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CFLAR

  • Official Full Name

    CASP8 and FADD-like apoptosis regulator

  • Overview

    The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
  • Synonyms

    CFLAR; CASP8 and FADD-like apoptosis regulator; CASH; FLIP; MRIT; CLARP; FLAME; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1; usurpin beta; caspase homolog; inhibitor of FLICE; caspase-eight-related protein; MACH-related inducer of toxicity; FADD-like anti-apoptotic molecule; FADD-like antiapoptotic molecule 1; caspase-related inducer of apoptosis; cellular FLICE-like inhibitory protein; caspase-like apoptosis regulatory protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His|T7
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CFLAR-3638H Recombinant Human CFLAR Human N/A
Human CFLAR-28415TH Recombinant Human CFLAR E.coli N/A 480 amino acids
Human CFLAR-1176H Recombinant Human CFLAR Protein, GST-Tagged Wheat Germ GST
Human CFLAR-7553HCL Recombinant Human CFLAR 293 Cell Lysate HEK293 N/A
Human CFLAR-3298HF Recombinant Full Length Human CFLAR Protein, GST-tagged In Vitro Cell Free System GST 480 amino acids
Human CFLAR-2722H Recombinant Human CFLAR Protein (Asp31-Asn184), N-His tagged E.coli N-His Asp31-Asn184
Mouse Cflar-1831M Recombinant Mouse Cflar protein, His & T7-tagged E.coli His/T7 Asn210~Gly460 (Accession # O35732)
Mouse Cflar-882M Recombinant Mouse Cflar Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Cflar-1832R Recombinant Rat Cflar protein, His & T7-tagged E.coli His/T7 Arg43~Tyr281 (Accession # C0H5Y5)
Chicken CFLAR-4496C Recombinant Chicken CFLAR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CFLAR involved in several pathways and played different roles in them. We selected most pathways CFLAR participated on our site, such as NF-kappa B signaling pathway, Apoptosis, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFLAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayTNFSF11;TRAF1;PLCG2;LY96;LTB;IRAK1;ZAP70;TRAF6;IL1B
ApoptosisCYCSB;APAF1;PRKAR2A;RELA;GZMC;IRF2;GAS2;TRAF2;PTBP3
TNF signaling pathwayMMP14;PIK3CD;MAP2K4;ATF4;CREB5;SOCS3;PIK3CG;CASP7;CX3CL1
Chagas disease (American trypanosomiasis)CCL3L3;IKBKG;PIK3CG;PIK3R2;FAS;CXCL8;C3;PIK3R1;FASLG

CFLAR has several biochemical functions, for example, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, death effector domain binding, death receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFLAR itself. We selected most functions CFLAR had, and list some proteins which have the same functions with CFLAR. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase activity involved in apoptotic signaling pathwayCASP2;CASP8;CASP14;CASP9;CFLARA;CASP10;CFLAR;CASP8L1
death effector domain bindingCASP8L1;NOL3;CFLAR;FADD;CASP8;CASP10;CFLARA
death receptor bindingFEM1B;TMBIM1;PIDD1;Casp3;FADD;TNFSF15;RIPK1;NOL3;FASLG
enzyme activator activityARL1;RAB3GAP2;MMP16;GTF3C4;SEC14L2;GLC8;DCP1B;GMFB;PPP1R12B
protease bindingCRADD;KIT;CCDC71L;RYR1;TIMP2B;HSPA6;THAP5;SERPINB4;CD28
protein bindingHIST1H2BI;HIST1H2AM;TERT;PPP2R5C;SOCS1;KLHDC3;N4BP2L2;MED12;EGR1
protein complex bindingCDKN1B;ULK1;PPP2R2A;RAN;CCNE1;CEBPA;TG;TELO2;NDUFA8

CFLAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFLAR here. Most of them are supplied by our site. Hope this information will be useful for your research of CFLAR.

CASP10; CASP8; TRAF1; TNFSF10; b4dyc6_human; EIF3F; DOK2

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