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COMP

  • Official Full Name

    cartilage oligomeric matrix protein

  • Overview

    Cartilage oligomeric matrix protein is a protein that in humans is encoded by the COMP gene. The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED)
  • Synonyms

    COMP; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , EDM1, EPD1, PSACH; MED; THBS5; thrombospondin 5; TSP5; thrombospondin-5; pseudoachondroplasia (epiphyseal dysplasia 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bacillus subtilis
  • Human
  • Mouse
  • Rat
  • CHO
  • E. coli or Yeast
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COMP-3659H Recombinant Human COMP protein, FLAG-tagged HEK293 Flag 750 AA
Human COMP-5794H Recombinant Human COMP protein, His & T7-tagged E.coli His/T7 Ser123~His240 (Accession # P49747)
Human COMP-3658H Recombinant Human COMP, His-tagged CHO His
Human COMP-11451H Recombinant Human COMP, GST-tagged E.coli GST 407-757a.a.
Human COMP-674H Active Recombinant Human COMP protein(Met1-Ala757), His-tagged HEK293 C-His Met1-Ala757
Human COMP-675H Recombinant Human COMP protein, His-tagged HEK293 His 737
Human COMP-1687H Recombinant Human COMP Protein, GST-tagged Wheat Germ GST
Human COMP-26251TH Recombinant Human COMP, FLAG-tagged HEK293 Flag 737 amino acids
Human COMP-3031HCL Recombinant Human COMP cell lysate Human Cell N/A
Human COMP-01H Recombinant Human COMP Protein, His-tagged HEK293 His
Human COMP-566H Recombinant Human COMP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human COMP-3183H Recombinant Human COMP protein, His-tagged E.coli His 35-257 aa
Human COMP-1947HF Recombinant Full Length Human COMP Protein, GST-tagged In Vitro Cell Free System GST 130 amino acids
Human COMP-185H Recombinant Human COMP Protein, His-tagged HEK293 His 757
Human COMP-1777H Recombinant Human COMP Protein (Ser123-His240), N-His tagged E.coli N-His Ser123-His240
Mouse COMP-3770M Recombinant Mouse COMP Protein Mammalian Cell His
Mouse Comp-5795M Recombinant Mouse Comp protein, His-tagged E.coli His Gln554~Gln753 (Accession # Q9R0G6)
Mouse COMP-1879M-B Recombinant Mouse COMP Protein Pre-coupled Magnetic Beads HEK293
Mouse COMP-1879M Recombinant Mouse COMP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Comp-921M Recombinant Mouse Comp Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat COMP-1528R Recombinant Rat COMP Protein Mammalian Cell His
Rat Comp-5796R Recombinant Rat Comp protein, His-tagged E.coli His Arg35~Ile179 (Accession # P35444)
Rat Comp-5797R Recombinant Rat Comp protein, His-tagged E.coli His Cys235~Phe423 (Accession # P35444)
Rat COMP-1185R-B Recombinant Rat COMP Protein Pre-coupled Magnetic Beads HEK293
Rat COMP-1185R Recombinant Rat COMP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Comp-825R Recombinant Rat Comp Protein, His-tagged E.coli N-His Arg35-Phe423
Bacillus subtilis COMP-0393B Recombinant Bacillus subtilis COMP protein, His-tagged E. coli or Yeast His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COMP Related Articles
  • COMP Related Research Area

COMP involved in several pathways and played different roles in them. We selected most pathways COMP participated on our site, such as ECM proteoglycans, ECM-receptor interaction, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with COMP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM proteoglycansLRP4;BGNB;PTPRS;MATN1;COL9A1;FMOD;BGNA;SPARC;COMP
ECM-receptor interactionTHBS3A;Reln;VTN;CD44;VTNA;ITGB7;IBSP;ITGA4;COL4A5
Extracellular matrix organizationCOL23A1;PCOLCE;DAG1;BMP10;PPIB;TIMP2A;MMP17;MATN3B;BMP1A
Focal AdhesionPDGFAA;ITGB4;ITGB7;PPP1R12C;MYL9;LAMA5;ROCK1;CDC42;PARVAA
Integrin cell surface interactionsCOL13A1;BSG;FBN1;LOC100514666;COMP;COL23A1;COL16A1;F11R.2;COL9A1B
MalariaHBB-B2;TGFB1;HBA2;IL1B;DARC;TGFB3;VCAM1;TNF;MET
PI3K-Akt signaling pathwayCSH;EFNA2;LOC608458;CSF1;CSF3;EFNA3;PIK3AP1;CHAD;CSF1R

COMP has several biochemical functions, for example, calcium ion binding, collagen binding, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by COMP itself. We selected most functions COMP had, and list some proteins which have the same functions with COMP. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingGPD2;FBLN7;PCDHGC4;MEGF6;LRP1;SMOC2;MYL2B;ANXA2A;MMP1A
collagen bindingMMP13;LUM;CTSL1;TLL1;CCBE1;ADAM9;SERPINH2;C1QTNF1;CTSB
extracellular matrix structural constituentCOMP;MATN3;COL4A5;COL5A3B;KAL1;COL3A1;LUM;COL4A1;LAMA4
heparan sulfate proteoglycan bindingITGAM;COMP;AGRN;HRG;SEMA5A;AZU1;PLA2G2D;GPC4;GPC1B
heparin bindingPCOLCE;GPNMB;RSPO4;C6orf25;FGFR2;AZU1;NRP1;PRELP;LIPI
protease bindingFN1;SERPINF2;TIMP2A;SELL;DPP4;ITGA3;TTN;TIMP2B;IL1R1
protein bindingTRDN;UBE2L3;FAM81B;CCNB1IP1;TFB1M;ORAI2;SDHA;PTPN2;KCNH7

COMP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COMP here. Most of them are supplied by our site. Hope this information will be useful for your research of COMP.

ADAMTS12; OTX1; MATN3; ACAN; ADAMTS7

Stanton, GB; Kohler, SJ; et al. Cytogenesis in the Adult Monkey Motor Cortex: Perivascular NG2 Cells Are the Major Adult Born Cell Type. JOURNAL OF COMPARATIVE NEUROLOGY 523:849-868(2015).
Butz, E; Peichl, L; et al. Cone Bipolar Cells in the Retina of the Microbat Carollia perspicillata. JOURNAL OF COMPARATIVE NEUROLOGY 523:963-981(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How are COMP protein levels measured in clinical settings? 11/02/2021

COMP levels are typically assessed through blood tests or synovial fluid analysis.

Are there limitations in using COMP levels as a standalone diagnostic tool? 11/24/2020

Yes, while COMP levels are indicative of joint diseases, they are often used alongside other diagnostic tools for a comprehensive assessment.

Can COMP levels be used to monitor treatment effectiveness? 10/14/2020

Monitoring changes in COMP levels can be valuable in assessing the effectiveness of treatments targeting joint diseases.

Can COMP protein be a potential target for future drug development? 11/26/2017

Given its involvement in joint diseases, COMP might be a target for drug development, but this area requires further exploration.

Can COMP levels predict disease progression in arthritis? 06/13/2017

Elevated COMP levels often correlate with more rapid disease progression in arthritis, aiding in prognosis.

Customer Reviews (3)

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Reviews
03/26/2021

    One of the standout factors that distinguishes the COMP protein is the manufacturer's unwavering commitment to exceptional technical support.

    01/15/2021

      Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the COMP protein is an invaluable tool for researchers.

      06/15/2017

        The COMP protein offers exceptional quality that meets the rigorous demands of experimental research.

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