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CHN1

  • Official Full Name

    chimerin (chimaerin) 1

  • Overview

    This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duanes retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Synonyms

    CHN1; chimerin (chimaerin) 1; CHN, Duane retraction syndrome 2 , DURS2; N-chimaerin; ARHGAP2; Chimerin 1 (GTPase activating protein; rho; 2); n chimerin; RhoGAP2; A-chimaerin; Alpha-chimerin; CHIN_HUMAN; CHN; N chimaerin; N-chimerin; NC; Rho GTPase-activating protein 2; a2-chimaerin; OTTHUMP00000205333; OTTHUMP00000205334; OTTHUMP00000205335; OTTHUMP00000205339; OTTHUMP00000205340; OTTHUMP00000205342; DURS2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHN1-11192H Recombinant Human CHN1, GST-tagged E.coli GST N-term-350a.a.
Human CHN1-1256H Recombinant Human CHN1 Protein, GST-Tagged Wheat Germ GST
Human CHN1-240H Recombinant Human CHN1, Gly&Pro tagged Insect Cell Fc
Human CHN1-241H Recombinant Human CHN1, His-GST tagged Insect Cell Fc
Human CHN1-001HCL Recombinant Human CHN1 cell lysate Insect Cell N/A
Human CHN1-002HCL Recombinant Human CHN1 cell lysate Insect Cell N/A
Human CHN1-0255H Recombinant Human CHN1 protein, His&GST-tagged Insect Cells His/GST Ala2-Phe459
Human CHN1-3230H Recombinant Human CHN1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CHN1-2197H Recombinant Human CHN1 protein Insect Cells N/A Ala2-Phe459
Human CHN1-3758H Recombinant Human CHN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CHN1-3093H Recombinant Human CHN1 protein, His-tagged E.coli His 145-207 aa
Human CHN1-3211HF Recombinant Full Length Human CHN1 Protein, GST-tagged In Vitro Cell Free System GST 459 amino acids
Mouse Chn1-383M Recombinant Mouse Chn1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat CHN1-1378R Recombinant Rat CHN1 Protein Mammalian Cell His
Rat CHN1-1036R-B Recombinant Rat CHN1 Protein Pre-coupled Magnetic Beads HEK293
Rat CHN1-1036R Recombinant Rat CHN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CHN1-12244Z Recombinant Zebrafish CHN1 Mammalian Cell His
Chicken CHN1-2163C Recombinant Chicken CHN1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHN1 Related Articles

CHN1 involved in several pathways and played different roles in them. We selected most pathways CHN1 participated on our site, such as Regulation of RAC1 activity, Rho GTPase cycle, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Regulation of RAC1 activityARHGEF25;CHN1;DEF6;RALBP1;SPATA13;EPS8;PREX2;ARHGAP1;RAP1GDS1
Rho GTPase cycleMCF2L;CHN1;RHOT2;TAGAPB;ARHGAP6;DEPDC1B;ARAP2;ARHGAP17A;FGD4A
Signal TransductionSAGB;INSL3;RGS14;CUL5A;SEPT7;FABP11B;HEYL;IFT172;DHRS3A
Signaling by Rho GTPasesRHOT1A;MKL1;TAX1BP3;ARHGAP17;FGD2;NOXO1;GDI2;TAGAP1;ARHGAP29B

CHN1 has several biochemical functions, for example, GTPase activator activity, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHN1 itself. We selected most functions CHN1 had, and list some proteins which have the same functions with CHN1. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityARHGAP6;ARHGAP29B;SH3BP1;PLEKHG6;ARHGAP23;SRGAP2;GIT2B;TBC1D17;ACAP3B
SH3/SH2 adaptor activityCD28;STAM;SRC;GAB1;KHDRBS1;GRB7;SH2B2;SH3BGRL;LASP1
ephrin receptor bindingNTRK1;EFNB2A;EPHA4;PIK3CG;CHN1;EFNB2;GRB2;CDK5;SDCBP
metal ion bindingERCC5;MTMR3;Reln;ZFP276;PRDM12B;RYBPA;MARCH4;RPE;ZMYND10
protein bindingTRAPPC6B;TXN;MEX3C;C22orf28;RAC1;TARS;TAF7L;TFF2;CTIF

CHN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHN1.

NCK2; HEMK1; CDK5R1; ERBB2; RPS3A; GTF3C1; MAPK8IP2

Iwata, R; Ohi, K; et al. RacGAP alpha 2-Chimaerin Function in Development Adjusts Cognitive Ability in Adulthood. CELL REPORTS 8:1257-1264(2014).
Ferreiro, JF; Rouhigharabaei, L; et al. Integrative Genomic and Transcriptomic Analysis Identified Candidate Genes Implicated in the Pathogenesis of Hepatosplenic T-Cell Lymphoma. PLOS ONE 9:-(2014).
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