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CCND1

  • Official Full Name

    cyclin D1

  • Overview

    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
  • Synonyms

    CCND1; cyclin D1; BCL1; PRAD1; U21B31; D11S287E; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); parathyroid adenomatosis 1; BCL-1 oncogene; PRAD1 oncogene;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • flag
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • His|T7
  • Myc
  • MYC
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCND1-27756TH Recombinant Human CCND1 E.coli N/A
Human CCND1-221H Recombinant Human CCND1 protein, T7/His-tagged E.coli T7/His
Human CDK4/CCND1-633H Recombinant Human CDK4/CCND1, His-tagged Sf9 Insect Cell His
Human CCND1-27520TH Recombinant Human CCND1, His-tagged E.coli His
Human CCND1-1444H Recombinant Human Cyclin D1, GST-tagged E.coli GST
Human CCND1-171H Recombinant Human CCND1 protein, DDK-tagged Insect Cell DDK
Human CCND1-31773TH Recombinant Human Human CDK6, His-tagged His
Human IGLC1-14119H Recombinant Human IGLC1, His-tagged E.coli His 233a.a.
Human CCND1-23H Recombinant Human CCND1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CCND1-0658H Recombinant Human CCND1 Protein, GST-Tagged Wheat Germ GST
Human CCND1-354H Recombinant Human CCND1 protein, His/MBP-tagged E.coli His/MBP 9-138 aa
Human CCND1-24H Recombinant Human CCND1 protein, Flag-tagged Insect Cell flag
Human CCND1-355H Recombinant Human CCND1 protein, His/MBP-tagged E.coli His/MBP 167-295 aa
Human CCND1-7713HCL Recombinant Human CCND1 293 Cell Lysate HEK293 N/A
Human CCND1-0740H Recombinant Human CCND1 Protein (Leu65-Arg245), N-His tagged E.coli N-His Leu65-Arg245
Human CCND1-001HB Recombinant Human CCND1 Protein, His/Avi tagged, Biotinylated HEK293 His/Avi
Human CCND1-21H Recombinant Human CCND1 protein, His-tagged E. coli His 1-295aa
Human CCND1-1140H Recombinant Human CCND1 Protein (Lue65-Arg245), His tagged E.coli His Lue65-Arg245
Human CCND1-3824HFL Recombinant Full Length Human CCND1 protein, Flag-tagged Mamanlian cells Flag
Human CCND1-483H Recombinant Human CCND1 Protein, His-GST-tagged E. coli His/GST Met1~Ile295
Human CCND1-2967HF Recombinant Full Length Human CCND1 Protein, GST-tagged In Vitro Cell Free System GST 295 amino acids
Human CCND1-834H Recombinant Human CCND1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CCND1-3456H Recombinant Human CCND1 protein, His-tagged E.coli His 1-42 aa
Mouse CCND1-2988M Recombinant Mouse CCND1 Protein Mammalian Cell His
Mouse Ccnd1-2610M Recombinant Mouse Ccnd1 protein, His-tagged E.coli His Met31~Ile295
Mouse CCND1-1403M-B Recombinant Mouse CCND1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ccnd1-798M Recombinant Mouse Ccnd1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CCND1-1403M Recombinant Mouse CCND1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ccnd1-2611R Recombinant Rat Ccnd1 protein, His-tagged E.coli His Met1~Ile295 (Accession # P39948)
Rat CCND1-1219R Recombinant Rat CCND1 Protein Mammalian Cell His
Rat CCND1-877R-B Recombinant Rat CCND1 Protein Pre-coupled Magnetic Beads HEK293
Rat CCND1-877R Recombinant Rat CCND1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle CCND1-2608C Recombinant Cattle CCND1 protein, His & T7-tagged E.coli His/T7 Lys72~Ala272 (Accession # Q2KI22)
Rhesus Macaque CCND1-698R Recombinant Rhesus monkey CCND1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCND1-526R Recombinant Rhesus Macaque CCND1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CCND1-526R-B Recombinant Rhesus Macaque CCND1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CCND1-8654Z Recombinant Zebrafish CCND1 Mammalian Cell His
Chicken CCND1-6933C Recombinant Chicken CCND1 Mammalian Cell His
Chicken CCND1-2609C Recombinant Chicken CCND1 protein, His-tagged E.coli His Met1~Ile292 (Accession # P55169)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CCND1 Related Articles
  • CCND1 Related Signal Pathway

CCND1 involved in several pathways and played different roles in them. We selected most pathways CCND1 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCND1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayAKT3A;RAF1A;FOXO1A;CAT;AKT2L;G6PCA.1;GRB2;IRS2;SMAD4
Cell cycleDCTN1;CDC25C;RAD9B;BANF1;TMEM188;STIL;YWHAE1;CHEK1;MAU2
p signaling pathwayIGF1;BAX;RRM2;CCNE1;CASP3B;TRP53;CCNG2;SERPINB5;TP53AIP1
PIK-Akt signaling pathwayPDGFB;Il4ra;PRKAA2;IL7;PPP2R3A;ITGB8;ITGAV;ITGB4;BRCA1
AMPK signaling pathwayCREB3L3;PFKL;RHEB;PDPK1;CAMKK1;SCD;PFKFB2;HNF4A;AKT1
Wnt signaling pathwayPPP3R2;CTBP2A;LRP6;WNT11;PPP3CA;WNT4A;FZD8A;NLK;CUL1
Hippo signaling pathwaySMAD3;FBXW11;FRMD6;BMP8A;YWHAG;Fzd4;FZD10;SMAD4;MOB1A
Focal adhesionDIAPH1;VEGFB;CDC42L;SHC4;RAP1AB;MYL12A;ROCK2B;VEGFAB;ITGB4
Jak-STAT signaling pathwayPTPN11A;IL6ST;SOCS2;PIK3CD;IFNPHI1;PIK3R1;IL3RA;IL9;IFNA14
Prolactin signaling pathwayPRP2;FOXO3;STAT1;HRAS;NEK3;PIK3R2;SLC2A2;SHC2;SOCS7
Thyroid hormone signaling pathwayMED12L;PIK3CD;RHEB;RXRG;ATP2A2;RAF1;AKT2;THRA;MDM2
Oxytocin signaling pathwayPLA2G4A;CACNG7;PIK3R1;PLCB4;RYR3;TRPM2;CACNG4;PRKAB2;CALM3
Hepatitis BRB1;TIRAP;IFNA16;TICAM2;STAT1;STAT4;MAP2K2;FAS;NFKBIA
MeaslesTLR2;IFNAR2;TLR9;STAT5B;CBLB;AKT1;IFNA1;Fasl;AKT2
HTLV-I infectionCREM;DLG1;TP53INP1;WNT5B;FOS;ANAPC11;PDGFRB;MAP2K4;WNT4
Pathways in cancerF2RL3;PIK3CG;HIF1A;WNT2;SLC2A1;Fgf15;AXIN2;SMAD3;GNG10
Viral carcinogenesisACTN3;TBPL1;HIST1H2BB;TBPL2;HIST1H4M;YWHAH;HIST2H2BE;HIST1H4H;H2BFWT
Proteoglycans in cancerFN1;WNT2;HPSE2;ANK1;RPS6;WNT9B;FZD10;FZD9;IGF2
MicroRNAs in cancerTHBS1;TGFB2;DNMT3A;BCL2L2;RPTOR;IRS1;CD44;MMP9;SPRY2
Colorectal cancerPIK3R1;CYCS;CCND1;RALGDS;SMAD2;MAP2K1;FOS;TCF7L2;MAPK1
Pancreatic cancerRAC1;MAP2K1;SMAD3;CCND1;CASP9;PIK3R2;PIK3CD;PIK3R1;RAF1
Endometrial cancerMAPK3;APC;PIK3R5;TP53;MAP2K2;HRAS;PIK3CB;AKT1;APC2
GliomaCAMK2G;PDGFRA;BRAF;CAMK2A;ARAF;GRB2;PTEN;AKT2;CALM2
Prostate cancerNKX3;RELA;MDM2;PDGFC;NOXA1;SPRY1;HSP90AB1;MAPK1;BCL2
Thyroid cancerRET;RXRG;NCOA4;MAP2K1;MAPK3;RXRA;LEF1;KRAS;CDH1
MelanomaFGF3;FGF9;FGF5;TRP53;PIK3R2;PIK3CG;CCND1;BAD;RAF1
Bladder cancerMDM2;THBS1;MAPK1;TP53;VEGFA;EGF;BRAF;DAPK2;E2F3
Chronic myeloid leukemiaIKBKB;MAPK3;RB1;PIK3CB;HDAC2;IKBKG;RELA;GAB2;TGFBR1
Acute myeloid leukemiaMAP2K1;PPARD;SOS1;PIK3R3;RPS6KB2;AKT2;EIF4EBP1;RAF1;STAT5A
Small cell lung cancerPIAS2;RELA;ITGAV;CYCS;CCNE1;TRAF5;ITGA6;MAX;BIRC8
Non-small cell lung cancerRB1;FHIT;RXRA;RARB;RAF1;FOXO3;TGFA;TP53;PIK3CA
Viral myocarditisEIF4G3;HLA-DPB1;SGCB;ICAM1;HLA-F;ABL2;SGCA;HLA-DPA1;LAMA2

CCND1 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCND1 itself. We selected most functions CCND1 had, and list some proteins which have the same functions with CCND1. You can find most of the proteins on our site.

Function Related Protein
cyclin-dependent protein serine/threonine kinase regulator activityCCNL1A;CCNY;CCNL2;CCNL1B;CCNT2A;CCNC;CKS2;CCNT1;CCND1
enzyme bindingPLAUR;GSTM4;PARP1;EHHADH;HIST1H2AN;CCDC99;ACAT1;P4HB;EIF4E
histone deacetylase bindingYWHAE;HOXA10;ZNHIT1;NCOR1;HDAC3;MECP2;SP1;SRF;RFXANK
proline-rich region bindingWBP4;CSK;ABI2;GAREM;FAM59A;BAIAP2L1;APBB1;ABL1;CCND1
protein bindingCSPG5;POP4;HOOK3;BSCL2;TLX2;VIP;ORC4L;EPS15;DFFA
protein complex bindingARRB2;LCK;WASF2;BCAP31;CDK4;KIF11;PEX1;ATG101;EPCAM
protein kinase activityTGFBR1A;TNIKA;SNRKB;PRKCZ;MAP4K6;CDKL3;TLK1A;SGK3;MAP3K4
protein kinase bindingPDGFRB;RPS6;FBXO7;PLK1S1;DNAJC3;LIPE;TPCN2;LSM2;LIMS1
transcription corepressor activityNFKBIL2;HIF3A;ATF5;RARA;NRIP1;YWHAB;HOMEZ;APEX1;SIRT1
transcription factor bindingSOST;HMGA1-RS1;RELA;E2F4;UBE2I;NBN;SOX8;DIP2BA;CCND1

CCND1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCND1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCND1.

CDK4; CDKN1A

Tajiri, R; Ooi, A; et al. Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent probe amplification and fluorescence in situ hybridization. HUMAN PATHOLOGY 45:725-734(2014).
Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
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