CD3E
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Official Full Name
CD3e molecule, epsilon (CD3-TCR complex)
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Overview
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. -
Synonyms
CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell antigen receptor complex, epsilon subunit o; T3E; TCRE; IMD18; T-cell antigen receptor complex,;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chromatography Reagents
- Protein Pre-coupled Magnetic Beads
- Canine
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Cynomolgus
- Cynomolgus monkey
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Monkey
- Mouse
- Ovis aries (Sheep)
- Rat
- Rhesus
- Rhesus Macaque
- Western lowland gorilla
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293F
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- Fc
- Avi
- hFc
- His
- Twin
- Strep
- DDK|His
- Fc\Avi
- Flag
- mFc
- Flag|Fc|His
- FLAG
- GST
- His (Fc)
- flag
- His|Avi
- His|Fc
- His|Fc|Flag
- His|Flag
- His|human|IgG1|Fc
- human|IgG1|Fc
- Human|IgG1|Fc
- Llama|IgG2b|Fc
- mFC
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- CD3E Related Articles
- CD3E Related Gene Family
- CD3E Related Research Area
CD3E involved in several pathways and played different roles in them. We selected most pathways CD3E participated on our site, such as Hematopoietic cell lineage, T cell receptor signaling pathway, Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD3E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Hematopoietic cell lineage | CD8A;IL6R;CD14;Kitl;CD9;GM-CSF;CD1E;IL3RA;CD1D |
T cell receptor signaling pathway | LCP2;MAPK9;CD8B1;NFATC3;MAP3K14;PPP3R2;NFATC2;NCK2;IKBKG |
Chagas disease (American trypanosomiasis) | PPP2R1B;CASP8;CD3G;RELA;C1QC;IFNGR1;TNF;MAPK1;TGFBR1 |
Measles | FYN;IFNA17;TNFRSF10B;BBC3;MX1;OAS2;RAB9A;IFNA13;HSPA2 |
HTLV-I infection | IL2RB;ANAPC7;TBP;MAP2K4;PTTG2;TGFB2;VDAC1;IL6;TCF3 |
Primary i | CD8B1;TAP1;RAG2;TAP2;RFXANK;ORAI1;CD8B;AIRE;IGLL1 |
nodeficiency | IL2RG;IKBKG;CD19;RFXAP;CD8A;DCLRE1C;IGLL1;CD40;RAG1 |
CD3E has several biochemical functions, for example, SH3 domain binding, T cell receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD3E itself. We selected most functions CD3E had, and list some proteins which have the same functions with CD3E. You can find most of the proteins on our site.
Function | Related Protein |
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SH3 domain binding | ARHGAP31;CIT;CBL;RAD9;PDE4D;SH3BP5LA;EFS;USP8;INPPL1B |
T cell receptor binding | FYN;EPS8L1;CD3G;H2-Q10;HLA-A;CD1d1;DOCK2;CD3E |
protein binding | TFR2;NAPA;HEATR5B;CAPRIN2;TRIP4;TSEN54;ATG9A;ATG7;WLS |
protein heterodimerization activity | KCNH1;TBX15;HIST1H2BF;BNIP3L;DRAP1;MEIS1;TLX1;TPD52L2;THRA |
protein kinase binding | PRC1;PRKAG2;NPM1;PLK1;CCNB1;SLC12A4;PTPRR;TPCN2;CD36 |
receptor signaling complex scaffold activity | ROPN1B;AXIN1;CARD10;NCK2;GRIP2A;DEDD2;SHANK1;MMS19;NUP62 |
receptor signaling protein activity | ADCYAP1;DOK5;FLRT3;FCGR1A;cgr2b;IL1RL1;NGF;TIAM2;RGS14 |
transmembrane signaling receptor activity | TLR2-1;IL4R.1;DNER;TLR10;CD97;GPR98;IL1R1;NRXN3;GPR126 |
CD3E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD3E here. Most of them are supplied by our site. Hope this information will be useful for your research of CD3E.
EPS8L1; NCK1; SYK; ZAP70
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, CD3E levels and T-cell function can be monitored to evaluate the response to cancer immunotherapies like checkpoint inhibitors.
There are currently no approved therapies that directly target CD3E, but it is a target for research in developing immunotherapies and cancer treatments.
There may be ongoing clinical trials using CD3E-targeted therapies in the context of cancer and autoimmune diseases. It's important to check clinical trial databases for specific studies.
Yes, monitoring CD3E levels in HIV-infected individuals can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy.
CD3E can be used in research to study T-cell responses in allergic conditions, helping to better understand and diagnose allergies.
Customer Reviews (3)
Write a reviewManufacturers with the capacity for bulk production can offer CD3E protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.
bulk production often leads to economies of scale, making the CD3E protein more cost-effective for research budgets.
Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using CD3E protein.
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