CPB2
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Official Full Name
carboxypeptidase B2 (plasma)
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Overview
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] -
Synonyms
CPB2; carboxypeptidase B2 (plasma); CPU; PCPB; TAFI; carboxypeptidase B2; carboxypeptidase R; carboxypeptidase B-like protein; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase B2 (plasma, carboxypeptidase U);
- Native Proteins
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Myc
- DDK
- GST
- His (Fc)
- Avi
- His|S
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CPB2-8517H | Active Native Human CPB2 | Human | N/A |
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| Human | CPB2-3210H | Recombinant Human CPB2 protein, His-tagged | HEK293 | His | Met1-Val423 | |
| Human | CPB2-606H | Recombinant Human CPB2 protein, His-tagged | E.coli | His | Glu138~Val423 (Accession # Q96IY4) |
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| Human | CPB2-1778H | Recombinant Human CPB2 Protein, GST-tagged | Wheat Germ | GST |
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| Human | CPB2-3906H | Recombinant Human Carboxypeptidase B2 (Plasma), His-tagged | Human | His |
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| Human | CPB2-2252HCL | Recombinant Human CPB2 cell lysate | Human Cell | N/A |
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| Human | CPB2-169H | Recombinant Human CPB2 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | C-Myc/DDK |
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| Human | CPB2-27270TH | Native Human CPB2 | N/A | 400 amino acids |
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| Human | CPB2-3301H | Recombinant Human CPB2 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | CPB2-2034HF | Recombinant Full Length Human CPB2 Protein, GST-tagged | In Vitro Cell Free System | GST | 423 amino acids |
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| Human | CPB2-1789H | Recombinant Human CPB2 Protein (Glu138-Val423), His tagged | E.coli | His | Glu138-Val423 |
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| Human | CPB2-1790H | Recombinant Human CPB2 Protein (Phe23-Val423), C-His tagged | Mammalian cells | C-His | Phe23-Val423 |
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| Mouse | Cpb2-2505M | Recombinant Mouse Cpb2 protein, His-tagged | HEK293 | His | Met1-Thr422 |
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| Mouse | Cpb2-608M | Recombinant Mouse Cpb2 protein, His & S-tagged | E.coli | His/S | Arg113~Thr422 (Accession # Q9JHH6) |
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| Mouse | Cpb2-607M | Recombinant Mouse Cpb2 protein, His & S-tagged | E.coli | His/S | His309~Asp374 (Accession # Q9JHH6) |
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| Mouse | Cpb2-609M | Recombinant Mouse Cpb2 protein, His & S-tagged | E.coli | His/S | Pro187~Lys327 (Accession # Q9JHH6) |
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| Mouse | CPB2-1710MCL | Recombinant Mouse CPB2 cell lysate | Human Cell | N/A |
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| Mouse | Cpb2-2285M | Recombinant Mouse Cpb2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | Cpb2-610R | Recombinant Rat Cpb2 protein, His-tagged | E.coli | His | Gly164~His417 (Accession # Q9EQV9) |
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| Rat | Cpb2-1140R | Recombinant Rat Cpb2 Protein, His-tagged | HEK293 | His |
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| Rat | CPB2-1564R | Recombinant Rat CPB2 Protein | Mammalian Cell | His |
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| Rat | CPB2-1221R | Recombinant Rat CPB2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | CPB2-1221R-B | Recombinant Rat CPB2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | CPB2-2863Z | Recombinant Zebrafish CPB2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- CPB2 Related Articles
- CPB2 Related Research Area
CPB2 involved in several pathways and played different roles in them. We selected most pathways CPB2 participated on our site, such as Complement and Coagulation Cascades, Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and Coagulation Cascades | MBL2;CFI;CPB2;CD59A;CD59;A2M;C6;SERPINA1;C1QA |
| Metabolism of Angiotensinogen to Angiotensins | CPB2;CMA1;GZMH;CTSG;CPB1;ACE;ATP6AP2;CPA3 |
| Metabolism of proteins | TRAPPC2L;DAD1;IGFBP5A;TUBA1B;TRAPPC6B;DNAJC19;ATPBD4;SPON1A;GALNT6 |
| Pancreatic secretion | PLA2G5;PNLIP;CPB1;CPA2;PLA2G12A;PLA2G3;ATP1A1;CLCA5;CELA2B |
| Peptide hormone metabolism | SLC30A8;CGB5;SLC30A5;DPP4;CPE;RAB27A;CMA1;CDX2;INHA |
| Protein digestion and absorption | ATP1A4;SLC7A8;ATP1B2;SLC38A2;SLC8A1;SLC15A1;ATP1A1;COL21A1;KCNJ13 |
CPB2 has several biochemical functions, for example, metallocarboxypeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPB2 itself. We selected most functions CPB2 had, and list some proteins which have the same functions with CPB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metallocarboxypeptidase activity | AGBL4;FOLH1;PEPD;CPD;CPA4;CPA2;CPB1;CPZ;AGBL5 |
| zinc ion binding | SETDB1A;CUL9;Shh;GTF2B;THRA;RBM10;USP45;MICALL1;OTUD7A |
CPB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPB2.
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