CD48
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Official Full Name
CD48 CD48 molecule
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Overview
CD48 is a glycosylphosphatidylinositol-anchored protein belonging to the CD2 subfamily. It is expressed mainly on hematopoietic cells and exists in both membrane-associated and soluble forms. It is a low-affinity ligand for CD2 and is implicated as an important costimulatory molecule in lymphocyte activation. Indeed, CD48 has been described as facilitating cell adhesion, innate responses to bacterial infection, and graft rejection. In addition, CD48 is a high-affinity ligand for 2B4. CD482B4 interactions can modulate T cell, B cell, and natural killer (NK) cell functions and cross-talk.The absence of functional 2B4 CD48 interactions impairs NK cell cytotoxic response and IFN-release on tumor target exposure. Furthermore, activated NK cells significantly increase the CD3-dependent proliferation of CD8+ and CD4+ T cells by a 2B4CD48-dependent mechanism. -
Synonyms
CD48; CD48 molecule; BCM1, CD48 antigen (B cell membrane protein) , CD48 molecule; CD48 antigen; BLAST; hCD48; mCD48; SLAMF2; TCT.1; BCM1 surface antigen; leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen (B-cell membrane protein); BCM1; BLAST1; MEM-102;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- CHO
- CHO cells
- E. coli
- E.coli
- HEK293
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Rabbit
- Wheat Germ
- Yeast
- C
- Fc
- hFc
- His
- Avi
- Fc|His
- His(C
- ter)
- GST
- His (Fc)
- His|T7
- human|IgG1|Fc
- Mouse|IgG2a|Fc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CD48 Related Articles
- CD48 Related Gene Family
- CD48 Related Research Area
CD48 involved in several pathways and played different roles in them. We selected most pathways CD48 participated on our site, such as Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD48 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Natural killer cell mediated cytotoxicity | IFNA5;TYROBP;IFNGR1;MICA;ULBP2;RAET1D;KIR2DS2;HLA-B;RAC3 |
CD48 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD48 itself. We selected most functions CD48 had, and list some proteins which have the same functions with CD48. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | P4HA2;TRIM43;ARL11;NLRP2;PAN2;LNPEP;MAL;CAST;KRT18 |
CD48 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD48 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD48.
CD244; EEF1D; yapA; BXDC2
- Q&As
- Reviews
Q&As (6)
Ask a questionThere is currently no treatment that directly regulates CD48 protein expression levels. However, by regulating the function of the immune system, the expression level of CD48 protein can be indirectly affected to treat some diseases.
Expression level of CD48 protein is associated with the prognosis of certain tumors. In some cancers, high levels of CD48 protein expression may predict a poor prognosis.
CD48 protein is an important molecule in the immune system that is involved in the activation and differentiation of lymphocytes and phagocytes, as well as inflammation and tissue repair. Its expression levels may affect the function of the immune system.
Studies have shown that the expression level of CD48 protein may affect the effectiveness of vaccination. In some cases, high levels of CD48 protein expression may suppress the immune response, thus affecting the effectiveness of vaccination.
Yes, the CD48 protein can be used as a biomarker for some tumors. Studies have shown that in some cancers, high levels of CD48 protein expression may predict tumor growth and metastasis.
Studies have shown that the expression level of CD48 protein may be associated with the occurrence and progression of certain diseases. For example, in some cancers, the expression level of the CD48 protein may affect the growth and metastasis of the tumor.
Customer Reviews (3)
Write a reviewThe anti-interference ability in Western blot is very strong, which can effectively resist the influence of endogenous interference factors.
High safety, high expression level, ideal for laboratory and practical applications.
Low preparation cost, high cost performance, saving funds, very suitable for our research.
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