CLEC4E
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Official Full Name
C-type lectin domain family 4, member E
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Overview
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. -
Synonyms
CLEC4E; C-type lectin domain family 4, member E; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , CLECSF9; C-type lectin domain family 4 member E; mincle; C type lectin domain family 4 member E; C type lectin superfamily member 9; C-type (calcium dependent carbohydrate recognition domain) lectin superfamily member 9; CLEC 4E; CLECSF9; Macrophage inducible C type lectin; OTTHUMP00000239175; OTTHUMP00000239177; C-type lectin superfamily member 9; macrophage-inducible C-type lectin; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- CHO
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Fc
- Flag
- GST
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CLEC4E Related Articles
CLEC4E involved in several pathways and played different roles in them. We selected most pathways CLEC4E participated on our site, such as Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC4E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Tuberculosis | SPHK2;PPP3R1;MAPK9;H2-AB1;NFYC;CASP10;FCGR4;IFNA12;ITGB2 |
CLEC4E has several biochemical functions, for example, carbohydrate binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC4E itself. We selected most functions CLEC4E had, and list some proteins which have the same functions with CLEC4E. You can find most of the proteins on our site.
Function | Related Protein |
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carbohydrate binding | GALNT18A;PKD1;CLEC1B;Cd24a;LGALS13;CDIPT;GALNT7;CLEC5A;CHI3L1 |
receptor activity | GABRA5;ANTXR2A;MED1;ANTXRL;SEMA4D;GRIN3B;MED17;NLGN2;DERL1 |
CLEC4E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC4E here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC4E.
- Q&As
- Reviews
Q&As (5)
Ask a questionWhile the role of CLEC4E in autoimmune diseases is still being investigated, targeting CLEC4E may hold potential for modulating immune responses in certain autoimmune conditions.
CLEC4E protein activates immune cells and initiates inflammatory responses upon recognition of pathogen-associated molecular patterns (PAMPs).
Yes, CLEC4E is involved in recognizing viral pathogens and triggering immune responses to combat viral infections.
CLEC4E can collaborate with other immune receptors, such as TLRs (Toll-like receptors), to amplify immune responses upon pathogen detection.
Targeting CLEC4E holds promise in the development of vaccines and immunotherapies against infectious diseases, including tuberculosis and fungal infections.
Customer Reviews (3)
Write a reviewThe CLEC4E protein is an exceptional protein solution that exceeds expectations in terms of quality and suitability for my experimental requirements.
I am confident that utilizing the CLEC4E protein will empower me to uncover crucial insights into cellular mechanisms with precision.
In addition to its outstanding quality, the CLEC4E protein comes with exceptional technical support from its manufacturer.
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