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CHRNG

Official Full Name

cholinergic receptor, nicotinic, gamma
Overview

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
Synonyms

CHRNG; cholinergic receptor, nicotinic, gamma; ACHRG, cholinergic receptor, nicotinic, gamma polypeptide; acetylcholine receptor subunit gamma; Acetylcholine receptor muscle gamma subunit; Acetylcholine receptor protein gamma chain precursor; ACHG; Achr 3; Achr3; ACHRG; ACRG; Cholinergic receptor nicotinic gamma; Cholinergic receptor nicotinic gamma polypeptide; MGC133376; OTTHUMP00000203703; OTTHUMP00000203704; acetylcholine receptor, muscle, gamma subunit; cholinergic receptor, nicotinic, gamma polypeptide;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
E.Coli or Yeast
HEK293
Mammalian Cell
Yeast

Tag

His
His (Fc)
Avi
N
GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CHRNG-1839H	Recombinant Human CHRNG Protein, His-tagged	Yeast	His		Inquiry
Human	CHRNG-1730H	Recombinant Human CHRNG Protein (Arg23-Ala250), N-His tagged	E.coli	N-His	Arg23-Ala250	Inquiry
Human	CHRNG-783H	Recombinant Human CHRNG Protein, His&GST-tagged	E.coli	N-His&GST	Arg23-Ala250	Inquiry
Mouse	Chrng-3058M	Recombinant Mouse Chrng, His-tagged	E.Coli or Yeast	His	519	Inquiry
Rat	CHRNG-1402R	Recombinant Rat CHRNG Protein	Mammalian Cell	His		Inquiry
Rat	CHRNG-1060R-B	Recombinant Rat CHRNG Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	CHRNG-1060R	Recombinant Rat CHRNG Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	CHRNG-8109Z	Recombinant Zebrafish CHRNG	Mammalian Cell	His		Inquiry
Chicken	CHRNG-3210C	Recombinant Chicken CHRNG	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CHRNG involved in several pathways and played different roles in them. We selected most pathways CHRNG participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neuroactive ligand-receptor interaction	OPRD1A;GRIK2;TAAR11;HTR2CL1;RXFP2A;DRD1B;TAAR15;P2RX2;CHRNB3

CHRNG has several biochemical functions, for example, acetylcholine-activated cation-selective channel activity, extracellular ligand-gated ion channel activity, ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNG itself. We selected most functions CHRNG had, and list some proteins which have the same functions with CHRNG. You can find most of the proteins on our site.

Function	Related Protein
acetylcholine-activated cation-selective channel activity	CHRNB1L;CHRNA7;CHRNB4;CHRNA10A;CHRNB3;CHRNA4;Chrng;CHRNA2;CHRNE
extracellular ligand-gated ion channel activity	SIX2A;GABRR3;CHRNA4B;CHRNB3A;GABRD;CHRNA2A;GLRBA;GLRBB;GABRR2A
ion channel activity	GRIN2BB;CLCN6;CATSPER2;TRPV2;CLCN4-2;HTR3B;TRPC7B;TRPC4A;TPCN1
ligand-gated ion channel activity	ANXA6;TRPA1B;TRPA1A;P2RX2;CHRNB2;CLCA2;Chrng;CLCA5;CHRNA4
protein binding	PROCR;ANKRD1;SCYL3;TAL2;GNS;NLGN4Y;MAP4K5;KIAA0408;FAM109B

CHRNG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNG here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNG.