CCT4
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Official Full Name
chaperonin containing TCP1, subunit 4 (delta)
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Overview
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2;back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly;translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded;intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM;191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 (PubMed 9819444)). -
Synonyms
CCT4; chaperonin containing TCP1, subunit 4 (delta); T-complex protein 1 subunit delta; Cctd; TCP-1-delta; stimulator of TAR RNA-binding; chaperonin containing t-complex polypeptide 1, delta subunit; SRB; CCT-DELTA; MGC126164; MGC126165;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CCT4 involved in several pathways and played different roles in them. We selected most pathways CCT4 participated on our site, such as Assembly of the primary cilium, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | DYNLL2B;CETN2;CEP78;RHOL;TCTEX1D1;LZTFL1;CEP57;CKAP5;TSGA14 |
| Association of TriC/CCT with target proteins during biosynthesis | FBXW5;CCT3;CCT7;TCP1;NOP56;KIFC3;CCT4;FBXW4;FKBP9 |
| BBSome-mediated cargo-targeting to cilium | BBS5;BBS10;TTC8;PROL1;RAB3IP;MKKS;TCP1;CCT3;CCT4 |
| Cargo trafficking to the periciliary membrane | EXOC5;CCT5;SETD6;UNC119B;ARF4;TTC8;ARL13B;NPHP3;RAB3IP |
| Chaperonin-mediated protein folding | PFDN1;FBXL5;FBXW2;PFDN6;PFDN5;CCT3;TUBB4A;CCT6A;CCT7 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | CCT3;CCT6A;PFDN6;PFDN4;TUBB4A;CCT5;TCP1;CCT7;VBP1 |
| Folding of actin by CCT/TriC | CCT7;CCT4;CCT3;CCT8;CCT5;CCT2;CCT6A;TCP1 |
| Formation of tubulin folding intermediates by CCT/TriC | CCT7;TUBA3D;CCT5;TUBB4A;CCT2;TUBB4B;CCT8;CCT3;CCT4 |
CCT4 has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT4 itself. We selected most functions CCT4 had, and list some proteins which have the same functions with CCT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCA6;MAPKAPK2B;SMYHC3;ACVR2B;STK32C;EPHB1;ITK;EIF4A1;PHKG2 |
| poly(A) RNA binding | MRPL3;ATXN2;DDX55;NOL10;GLRX3;LSM6;SERBP1;RPS24;ZCCHC6 |
| protein binding | SERTAD3;TNNI3K;ASIC2;NKAP;CUTC;KAT2A;KLHL22;ZNF317;CDKN1B |
| unfolded protein binding | SIL1;CALR3;ERO1LB;DNAJA1;HSPA1A;SCG5;PFDN1;CCT6B;CRYAB |
CCT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT4.
PPP4C; PPP2CB; PPP2CA; STRN3; ILK; OLR1; STRN
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