CDH13
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Official Full Name
cadherin 13
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Overview
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011] -
Synonyms
CDH13; cadherin 13; CDHH; P105; cadherin-13; T-cad; T-cadherin; heart cadherin; H-cadherin (heart); cadherin 13, H-cadherin (heart);
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- hFc
- His (Fc)
- Avi
- His|GST
- N/A
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- CDH13 Related Articles
- CDH13 Related Research Area
CDH13 involved in several pathways and played different roles in them. We selected most pathways CDH13 participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adherens junctions interactions | CDH13;CDH3;ANG;CTNNB2;CDH9;CDH4;CTNND1;CDH8;CDH18 |
Cell junction organization | FERMT2;PVRL1A;CDH6;INADL;CDH7;ANG;ITGB1B.1;F11R.2;PLECA |
Cell-Cell communication | F11R.2;CLDN16;CDH7;DSCAML1;CLDN20;FBLIM1;SPTBN1;PLEC;COL17A1A |
Cell-cell junction organization | ANG;CDH6;CLDN20;CDH13;F11R.2;CDH12A;CDH5;CLDN23;CDH11 |
CDH13 has several biochemical functions, for example, adiponectin binding, cadherin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH13 itself. We selected most functions CDH13 had, and list some proteins which have the same functions with CDH13. You can find most of the proteins on our site.
Function | Related Protein |
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adiponectin binding | ADIPOR2;ADIPOR1;CDH13 |
cadherin binding | TBC1D2;PSEN1;JUPA;CTNNAL1;CD46;CDH13;NDRG1;PROM1;CTNNB1 |
calcium ion binding | MYL6;SPTAN1;S100T;SLC25A13;DOC2D;SYTL1;CUBN;DSC2L;MYL4 |
lipoprotein particle binding | APOE;MAPT;GPIHBP1;CDH13 |
low-density lipoprotein particle binding | THBS1;ANKRA2;LIPC;SCARF1;CDH13;COLEC12;LDLR;SCARB1;SORL1 |
protein homodimerization activity | PVALB;BAXB;PDXK;OLIG2;NR4A3;SLC16A1;E2F8;TCF3B;ODC1 |
CDH13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH13 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH13.
AURKA; HMMR; CHEK2; PTPN1; CCND1; RAD51; CASP8; MAPK6
- Q&As
- Reviews
Q&As (6)
Ask a questionFuture research on CDH13 may involve more in-depth research on molecular mechanisms, new drug development, and targeted therapeutic strategies based on CDH13.
There are multiple interactions between CDH13 and other molecules and drugs, including growth factors, cytokines, and drugs.
It is unclear whether there is a population difference in the treatment of CDH13. However, due to factors such as individual differences and genetic polymorphisms, different populations may respond differently to treatment.
At present, the expression level of CDH13 as a biomarker for disease diagnosis or prognosis is not sufficient, and further validation is needed.
Studies have shown that CDH13 is associated with the occurrence and progression of cardiovascular disease, and it can affect the production of blood vessels, the development of heart cells, and heart function.
Recent studies have shown that CDH13 is expressed abnormally in some tumors, which may be related to the occurrence and progression of tumors.
Customer Reviews (3)
Write a reviewIt is highly active, and a small amount can play a role, saving reagents.
CDH13 is easy to store and can be stored for a long time, which is very suitable for our research needs.
No significant differences were found between different batches, and the batch-to-batch reproducibility was good.
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