBL; ATP1B2; NUFIP1
Function MDM2/MDM4 family protein binding
Related Protein CDK5RAP3; RFWD3; CAV1; TRP53; PSME3; PPARA; CDKN2A
Function RNA polymerase I transcription factor binding
Related Protein POLR1E; CAV1
Function Rac GTPase binding
Related Protein RCC2; MAP3K11; PAK1; ARHGAP4; SRGAP2; RAB7A; EPS8; SOD1; PAK2A; PKN1
Function cholesterol binding
Related Protein NR1H3; OSBPL10; APOC3; APOD; OSBP2; STARD3; CYP11A1; APOA5; ERLIN2; OSBPL5
Function enzyme binding
Related Protein CNTNAP2; PTPLAD2; HDAC10; HAND2; SNRPD3; PPP3CB; KIAA1967; TRP53; UBE4B; DHCR24
Function identical protein binding
Related Protein CDC42; AMELX; GRB2; SLC22A1; NDC80; PTK6; TPRGL; PLIN5; NOL3; CLDN2
Function inward rectifier potassium channel inhibitor activity
Related Protein CAV1
Function ion channel binding
Related Protein PACS2; CAV1; ARRB1; CIB1; TCAP; KCNJ11; PHPT1; YWHAH; PACS1A; ABCC9
Function nitric-oxide synthase binding
Related Protein CAV3; SNTA1; CALM2; CALM3; SCN5A; CALM1; SLC6A4; CD74; DMD; CDH2
Function patched binding
Related Protein IHH; BBS1; Shh; CAV1; SETD6; DHH; PTCH1; CCNB1; SMO
Function peptidase activator activity
Related Protein PSME4; CLPX; APP; FN1; PCOLCE; MMP14; PSME4B; FBLN1; CAV1; PCOLCE2
Function protein binding
Related Protein MIS12; KLF5; HIST1H2AL; MID1; PRF1; ATP2B1; MAPRE1; TGS1; SF1; PLEKHG6
Function protein binding, bridging
Related Protein SYNM; ANXA1; BFAR; CAV2; FSCN1; IVL; NCK1; STUB1; FLRT2; FKBP4
Function protein complex scaffold
Related Protein HOMER1; DISC1; SLC9A3R1; ITSN1; SEPT2; SMARCD1; ARRB2; C9orf142; CNOT1; WWC2
Function protein heterodimerization activity
Related Protein BMP7A; BAXA; KCNH5; UNC13A; RAF1; H2-AA; TP53; HER11; HIF1A; INHA
Function protein kinase binding
Related Protein MSN; PDGFRB; ATG13; DNM2; CEP152; CACNB2; ITGB1BP1; CCNYL1; B4GALT1; ACVRL1
Function receptor binding
Related Protein NCK1; EFNA1; RSPO2; RND1; HNF4A; MLYCD; HAND2; GNPAT; IAPP; IL29
Function structural molecule activity
Related Protein EVPL; KRT34; COL15A1; CLDN1; FLG2; IFFO2; SPRR2A; NPHP1; COPG2; CLDN10B
Function syntaxin binding
Related Protein ABCA1; SYT3; NAPB; CPLX2L; NAPA; VPS54; TXLNBB; CPLX3A; CPLX4A; SYT9

Interacting Protein

CAV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAV1.
PTPN1; EGFR; TXNRD1; ID1

CAV1 Related Articles

Biswas, SK; Brako, L; et al. Massive formation of square array junctions dramatically alters cell shape but does not cause lens opacity in the cav1-KO mice. EXPERIMENTAL EYE RESEARCH 125:9-19(2014).
Paunescu, TG; Lu, HAJ; et al. Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F1783-F1795(2013).