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COL10A1

  • Official Full Name

    collagen, type X, alpha 1

  • Overview

    This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).
  • Synonyms

    COL10A1; collagen, type X, alpha 1; collagen alpha-1(X) chain; collagen X, alpha-1 polypeptide; Schmid metaphyseal chondrodysplasia<br/>;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Flag
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COL10A1-88H Recombinant Human COL10A1, MYC/DDK-tagged HEK293 Myc/DDK
Human COL10A1-85H Recombinant Human COL10A1, His-tagged Insect Cell His
Human COL10A1-490H Recombinant Human COL10A1 protein, His-tagged E.coli His Thr547~Met680
Human COL10A1-3829H Recombinant Human COL10A1 protein, His-tagged E.coli His 157-412 aa
Human COL10A1-1773H Recombinant Human COL10A1 Protein (Thr547-Met680), His tagged E.coli His Thr547-Met680
Human COL10A1-4344HFL Recombinant Full Length Human COL10A1, Flag-tagged Mamanlian cells Flag
Mouse COL10A1-3713M Recombinant Mouse COL10A1 Protein Mammalian Cell His
Mouse COL10A1-1845M-B Recombinant Mouse COL10A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Col10a1-350M Recombinant Mouse Col10a1 Protein, His-tagged E.coli His Thr547~Met680
Mouse Col10a1-915M Recombinant Mouse Col10a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse COL10A1-1845M Recombinant Mouse COL10A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey COL10A1-1769R Recombinant Rhesus monkey COL10A1 protein, His-tagged E.coli His Thr547~Met680
Bovine COL10A1-348B Recombinant Bovine COL10A1 Protein, His-tagged E.coli His Ala547~Met674
Rhesus Macaque COL10A1-959R Recombinant Rhesus monkey COL10A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque COL10A1-784R-B Recombinant Rhesus Macaque COL10A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque COL10A1-784R Recombinant Rhesus Macaque COL10A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COL10A1 Related Articles
  • COL10A1 Related Research Area

COL10A1 involved in several pathways and played different roles in them. We selected most pathways COL10A1 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL10A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Assembly of collagen fibrils and other multimeric structuresCTSL2;COL10A1A;CTSB;MMP13;COL4A5;LOXL2;COL5A2;LOXL4;COL5A1
Collagen biosynthesis and modifying enzymesTLL1;COL6A1;BMP1;COL5A3B;ADAMTS2;P3H2;COL23A1;LEPREL2;COL4A6
Collagen formationCOL5A3A;DST;BMP1B;PCOLCE;BMP1;COL4A3;COL6A2;CTSS;PCOLCE2
Endochondral OssificationPTHLHA;SOX9A;KIF3A;PTH;MMP13;ADAMTS4;CTSL2;SOX6;IFT88
Extracellular matrix organizationCOL10A1;COL1A1;COL4A4;COL13A1;MMP10;EFEMP1;MFAP1;LOXL2;COL9A1A
Protein digestion and absorptionCOL18A1;SLC8A2;COL6A6;COL13A1;ATP1B2;COL15A1;SLC3A1;PRCP;CPB1
Senescence and AutophagyING2;ING1;SLC39A3;SLC39A2;GABARAP;IFI16;AMBRA1;FKBP8;UVRAG

COL10A1 has several biochemical functions, for example, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL10A1 itself. We selected most functions COL10A1 had, and list some proteins which have the same functions with COL10A1. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingSPRTN;GALNT4;MAT1A;ZNF167;RIMS1;TRIM55B;HEPHL1A;BTR12;MMP14A
protein bindingMMACHC;PAAF1;ODF2;HIST1H2AI;MAPK14;CCDC43;DOK6;VIP;FAM114A1

COL10A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL10A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL10A1.

BANP; UBQLN1; UBQLN1; P4HB

Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
Alaseem, AM; Madiraju, P; et al. Naproxen Induces Type X Collagen Expression in Human Bone-Marrow-Derived Mesenchymal Stem Cells Through the Upregulation of 5-Lipoxygenase. Tissue Engineering Part A 21:234-245(2015).
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