COMP
-
Official Full Name
cartilage oligomeric matrix protein
-
Overview
Cartilage oligomeric matrix protein is a protein that in humans is encoded by the COMP gene. The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) -
Synonyms
COMP; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , EDM1, EPD1, PSACH; MED; THBS5; thrombospondin 5; TSP5; thrombospondin-5; pseudoachondroplasia (epiphyseal dysplasia 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bacillus subtilis
- Human
- Mouse
- Rat
- CHO
- E. coli or Yeast
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- COMP Related Articles
- COMP Related Research Area
COMP involved in several pathways and played different roles in them. We selected most pathways COMP participated on our site, such as ECM proteoglycans, ECM-receptor interaction, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with COMP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
ECM proteoglycans | LRP4;BGNB;PTPRS;MATN1;COL9A1;FMOD;BGNA;SPARC;COMP |
ECM-receptor interaction | THBS3A;Reln;VTN;CD44;VTNA;ITGB7;IBSP;ITGA4;COL4A5 |
Extracellular matrix organization | COL23A1;PCOLCE;DAG1;BMP10;PPIB;TIMP2A;MMP17;MATN3B;BMP1A |
Focal Adhesion | PDGFAA;ITGB4;ITGB7;PPP1R12C;MYL9;LAMA5;ROCK1;CDC42;PARVAA |
Integrin cell surface interactions | COL13A1;BSG;FBN1;LOC100514666;COMP;COL23A1;COL16A1;F11R.2;COL9A1B |
Malaria | HBB-B2;TGFB1;HBA2;IL1B;DARC;TGFB3;VCAM1;TNF;MET |
PI3K-Akt signaling pathway | CSH;EFNA2;LOC608458;CSF1;CSF3;EFNA3;PIK3AP1;CHAD;CSF1R |
COMP has several biochemical functions, for example, calcium ion binding, collagen binding, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by COMP itself. We selected most functions COMP had, and list some proteins which have the same functions with COMP. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
calcium ion binding | GPD2;FBLN7;PCDHGC4;MEGF6;LRP1;SMOC2;MYL2B;ANXA2A;MMP1A |
collagen binding | MMP13;LUM;CTSL1;TLL1;CCBE1;ADAM9;SERPINH2;C1QTNF1;CTSB |
extracellular matrix structural constituent | COMP;MATN3;COL4A5;COL5A3B;KAL1;COL3A1;LUM;COL4A1;LAMA4 |
heparan sulfate proteoglycan binding | ITGAM;COMP;AGRN;HRG;SEMA5A;AZU1;PLA2G2D;GPC4;GPC1B |
heparin binding | PCOLCE;GPNMB;RSPO4;C6orf25;FGFR2;AZU1;NRP1;PRELP;LIPI |
protease binding | FN1;SERPINF2;TIMP2A;SELL;DPP4;ITGA3;TTN;TIMP2B;IL1R1 |
protein binding | TRDN;UBE2L3;FAM81B;CCNB1IP1;TFB1M;ORAI2;SDHA;PTPN2;KCNH7 |
COMP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COMP here. Most of them are supplied by our site. Hope this information will be useful for your research of COMP.
ADAMTS12; OTX1; MATN3; ACAN; ADAMTS7
- Q&As
- Reviews
Q&As (5)
Ask a questionCOMP levels are typically assessed through blood tests or synovial fluid analysis.
Yes, while COMP levels are indicative of joint diseases, they are often used alongside other diagnostic tools for a comprehensive assessment.
Monitoring changes in COMP levels can be valuable in assessing the effectiveness of treatments targeting joint diseases.
Given its involvement in joint diseases, COMP might be a target for drug development, but this area requires further exploration.
Elevated COMP levels often correlate with more rapid disease progression in arthritis, aiding in prognosis.
Customer Reviews (3)
Write a reviewOne of the standout factors that distinguishes the COMP protein is the manufacturer's unwavering commitment to exceptional technical support.
Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the COMP protein is an invaluable tool for researchers.
The COMP protein offers exceptional quality that meets the rigorous demands of experimental research.
Ask a Question for All COMP Products
Required fields are marked with *
My Review for All COMP Products
Required fields are marked with *