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COL1A1

  • Official Full Name

    collagen, type I, alpha 1

  • Overview

    Collagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Collagen type II is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
  • Synonyms

    COL1A1; collagen, type I, alpha 1; collagen alpha-1(I) chain; OI4; alpha-1 type I collagen; pro-alpha-1 collagen type 1; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain;

  • Recombinant Proteins
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Mammalian Cell
  • P.pastoris
  • Tissue
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COL1A1-113H Recombinant Human COL1A1, GST-tagged Wheat Germ GST
Human COL1A1-66H Recombinant Human COL1A1 protein, His-tagged E.coli His Arg253~Ala471
Human COL1A1-1207H Recombinant Human COL1A1 / Collagen, Type I, Alpha 1 protein P.pastoris N/A
Human COL1A1-1206H Recombinant Human Collagen, Type I, Alpha 1 P.pastoris N/A
Human COL1A1-71H Recombinant Human COL1A1 protein E.coli N/A
Human COL1A1-114H Recombinant Human COL1A1 Protein, His-tagged CHO His
Human COL1A1-67H Recombinant Human COL1A1 protein, His-tagged E.coli His Ala1218~Ile1440
Human COL1A1-813H Recombinant Human COL1A1 Protein, His&GST-tagged E.coli N-His&GST Ala1218-Leu1464
Human COL1A1-1226H Recombinant Human COL1A1 protein, GST-tagged E.coli GST
Human COL1A1-815H Recombinant Human COL1A1 Protein, His-tagged HEK293F N-His Asp1219-Leu1464
Human COL1A1-001H Recombinant Human COL1A1 Protein, His-tagged HEK293T His
Human COL1A1-1756H Recombinant Human COL1A1 Protein (Ala396-Asp744), N-His tagged E.coli N-His Ala396-Asp744
Human COL1A1-814H Recombinant Human COL1A1 Protein, His-tagged E.coli N-His Asp1219-Leu1464
Human COL1A1-1183H Recombinant Human COL1A1 Protein, His-tagged HEK293F N-His Gln23-Pro161
Human COL1A1-12H Recombinant Human COL1A1 Protein (Gln300-Asp744), N-His tagged HEK293 N-His Gln300-Asp744
Human COL1A1-01H Recombinant Human COL1A1 protein, His-tagged HEK293 His 1464 aa
Human COL1A1-116H Recombinant Human Collagen, Type I, Alpha 1 P.pastoris N/A
Human COL1A1-1761H Recombinant Human COL1A1 Protein (Gly1094-Leu1464), His tagged E.coli His Gly1094-Leu1464
Human COL1A1-1758H Recombinant Human COL1A1 Protein (Gln23-Lys237), N-His tagged E.coli N-His Gln23-Lys237
Human COL1A1-2523H Recombinant Human COL1A1 protein(1021-1110 aa), C-His-tagged E. coli C-His 1021-1110 aa
Human COL1A1-1760H Recombinant Human COL1A1 Protein (Gln23-Pro161), N-His tagged E.coli N-His Gln23-Pro161
Human COL1A1-26195TH Native Human COL1A1 N/A
Mouse Col1a1-08M Recombinant Mouse Col1a1 protein, His-tagged HEK293 His
Mouse Col1a1-09M Recombinant Mouse Col1a1 protein, His-tagged E.coli His Lys1225~Val1453
Mouse COL1A1-23M Native Mouse Collagen I Protein N/A
Mouse Col1a1-7174M Native Mouse Col1a1 Protein Tissue
Mouse Col1a1-1278M Recombinant Mouse Col1a1 Protein, His&GST-tagged E.coli N-His&GST Gln23-Ser151
Mouse Col1a1-1277M Recombinant Mouse Col1a1 Protein, His-tagged E.coli N-His Asp1208-Val1453
Mouse Col1a1-816M Recombinant Mouse Col1a1 Protein, His&GST-tagged E.coli N-His&GST Gly22-Ser154
Rat COL1A1-1517R Recombinant Rat COL1A1 Protein Mammalian Cell His
Rat COL1A1-1174R Recombinant Rat COL1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Col1a1-817R Recombinant Rat Col1a1 Protein, His-tagged E.coli N-His Gly22-Ser154
Rat Col1a1-1276R Recombinant Rat Col1a1 Protein, His&GST-tagged E.coli N-His&GST Gln23-Ser151
Rat COL1A1-1174R-B Recombinant Rat COL1A1 Protein Pre-coupled Magnetic Beads HEK293
Rat Col1a1-5382R Recombinant Rat Col1a1 protein, His-tagged Yeast His 955-1207aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COL1A1 Related Articles
  • COL1A1 Related Research Area

COL1A1 involved in several pathways and played different roles in them. We selected most pathways COL1A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AmoebiasisCOL24A1;MUC2;SERPINB1A;NOS2;TGFB1;COL1A2;GNA14;SERPINB10;TLR4
Assembly of collagen fibrils and other multimeric structuresCOL4A4;COL6A3;CD151;LOXL1;BMP1B;COL5A3B;LOXL3;COL1A2;COL8A1
Binding and Uptake of Ligands by Scavenger ReceptorsIGLC2;SAA1;IGKC;Alb;NFX1;SPARC;IGKV1-5;HSPH1;HP
Collagen biosynthesis and modifying enzymesCOL4A6;COL1A2;COL4A4;COL17A1;COL2A1;BMP1B;COL4A5;ADAMTS2;PCOLCE2B
Collagen formationCOL28A1;LEPREL2;COL5A2;PCOLCEA;SERPINH1B;PCOLCE;CTSL2;COL4A4;CRTAP
ECM-receptor interactionITGB8;THBS3A;COL27A1;TNN;VTNA;ITGA11A;COL11A1A;LAMC3;ITGA2
Extracellular matrix organizationTTR;MMP12;BGNB;COL10A1A;COL6A1;COL17A1;MMP8;COL8A1A;COL8A2
Focal AdhesionHRASA;XIAP;VCL;ROCK2A;ITGA7;CAV3;ITGB1;ITGB6;HRAS

COL1A1 has several biochemical functions, for example, extracellular matrix structural constituent, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL1A1 itself. We selected most functions COL1A1 had, and list some proteins which have the same functions with COL1A1. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix structural constituentPRELP;COL1A2;IMPG2;MEPE;LAMA4;CHI3L1;KAL1;FBLN2;COL5A2
identical protein bindingHSPB8;PAFAH1B3;PRPF3;PRDX3;RIPK1;CLDN16;SNX8;SCHIP1;SHARPIN
metal ion bindingRUFY2;ZFP319;ALDH1A2;YY1A;PPM1K;CYP3C1L2;ZFP41;HBA-X;ZBTB44
platelet-derived growth factor bindingCOL6A1;COL3A1;COL2A1;PDGFRA;COL5A1;COL1A2;COL4A1;PDGFRB;PDGFA
protein bindingHRASLS5;SLPI;EPS8L1;CCNL2;OLIG3;KHK;ERCC6;PFN2;ORAI2

COL1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL1A1.

all3_aedae; COCH; FN1; q5yb85_strsg; TFAP2A; ZNF16; LOX; yscP; q5nfy4_fratt; thrS2; syd; q8d1r8_yerpe; queA; TFAP2C; ATP13A2; irp1

Sinder, BP; Salemi, JD; et al. Rapidly growing Brtl/ plus mouse model of osteogenesis imperfecta improves bone mass and strength with sclerostin antibody treatment. BONE 71:115-123(2015).
Noh, SMM; Kadir, SHSA; et al. Effects of ranibizumab on the extracellular matrix production by human Tenon's fibroblast. EXPERIMENTAL EYE RESEARCH 127:236-242(2014).
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