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COMT

  • Official Full Name

    catechol-O-methyltransferase

  • Overview

    Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
  • Synonyms

    COMT; catechol-O-methyltransferase; catechol O-methyltransferase; Catechol O methyltransferase; COMT_HUMAN; EC 2.1.1.6; OTTHUMP00000197748; OTTHUMP00000197749; OTTHUMP00000197750; OTTHUMP00000197751; OTTHUMP00000197846; OTTHUMP00000198331;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Baculovirus-Insect Cells
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • SUMOpro
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COMT-1707H Active Recombinant Human COMT Protein, His-tagged E.coli His
Human COMT-26252TH Recombinant Human COMT, His-tagged E.coli His
Human COMT-126H Recombinant Human Catechol-O-methyltransferase, His-tagged E.coli His
Human COMT-1253H Recombinant Human Catechol-O-Methyltransferase Human N/A
Human COMT-1688H Recombinant Human COMT Protein, GST-tagged Wheat Germ GST
Human COMT-27960TH Recombinant Human COMT E.coli N/A 221 amino acids
Human COMT-7365HCL Recombinant Human COMT 293 Cell Lysate HEK293 N/A
Human COMT-1779H Recombinant Human COMT Protein (Gly52-Pro271), N-His tagged E.coli N-His Gly52-Pro271
Human COMT-3037H Recombinant Human COMT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human COMT-543H Recombinant Human COMT Protein (Met51-Pro271) E.coli N/A Met51-Pro271
Human COMT-1948HF Recombinant Full Length Human COMT Protein, GST-tagged In Vitro Cell Free System GST 182 amino acids
Human COMT-015H Recombinant Human COMT Protein, His/SUMO-tagged E.coli His/SUMO 2-221
Human COMT-542H Recombinant Human COMT protein (Met51-Pro271), His-tagged Baculovirus-Insect Cells His
Human COMT-4987H Recombinant Human COMT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human COMT-541H Recombinant Human COMT protein(Met1-Pro271), His-tagged Insect Cells C-His Met1-Pro271
Human COMT-088H Recombinant Human COMT protein, GST-tagged E. coli GST 1-182 aa
Human COMT-826H Recombinant Human COMT Protein, His-tagged E.coli N-His Gly52-Pro271
Human COMT-021H Recombinant Human COMT Protein, His/SUMOpro-tagged E. coli His/SUMOpro 2-221
Human COMT-827H Recombinant Human COMT Protein, His&GST-tagged E.coli N-His&GST Arg27-Pro271
Mouse COMT-3771M Recombinant Mouse COMT Protein Mammalian Cell His
Mouse Comt-922M Recombinant Mouse Comt Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Comt-828M Recombinant Mouse Comt Protein, His-tagged E.coli N-His Arg20-Ser265
Mouse COMT-1880M-B Recombinant Mouse COMT Protein Pre-coupled Magnetic Beads HEK293
Mouse COMT-1880M Recombinant Mouse COMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Comt-1670M Recombinant Mouse Comt protein, His-tagged E.coli His Gly63~Ser265 (Accession # O88587)
Rat Comt-829R Recombinant Rat Comt Protein, His-tagged E.coli N-His Arg20-Ser264
Rat Comt-1671R Recombinant Rat Comt protein, His-tagged E.coli His Gly63~Ser264
Bos taurus (Bovine) RFL13299BF Recombinant Full Length Bovine Catechol O-Methyltransferase(Comt) Protein, His-Tagged E.coli expression system His Full Length (1-272)
Homo sapiens (Human) RFL28387HF Recombinant Full Length Human Catechol O-Methyltransferase(Comt) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Mus musculus (Mouse) RFL33104MF Recombinant Full Length Mouse Catechol O-Methyltransferase(Comt) Protein, His-Tagged E.coli expression system His Full Length (1-265)
Rattus norvegicus (Rat) RFL11362RF Recombinant Full Length Rat Catechol O-Methyltransferase(Comt) Protein, His-Tagged E.coli expression system His Full Length (1-264)
Rhesus Macaque COMT-968R Recombinant Rhesus monkey COMT Protein, His-tagged Mammalian Cell His
Rhesus Macaque COMT-793R Recombinant Rhesus Macaque COMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque COMT-793R-B Recombinant Rhesus Macaque COMT Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COMT Related Articles
  • COMT Related Research Area

COMT involved in several pathways and played different roles in them. We selected most pathways COMT participated on our site, such as Biogenic Amine Synthesis, Biological oxidations, Dopamine clearance from the synaptic cleft, which may be useful for your reference. Also, other proteins which involved in the same pathway with COMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biogenic Amine SynthesisDBH;DDC;COMT;CHAT
Biological oxidationsCYP2U1;CYP11B1;MTRR;FDX1;AKR1A1;CYP2K22;ADH8B;ABHD10;SLC35B3
Dopamine clearance from the synaptic cleft
Dopamine metabolismDDC;NQO1;COMT
Dopaminergic synapseGNG7;KIF5B;MAPK13;CREB3L4;PPP2R3A;AKT2;GRIN2B;PRKCA;ATF6B
Enzymatic degradation of Dopamine by monoamine oxidase
Enzymatic degradation of dopamine by COMT
Estrogen metabolismCYP1A1;NQO1;CYP1B1;COMT;ARSE;ARSD

COMT has several biochemical functions, for example, O-methyltransferase activity, catechol O-methyltransferase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COMT itself. We selected most functions COMT had, and list some proteins which have the same functions with COMT. You can find most of the proteins on our site.

Function Related Protein
O-methyltransferase activityNDUFAF5;ASMT;BCDIN3D;TOMT;METTL21A;METTL21D;DIMT1;FAM86;COMTA
catechol O-methyltransferase activityCOMTB;COMTA;TOMT;COMT
magnesium ion bindingITPK1;SNRK;TDP2B;ENO4;FIGNL1;ERN2;NT5C1B;TSSK4;IRAK3
protein bindingNUP85;TLR2;MMP15;MYL6B;SRA1;EFCAB4A;ARNTL;MYH11;CAPN3

COMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COMT here. Most of them are supplied by our site. Hope this information will be useful for your research of COMT.

TRIP13; vpr; MCC; RGS2; LITAF; XRN2; c9jaw5_human; FN1; 1C; COL1A2; FGF2; RIN1; USP6NL; PPA2; EXO1

Hartung, JE; Ciszek, BP; et al. beta(2)- and beta(3)-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. PAIN 155:1346-1355(2014).
Hu, ZY; Lausted, C; et al. Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity. THERANOSTICS 4:215-228(2014).
  • Q&As
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Customer Reviews (3)

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Reviews
07/06/2021

    Its purity, stability, and functionality make it an ideal choice for my research endeavors.

    09/16/2019

      The COMT protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.

      04/09/2016

        Manufacturers should ensure the consistency and quality of COMT protein products.

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