CLDN3
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Official Full Name
claudin 3
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Overview
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene. -
Synonyms
CLDN3; claudin 3; C7orf1, CPETR2; claudin-3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; HRVP1; RVP1; ventral prostate.1 like protein; CPE-R 2; CPE-receptor 2; ventral prostate.1-like protein; ventral prostate.1 protein homolog;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Baculovirus-Insect cells
- E. coli
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Protein Conjugation
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- B2M
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CLDN3-0298H | Active Recombinant Human CLDN3 Full Length Transmembrane protein(Nanodisc) | HEK293 | N/A | ||
Human | CLDN3-27271TH | Recombinant Human CLDN3 | Wheat Germ | N/A | 220 amino acids | |
Human | CLDN3-1442H | Recombinant Human CLDN3 Protein, GST-tagged | Wheat Germ | GST | ||
Human | CLDN3-11295H | Recombinant Human CLDN3, GST-tagged | E.coli | GST | 1-220a.a. | |
Human | CLDN3-7463HCL | Recombinant Human CLDN3 293 Cell Lysate | HEK293 | N/A | ||
Human | CLDN3-2700H | Recombinant Human CLDN3 protein, His-B2M-tagged | E.coli | His-B2M | 30-80aa | |
Human | CLDN3-10H | Active Recombinant Human CLDN3 Full Length Full Length Transmembrane protein, His-tagged(VLPs) | HEK293 | His | 1-220aa | |
Human | CLDN3-0332H | Recombinant Human CLDN3 Protein (Met1-Val220), C-His-tagged | Baculovirus-Insect cells | C-His | Met1-Val220 | |
Human | CLDN3-11293H | Recombinant Human CLDN3 protein, His-tagged | E. coli | His | Arg30~Arg80 | |
Human | CLDN3-2789H | Recombinant Human CLDN3 Protein, His-tagged, OVA Conjugated | Protein Conjugation | N-His | Trp137-Met159 | |
Human | CLDN3-2055HF | Recombinant Full Length Human CLDN3 Protein, GST-tagged | In Vitro Cell Free System | GST | 220 amino acids | |
Human | CLDN3-1537H | Recombinant Human CLDN3 Full Length Transmembrane protein, His-tagged | In vitro E. coli expression system | His | 1-220aa | |
Human | CLDN3-84HF | Recombinant Full Length Human CLDN3 Protein | In Vitro Cell Free System | 220 amino acids | ||
Mouse | Cldn3-1427M | Recombinant Mouse Cldn3 protein, His-tagged | E.coli | His | Arg30~Met159 (Accession # Q9Z0G9) | |
Rat | CLDN3-1435R | Recombinant Rat CLDN3 Protein | Mammalian Cell | His | ||
Rat | CLDN3-1093R-B | Recombinant Rat CLDN3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | CLDN3-1093R | Recombinant Rat CLDN3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Bos taurus (Bovine) | RFL16043BF | Recombinant Full Length Bovine Claudin-3(Cldn3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-219) | |
Canis lupus familiaris (Dog) (Canis familiaris) | RFL34064CF | Recombinant Full Length Dog Claudin-3(Cldn3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-218) | |
Homo sapiens (Human) | RFL4935HF | Recombinant Full Length Human Claudin-3(Cldn3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-220aa) | |
Mus musculus (Mouse) | RFL32043MF | Recombinant Full Length Mouse Claudin-3(Cldn3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-219) | |
Rattus norvegicus (Rat) | RFL28625RF | Recombinant Full Length Rat Claudin-3(Cldn3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-219) | |
Rhesus Macaque | CLDN3-895R | Recombinant Rhesus monkey CLDN3 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | CLDN3-721R-B | Recombinant Rhesus Macaque CLDN3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | CLDN3-721R | Recombinant Rhesus Macaque CLDN3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Chicken | CLDN3-5776C | Recombinant Chicken CLDN3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- CLDN3 Related Articles
- CLDN3 Related Research Area
CLDN3 involved in several pathways and played different roles in them. We selected most pathways CLDN3 participated on our site, such as Cell adhesion molecules (CAMs), Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell adhesion molecules (CAMs) | CLDN14;Siglec1;SELP;CLDNE;CNTN1A;ALCAMA;MHC2DAB;HLA-DRB1;HLA-DRA |
Cell junction organization | FBLIM1;CDH5;ANG;CD151;ITGB1B.1;DST;CDH18;LIMS1;CDH12A |
Cell-Cell communication | CDH4;KIRREL3L;CDH10A;CDH3;PARVB;CLDN23;DSCAMA;SIRPA;DCC |
Cell-cell junction organization | CDH7;CDH18;PVRL2L;CADM2;CLDN3;CDH9;CDH12A;CDH10;CDH11 |
Hepatitis C | TRAF6;IFNB1;MAPK1;STAT2;SCARB1;CLDN18;CLDN9;PIK3R2;PIK3R3 |
Leukocyte transendothelial migration | MAPK12;VAV1;PTK2;ROCK1;EZR;MYL9;CXCL12;GNAI1;MLLT4 |
Tight junction | CLDN5B;MYHZ2;MYH11;EPB41L1;PPP2R2D;RAB13;MYL9B;ASH1L;PRKCHA |
Tight junction interactions | CLDN20;CLDN3;INADL;CLDN7;CLDN4;CLDN16;CLDN23 |
CLDN3 has several biochemical functions, for example, identical protein binding, structural molecule activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN3 itself. We selected most functions CLDN3 had, and list some proteins which have the same functions with CLDN3. You can find most of the proteins on our site.
Function | Related Protein |
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identical protein binding | SNRNP200;PDGFB;DYNLT3;ATXN3;PRC1;TTR;BAK1;WRNIP1;PCBD1 |
structural molecule activity | CLDN23;NES;KRT31;INAB;SPRR1B;PNN;SNTA1;CLDN19;CLDN14 |
transmembrane signaling receptor activity | IL11RA;TLR10;KIR2DL4;KLRC3;TLR1;LEPR;TLR9;CD69;ADCYAP1R1A |
CLDN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN3.
- Q&As
- Reviews
Q&As (5)
Ask a questionResearchers are exploring the use of CLDN3 as a target for drug delivery systems, aiming to enhance the specificity of drug delivery to tissues expressing high levels of CLDN3.
CLDN3 is involved in the tight junctions of intestinal epithelial cells, influencing the permeability of the intestinal barrier and playing a role in conditions like IBD.
CLDN3 is under investigation in various conditions, including infectious diseases, where its role in tight junctions may have implications for host-pathogen interactions.
Yes, CLDN3 is implicated in the pathogenesis of inflammatory bowel diseases, and its expression levels are being studied as potential markers for disease severity.
Altered expression of CLDN3 in the blood-brain barrier is associated with certain neurodegenerative diseases, making it a subject of interest for researchers studying these conditions.
Customer Reviews (3)
Write a reviewThe manufacturer's deep understanding of the protein and its applications enables them to promptly and effectively address any issues that may arise during my trials.
It minimizes the risk of protein degradation and maximizes the effectiveness of the protein in various applications, such as cell signaling pathways or metabolic studies.
This stability is particularly advantageous for long-term studies or experiments involving extended incubation periods.
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