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CLEC4E

  • Official Full Name

    C-type lectin domain family 4, member E

  • Overview

    This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
  • Synonyms

    CLEC4E; C-type lectin domain family 4, member E; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , CLECSF9; C-type lectin domain family 4 member E; mincle; C type lectin domain family 4 member E; C type lectin superfamily member 9; C-type (calcium dependent carbohydrate recognition domain) lectin superfamily member 9; CLEC 4E; CLECSF9; Macrophage inducible C type lectin; OTTHUMP00000239175; OTTHUMP00000239177; C-type lectin superfamily member 9; macrophage-inducible C-type lectin; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Strep
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLEC4E-1469H Recombinant Human CLEC4E Protein, GST-tagged Wheat Germ GST
Human CLEC4E-7776H Recombinant Human CLEC4E, His-tagged HEK293 His
Human CLEC4E-15H Recombinant Human CLEC4E protein, His-tagged E.coli His
Human CLEC4E-7450HCL Recombinant Human CLEC4E 293 Cell Lysate HEK293 N/A
Human CLEC4E-679HFL Recombinant Full Length Human CLEC4E Protein, C-Flag-tagged Mammalian cells Flag
Human CLEC4E-2109H Recombinant Human CLEC4E Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CLEC4E-7777H Active Recombinant Human CLEC4E Protein, Fc-tagged CHO Fc
Human CLEC4E-2160HF Recombinant Full Length Human CLEC4E Protein, GST-tagged In Vitro Cell Free System GST 219 amino acids
Human CLEC4E-2076H Recombinant Human CLEC4E Protein (Arg41-Leu219), C-His tagged Mammalian cells C-His Arg41-Leu219
Human CLEC4E-7778H Recombinant Human CLEC4E Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human CLEC4E-0195H Recombinant Human CLEC4E Protein (G74-L219), His/Strep tagged E.coli His/Strep G74-L219
Human CLEC4E-615H Recombinant Human CLEC4E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CLEC4E-2077H Recombinant Human CLEC4E Protein (Arg41-Leu219), N-Fc tagged Mammalian cells N-Fc Arg41-Leu219
Human CLEC4E-0194H Recombinant Human CLEC4E Protein (G74-L219), Flag tagged E.coli Flag G74-L219
Human CLEC4E-615H-B Recombinant Human CLEC4E Protein Pre-coupled Magnetic Beads HEK293
Mouse Clec4e-284M Active Recombinant Mouse Clec4e protein, Fc-tagged CHO Fc
Mouse CLEC4E-2057M Recombinant Mouse CLEC4E Protein (46-214 aa), His-tagged E.coli His 46-214 aa
Mouse Clec4e-2187M Recombinant Mouse Clec4e Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CLEC4E-1444R Recombinant Rat CLEC4E Protein Mammalian Cell His
Rat CLEC4E-1102R-B Recombinant Rat CLEC4E Protein Pre-coupled Magnetic Beads HEK293
Rat CLEC4E-1102R Recombinant Rat CLEC4E Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CLEC4E-290C Recombinant Cynomolgus CLEC4E protein, Fc-tagged HEK293 Fc
Rhesus Macaque CLEC4E-1199R Recombinant Rhesus CLEC4E Protein, Fc-tagged HEK293 Fc
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CLEC4E Related Articles

CLEC4E involved in several pathways and played different roles in them. We selected most pathways CLEC4E participated on our site, such as Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC4E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TuberculosisSPHK2;PPP3R1;MAPK9;H2-AB1;NFYC;CASP10;FCGR4;IFNA12;ITGB2

CLEC4E has several biochemical functions, for example, carbohydrate binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC4E itself. We selected most functions CLEC4E had, and list some proteins which have the same functions with CLEC4E. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingGALNT18A;PKD1;CLEC1B;Cd24a;LGALS13;CDIPT;GALNT7;CLEC5A;CHI3L1
receptor activityGABRA5;ANTXR2A;MED1;ANTXRL;SEMA4D;GRIN3B;MED17;NLGN2;DERL1

CLEC4E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC4E here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC4E.

Zhao, XQ; Zhu, LL; et al. C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6 '-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-kappa B Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:30052-30062(2014).
Kataoka, H; Kono, H; et al. Evaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (5)

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Can CLEC4E protein be targeted for the treatment of autoimmune diseases? 04/01/2022

While the role of CLEC4E in autoimmune diseases is still being investigated, targeting CLEC4E may hold potential for modulating immune responses in certain autoimmune conditions.

How does CLEC4E protein contribute to immune responses? 07/23/2021

CLEC4E protein activates immune cells and initiates inflammatory responses upon recognition of pathogen-associated molecular patterns (PAMPs).

Is CLEC4E protein involved in antiviral immune responses? 01/26/2021

Yes, CLEC4E is involved in recognizing viral pathogens and triggering immune responses to combat viral infections.

How does CLEC4E protein interact with other immune receptors? 07/12/2019

CLEC4E can collaborate with other immune receptors, such as TLRs (Toll-like receptors), to amplify immune responses upon pathogen detection.

Are there any specific diseases where targeting CLEC4E shows promise? 10/15/2017

Targeting CLEC4E holds promise in the development of vaccines and immunotherapies against infectious diseases, including tuberculosis and fungal infections.

Customer Reviews (3)

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Reviews
10/24/2022

    The CLEC4E protein is an exceptional protein solution that exceeds expectations in terms of quality and suitability for my experimental requirements.

    01/01/2021

      I am confident that utilizing the CLEC4E protein will empower me to uncover crucial insights into cellular mechanisms with precision.

      03/11/2020

        In addition to its outstanding quality, the CLEC4E protein comes with exceptional technical support from its manufacturer.

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