CBR3
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Official Full Name
carbonyl reductase 3
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Overview
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols.The enzyme is classified as a monomeric NADPH-dependent oxidoreductase.CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. -
Synonyms
CBR3; carbonyl reductase 3; carbonyl reductase [NADPH] 3; SDR21C2; short chain dehydrogenase/reductase family 21C; member 2; Carbonyl reductase (NADPH) 3; Carbonyl reductase (NADPH) 3 EC 1.1.1.184; CBR 3; CBR3_HUMAN; EC 1.1.1.184; hCBR3; NADPH dependent carbonyl reductase 3; NADPH-dependent carbonyl reductase 3; Short chain dehydrogenase/reductase family 21C member 2; OTTHUMP00000109012; short chain dehydrogenase/reductase family 21C, member 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CBR3 involved in several pathways and played different roles in them. We selected most pathways CBR3 participated on our site, such as Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | PLA2G4AA;CYP4F22;PLA2G12A;CYP1A1;ALOX5A;CYP2C37;CYP4A14;PTGESL;PLA2G16 |
| Metabolism of xenobiotics by cytochrome P | UGT1A6;UGT1A9;CBR1L;UGT2A3;GSTT1;GSTM6;GSTM1;GSTM5;CBR3 |
| Metabolic pathways | ADC;POLR1E;AGPAT4;P4HA3;GAPDH;PLCG2;MTHFR;IMPDH2;Atp5k |
CBR3 has several biochemical functions, for example, 3-keto sterol reductase activity, NADPH binding, carbonyl reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CBR3 itself. We selected most functions CBR3 had, and list some proteins which have the same functions with CBR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-keto sterol reductase activity | DHRS4;CBR3;HSD17B7 |
| NADPH binding | DHFR;KCNAB1;MTRR;QDPR;TP53I3;DECR1;CRYZ;CBR4;CBR3 |
| carbonyl reductase (NADPH) activity | DHRS2;DHRS4;CBR3;CBR1;CBR2 |
CBR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBR3.
SGK1; USP3; ARIH2; RAB35; GABARAP; LDLR; CBR1; MKI67; RPS10; CCNL2; GABARAPL1
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