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CDH13

  • Official Full Name

    cadherin 13

  • Overview

    This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
  • Synonyms

    CDH13; cadherin 13; CDHH; P105; cadherin-13; T-cad; T-cadherin; heart cadherin; H-cadherin (heart); cadherin 13, H-cadherin (heart);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDH13-0975H Recombinant Human CDH13 Protein, GST-Tagged Wheat Germ GST
Human CDH13-11031H Recombinant Human CDH13, GST-tagged E.coli GST C-term-350a.a.
Human CDH13-31H Recombinant Human CDH13 protein, T7/His-tagged E.coli T7/His
Human CDH13-3137HF Recombinant Full Length Human CDH13 Protein, GST-tagged In Vitro Cell Free System GST 713 amino acids
Human CDH13-2961H Recombinant Human CDH13 protein, His-tagged E.coli His 364-713 aa
Human CDH13-3864H Recombinant Human CDH13 Protein (Glu23-Ala692), C-His tagged Mammalian cells C-His Glu23-Ala692
Mouse Cdh13-721M Active Recombinant Mouse Cdh13 Protein, His-tagged Mammalian cells His Met1-Gly693
Mouse CDH13-3166M Recombinant Mouse CDH13 Protein Mammalian Cell His
Mouse Cdh13-1947M Recombinant Mouse Cdh13 protein, His & GST-tagged E.coli His/GST Tyr478-Asn690 (Accession # Q9WTR5)
Mouse Cdh13-992M Recombinant Mouse Cdh13 Protein, His-tagged HEK293 His
Mouse Cdh13-1505M Recombinant Mouse Cdh13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cdh13-1505M-B Recombinant Mouse Cdh13 Protein Pre-coupled Magnetic Beads HEK293
Rat Cdh13-991M Recombinant Rat Cdh13 protein, hFc-tagged HEK293 hFc Met1-Ala692
Rat Cdh13-26R Recombinant Rat Cdh13, His tagged Human Cell His
Rat Cdh13-27R Recombinant Rat Cdh13, LEVLFQ tagged Human Cell His
Rat Cdh13-25R Recombinant Rat Cdh13, Fc tagged Human Cell His
Rat Cdh13-1948R Recombinant Rat Cdh13 protein, His & GST-tagged E.coli His/GST Tyr478-Asn690 (Accession # Q8R490)
Rat CDH13-802RCL Recombinant Rat CDH13 cell lysate Human Cell N/A
Rat CDH13-1269R Recombinant Rat CDH13 protein(Met1-Ala692) HEK293 N/A Met1-Ala692
Rat Cdh13-148R Recombinant Rat Cdh13 Protein, hFc-tagged HEK293 hFc Met1-Ala692
Rhesus Macaque CDH13-775R Recombinant Rhesus monkey CDH13 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CDH13-601R-B Recombinant Rhesus Macaque CDH13 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDH13-601R Recombinant Rhesus Macaque CDH13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CDH13-1156C Recombinant Chicken CDH13 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDH13 Related Articles
  • CDH13 Related Research Area

CDH13 involved in several pathways and played different roles in them. We selected most pathways CDH13 participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adherens junctions interactionsCDH13;CDH3;ANG;CTNNB2;CDH9;CDH4;CTNND1;CDH8;CDH18
Cell junction organizationFERMT2;PVRL1A;CDH6;INADL;CDH7;ANG;ITGB1B.1;F11R.2;PLECA
Cell-Cell communicationF11R.2;CLDN16;CDH7;DSCAML1;CLDN20;FBLIM1;SPTBN1;PLEC;COL17A1A
Cell-cell junction organizationANG;CDH6;CLDN20;CDH13;F11R.2;CDH12A;CDH5;CLDN23;CDH11

CDH13 has several biochemical functions, for example, adiponectin binding, cadherin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH13 itself. We selected most functions CDH13 had, and list some proteins which have the same functions with CDH13. You can find most of the proteins on our site.

Function Related Protein
adiponectin bindingADIPOR2;ADIPOR1;CDH13
cadherin bindingTBC1D2;PSEN1;JUPA;CTNNAL1;CD46;CDH13;NDRG1;PROM1;CTNNB1
calcium ion bindingMYL6;SPTAN1;S100T;SLC25A13;DOC2D;SYTL1;CUBN;DSC2L;MYL4
lipoprotein particle bindingAPOE;MAPT;GPIHBP1;CDH13
low-density lipoprotein particle bindingTHBS1;ANKRA2;LIPC;SCARF1;CDH13;COLEC12;LDLR;SCARB1;SORL1
protein homodimerization activityPVALB;BAXB;PDXK;OLIG2;NR4A3;SLC16A1;E2F8;TCF3B;ODC1

CDH13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH13 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH13.

AURKA; HMMR; CHEK2; PTPN1; CCND1; RAD51; CASP8; MAPK6

Dai, J; Li, L; et al. Parallel detection and quantitative analysis of specific binding of proteins by oblique-incidence reflectivity difference technique in label-free format. SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY 57:2039-2042(2014).
Bosserhoff, AK; Ellmann, L; et al. Loss of T-Cadherin (CDH-13) Regulates AKT Signaling and Desensitizes Cells to Apoptosis in Melanoma. MOLECULAR CARCINOGENESIS 53:635-647(2014).
  • Q&As
  • Reviews

Q&As (6)

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What are possible future directions for CDH13 research? 11/27/2022

Future research on CDH13 may involve more in-depth research on molecular mechanisms, new drug development, and targeted therapeutic strategies based on CDH13.

How about the interactions between CDH13 and other molecules or drugs? 10/12/2022

There are multiple interactions between CDH13 and other molecules and drugs, including growth factors, cytokines, and drugs.

Are there population differences in CDH13 treatment? 11/26/2021

It is unclear whether there is a population difference in the treatment of CDH13. However, due to factors such as individual differences and genetic polymorphisms, different populations may respond differently to treatment.

Can the expression level of CDH13 be used as a biomarker for disease diagnosis or prognosis? 11/03/2021

At present, the expression level of CDH13 as a biomarker for disease diagnosis or prognosis is not sufficient, and further validation is needed.

What is the role of CDH13 in cardiovascular disease? 02/26/2020

Studies have shown that CDH13 is associated with the occurrence and progression of cardiovascular disease, and it can affect the production of blood vessels, the development of heart cells, and heart function.

Is CDH13 related to the occurrence and development of tumors? 12/05/2019

Recent studies have shown that CDH13 is expressed abnormally in some tumors, which may be related to the occurrence and progression of tumors.

Customer Reviews (3)

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Reviews
02/17/2023

    It is highly active, and a small amount can play a role, saving reagents.

    07/12/2022

      CDH13 is easy to store and can be stored for a long time, which is very suitable for our research needs.

      09/14/2021

        No significant differences were found between different batches, and the batch-to-batch reproducibility was good.

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