CREBBP
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Official Full Name
CREB binding protein
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Overview
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play -
Synonyms
CREBBP; CREB binding protein; CBP; RSTS; KAT3A; CREB-binding protein; EC 2.3.1.48; CREBB; OTTHUMP00000159801; Rubinstein-Taybi syndrome; RTS;
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CREBBP involved in several pathways and played different roles in them. We selected most pathways CREBBP participated on our site, such as Activation of gene expression by SREBF (SREBP), Adherens junction, Androgen receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREBBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Activation of gene expression by SREBF (SREBP) | SREBF2;CARM1;PMVK;NFYBB;NFYAL;HELZ2;CREBBP;CYP51A1;DHCR7 |
Adherens junction | NLK;SSX2IP;RAC1;ERBB2;ACTB2;SSX2IPA;SNAI1;RHOAA;WASL |
Androgen receptor signaling pathway | DSTN;KAT7B;RAD9A;HTATIP;ETV5A;CARM1;PSMC3IP;CDKN1A;MYST2 |
Angiogenesis | CREBBP;TIMP2 |
Attenuation phase | CREBBP;HSBP1;PTGES3;HSBP1A;HSBP1B |
BMAL1:CLOCK,NPAS2 activates circadian gene expression | CREBBP;HELZ2;CRY2;NAMPT;CRY1;NCOA2;CARM1;DBP;NRIP1 |
C-MYB transcription factor network | ADA;TRIM28;SMARCA2;MYF6;ADORA2B;MYOD1;CDKN1B;CDK6;ELANE |
C-type lectin receptors (CLRs) | AHCYL1;CLEC4D;TAB1;MALT1;CREBBP;ITPR2;CLEC4A;CLEC6A;IL1B2 |
CREBBP has several biochemical functions, for example, MRF binding, RNA polymerase II activating transcription factor binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREBBP itself. We selected most functions CREBBP had, and list some proteins which have the same functions with CREBBP. You can find most of the proteins on our site.
Function | Related Protein |
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MRF binding | BHLHE40;CREBBP;KDM1A;TSC22D3 |
RNA polymerase II activating transcription factor binding | TBX3;CTNNB1;NEUROD1;RB1;NHLH2;HNF4A;SMAD3;TBX20;LDB1 |
RNA polymerase II regulatory region sequence-specific DNA binding | RXRB;NHLH2;ZNF711;NEUROD2;GATA6;HES6;ESRRG;GATA1;STAT4 |
RNA polymerase II transcription coactivator activity | SMARCA2;WBP2;PITX2;SOX4;NEUROD1;CITED4;POU3F1;CITED1;SOX11 |
RNA polymerase II transcription factor binding | GATA2A;GATA1A;SFPI1;ID4;SMAD4;TOX2;XBP1;MKX;GSC |
SMAD binding | SMAD2;BMPR1A;SKI;PRDM16;SNW1;ACVRL1;USP15;BMP2;COL1A2 |
acetyltransferase activity | KAT8;AANAT2;LPCAT3;CML2;EP300;NAT14;HHAT;MBOAT1;KAT5 |
chromatin binding | FLI1;CITED2;C10orf119;ZKSCAN3;SMARCD3;ASCL1;HMGXB4A;TCF3;ENY2 |
core promoter proximal region sequence-specific DNA binding | DMRTC2;KLF1;DMRTC1C2;DMRTA2;SP3A;DMRT2A;MEF2C;DMRT2;DMRT2B |
damaged DNA binding | CREBBP;GTF2H3;TP73;BRCA1;MGMT;RAD1;XRCC5;TRPC2;PCNA |
histone acetyltransferase activity | GTF3C4;HTATIP;NCOA1;KAT7;KAT8;TAF1;MED24;CDYL;MGEA5 |
p53 binding | TRIM24;RNF34;EHMT1;MAPKAPK5;EP300;AXIN1;KDM1A;BCL2L12;PLK3 |
peroxisome proliferator activated receptor binding | NFATC4;NR0B2;PPARGC1A;IKBKG;EP300;CREBBP;MED1;PRMT2;ASXL1 |
protein binding | SPDL1;TUBG1;FNDC3B;LRPPRC;CCT3;THAP10;TTC30B;OSTC;Shh |
signal transducer activity | PRLH2R;GPR132B;TAAR12B;AVP;CXCR2;HTR5AL;TAAR1B;PTGER1C;CXCR7B |
transcription coactivator activity | TAF10;SERTAD2;HINFP;GTF2F1;YAF2;KAT2A;ASXL1;TRIM24;TAF12 |
contributes_to transcription coactivator activity | ARID5B;PHF2;EP300;CREBBP |
transcription factor activity, sequence-specific DNA binding | STAT1A;POU3F2A;ZFP583;HSF4;MYBL2;E4F1;ATF7B;FLI1;BCL3 |
transcription factor binding | TFDP1;DRG1;PELP1;PARD6A;IFI16;MED1;RNF4;FIGLA;TAF1 |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MAFB;AIRE;NR1I2;RXRB;CSRNP3;ATF1;CSRNP2;BARX2;STAG1 |
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | JDP2;TCF3;DLX4;SNAI1;CTCF;HOXA2;HES1;ATF7;MYPOP |
transcriptional repressor activity, RNA polymerase II transcription factor binding | AHRR;CREBBP;MLIP;ELP2;PITX2;AHRRB;TBX6;EOMES;BHLHE40 |
zinc ion binding | TAB3;MARCH1;RFPL1;VPS8;ZNF259;TRIM8;PRICKLE2A;IDE;TRAF4 |
CREBBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREBBP here. Most of them are supplied by our site. Hope this information will be useful for your research of CREBBP.
TP53; e1a_ade12; IRF3; RELA
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Q&As (7)
Ask a questionDiscovering novel CREBBP inhibitors is crucial due to the limited number of reported inhibitors, and there is a need to enhance the activity and selectivity of existing compounds.
The bromodomain in CREBBP is linked to its involvement in cancer and other disease processes.
CREBBP stands for CREB-binding protein.
CREBBP serves as a coactivator for the cAMP response element-binding protein (CREB) transcription factor. It plays a crucial role in gene activation.
Research on small molecule inhibitors of CREBBP is in its early stages, with only a few inhibitors reported. Improvements in activity and selectivity are needed for these compounds.
CREBBP belongs to the third category of structural domain proteins, and it shares homology with its counterpart EP300.
CREBBP contains a bromodomain, which is associated with the development of cancer and other diseases.
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