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CLDN3

  • Official Full Name

    claudin 3

  • Overview

    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    CLDN3; claudin 3; C7orf1, CPETR2; claudin-3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; HRVP1; RVP1; ventral prostate.1 like protein; CPE-R 2; CPE-receptor 2; ventral prostate.1-like protein; ventral prostate.1 protein homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Baculovirus-Insect cells
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Protein Conjugation
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • B2M
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLDN3-0298H Active Recombinant Human CLDN3 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CLDN3-27271TH Recombinant Human CLDN3 Wheat Germ N/A 220 amino acids
Human CLDN3-1442H Recombinant Human CLDN3 Protein, GST-tagged Wheat Germ GST
Human CLDN3-11295H Recombinant Human CLDN3, GST-tagged E.coli GST 1-220a.a.
Human CLDN3-7463HCL Recombinant Human CLDN3 293 Cell Lysate HEK293 N/A
Human CLDN3-2700H Recombinant Human CLDN3 protein, His-B2M-tagged E.coli His-B2M 30-80aa
Human CLDN3-10H Active Recombinant Human CLDN3 Full Length Full Length Transmembrane protein, His-tagged(VLPs) HEK293 His 1-220aa
Human CLDN3-0332H Recombinant Human CLDN3 Protein (Met1-Val220), C-His-tagged Baculovirus-Insect cells C-His Met1-Val220
Human CLDN3-11293H Recombinant Human CLDN3 protein, His-tagged E. coli His Arg30~Arg80
Human CLDN3-2789H Recombinant Human CLDN3 Protein, His-tagged, OVA Conjugated Protein Conjugation N-His Trp137-Met159
Human CLDN3-2055HF Recombinant Full Length Human CLDN3 Protein, GST-tagged In Vitro Cell Free System GST 220 amino acids
Human CLDN3-1537H Recombinant Human CLDN3 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-220aa
Human CLDN3-84HF Recombinant Full Length Human CLDN3 Protein In Vitro Cell Free System 220 amino acids
Mouse Cldn3-1427M Recombinant Mouse Cldn3 protein, His-tagged E.coli His Arg30~Met159 (Accession # Q9Z0G9)
Rat CLDN3-1435R Recombinant Rat CLDN3 Protein Mammalian Cell His
Rat CLDN3-1093R-B Recombinant Rat CLDN3 Protein Pre-coupled Magnetic Beads HEK293
Rat CLDN3-1093R Recombinant Rat CLDN3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL16043BF Recombinant Full Length Bovine Claudin-3(Cldn3) Protein, His-Tagged E.coli expression system His Full Length (1-219)
Canis lupus familiaris (Dog) (Canis familiaris) RFL34064CF Recombinant Full Length Dog Claudin-3(Cldn3) Protein, His-Tagged E.coli expression system His Full Length (1-218)
Homo sapiens (Human) RFL4935HF Recombinant Full Length Human Claudin-3(Cldn3) Protein, His-Tagged E.coli expression system His Full Length (1-220aa)
Mus musculus (Mouse) RFL32043MF Recombinant Full Length Mouse Claudin-3(Cldn3) Protein, His-Tagged E.coli expression system His Full Length (1-219)
Rattus norvegicus (Rat) RFL28625RF Recombinant Full Length Rat Claudin-3(Cldn3) Protein, His-Tagged E.coli expression system His Full Length (1-219)
Rhesus Macaque CLDN3-895R Recombinant Rhesus monkey CLDN3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CLDN3-721R-B Recombinant Rhesus Macaque CLDN3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CLDN3-721R Recombinant Rhesus Macaque CLDN3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CLDN3-5776C Recombinant Chicken CLDN3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CLDN3 Related Articles
  • CLDN3 Related Research Area

CLDN3 involved in several pathways and played different roles in them. We selected most pathways CLDN3 participated on our site, such as Cell adhesion molecules (CAMs), Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CLDN14;Siglec1;SELP;CLDNE;CNTN1A;ALCAMA;MHC2DAB;HLA-DRB1;HLA-DRA
Cell junction organizationFBLIM1;CDH5;ANG;CD151;ITGB1B.1;DST;CDH18;LIMS1;CDH12A
Cell-Cell communicationCDH4;KIRREL3L;CDH10A;CDH3;PARVB;CLDN23;DSCAMA;SIRPA;DCC
Cell-cell junction organizationCDH7;CDH18;PVRL2L;CADM2;CLDN3;CDH9;CDH12A;CDH10;CDH11
Hepatitis CTRAF6;IFNB1;MAPK1;STAT2;SCARB1;CLDN18;CLDN9;PIK3R2;PIK3R3
Leukocyte transendothelial migrationMAPK12;VAV1;PTK2;ROCK1;EZR;MYL9;CXCL12;GNAI1;MLLT4
Tight junctionCLDN5B;MYHZ2;MYH11;EPB41L1;PPP2R2D;RAB13;MYL9B;ASH1L;PRKCHA
Tight junction interactionsCLDN20;CLDN3;INADL;CLDN7;CLDN4;CLDN16;CLDN23

CLDN3 has several biochemical functions, for example, identical protein binding, structural molecule activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN3 itself. We selected most functions CLDN3 had, and list some proteins which have the same functions with CLDN3. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingSNRNP200;PDGFB;DYNLT3;ATXN3;PRC1;TTR;BAK1;WRNIP1;PCBD1
structural molecule activityCLDN23;NES;KRT31;INAB;SPRR1B;PNN;SNTA1;CLDN19;CLDN14
transmembrane signaling receptor activityIL11RA;TLR10;KIR2DL4;KLRC3;TLR1;LEPR;TLR9;CD69;ADCYAP1R1A

CLDN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN3.

Ricardo, S; Gerhard, R; et al. Claudin expression in breast cancer: High or low, what to expect?. HISTOLOGY AND HISTOPATHOLOGY 27:1283-1295(2012).
Meng, J; Greenlee, AR; et al. Sertoli Cell-Specific Deletion of the Androgen Receptor Compromises Testicular Immune Privilege in Mice. BIOLOGY OF REPRODUCTION 85:254-260(2011).
  • Q&As
  • Reviews

Q&As (5)

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Is CLDN3 a potential target for drug delivery to specific tissues? 05/06/2021

Researchers are exploring the use of CLDN3 as a target for drug delivery systems, aiming to enhance the specificity of drug delivery to tissues expressing high levels of CLDN3.

How does CLDN3 impact the permeability of the intestinal epithelium? 01/15/2021

CLDN3 is involved in the tight junctions of intestinal epithelial cells, influencing the permeability of the intestinal barrier and playing a role in conditions like IBD.

In which other diseases or conditions is CLDN3 being investigated? 04/16/2019

CLDN3 is under investigation in various conditions, including infectious diseases, where its role in tight junctions may have implications for host-pathogen interactions.

Can CLDN3 be involved in inflammatory bowel diseases (IBD)? 02/02/2018

Yes, CLDN3 is implicated in the pathogenesis of inflammatory bowel diseases, and its expression levels are being studied as potential markers for disease severity.

How is CLDN3 linked to neurodegenerative diseases? 10/26/2016

Altered expression of CLDN3 in the blood-brain barrier is associated with certain neurodegenerative diseases, making it a subject of interest for researchers studying these conditions.

Customer Reviews (3)

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Reviews
04/24/2019

    The manufacturer's deep understanding of the protein and its applications enables them to promptly and effectively address any issues that may arise during my trials.

    06/30/2018

      It minimizes the risk of protein degradation and maximizes the effectiveness of the protein in various applications, such as cell signaling pathways or metabolic studies.

      12/12/2017

        This stability is particularly advantageous for long-term studies or experiments involving extended incubation periods.

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