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CELSR3

Official Full Name

cadherin, EGF LAG seven-pass G-type receptor 3
Overview

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
Synonyms

CELSR3; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); cadherin EGF LAG seven pass G type receptor 3, flamingo (Drosophila) homolog , EGFL1; cadherin EGF LAG seven-pass G-type receptor 3; CDHF11; FMI1; HFMI1; MEGF2; anchor;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CELSR3-1110H	Recombinant Human CELSR3 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CELSR3-474H	Recombinant Human CELSR3 Protein, His-tagged	E.coli	His	Ser1181~Cys1421	$298 / 10ug
Mouse	CELSR3-3279M	Recombinant Mouse CELSR3 Protein	Mammalian Cell	His		Inquiry
Mouse	CELSR3-1573M-B	Recombinant Mouse CELSR3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	CELSR3-1573M	Recombinant Mouse CELSR3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Celsr3-475M	Recombinant Mouse Celsr3 Protein, His-tagged	E.coli	His	Val942~Ser1175	$298 / 10ug
Rat	CELSR3-1332R	Recombinant Rat CELSR3 Protein	Mammalian Cell	His		Inquiry
Rat	CELSR3-990R	Recombinant Rat CELSR3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CELSR3-990R-B	Recombinant Rat CELSR3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

CELSR3 involved in several pathways and played different roles in them. We selected most pathways CELSR3 participated on our site, such as GPCRs, Other, Non-odorant GPCRs, which may be useful for your reference. Also, other proteins which involved in the same pathway with CELSR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
GPCRs, Other	EMR2;S1PR1;RRH;VMN1R43;OR10A5;GPR61;CELSR1;VMN1R50;GPR162
Non-odorant GPCRs	EMR4;OPN3;CELSR1;GPR15;CELSR3;GPR132;O3far1;RRH;BAI2

CELSR3 has several biochemical functions, for example, G-protein coupled receptor activity, calcium ion binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CELSR3 itself. We selected most functions CELSR3 had, and list some proteins which have the same functions with CELSR3. You can find most of the proteins on our site.

Function	Related Protein
G-protein coupled receptor activity	CXCR5;LPAR4;OLFR507;PTH1RA;OLFCS2;OR4C13;OLFR181;HTR1E;OR115-6
calcium ion binding	PCDH10B;F9A;CLSTN1;SLC24A4A;CRELD1;PCDH2G5;MMP14B;MMP28;SMOC1
signal transducer activity	AGTR1B;PLCH2;PTGER4A;GPR31B;MRGPRA8;SLC35B2;TAAR14G;PLCL1;MUL1
transmembrane signaling receptor activity	ANTXR1;GPR126;ADCYAP1R1A;CD27;EBP;FZD3A;HIST2H3C2;ENG;KIR2DL4

CELSR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CELSR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CELSR3.

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