CTGF
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Official Full Name
connective tissue growth factor
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Overview
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009] -
Synonyms
CTGF; connective tissue growth factor; CCN2; NOV2; HCS24; IGFBP8; IBP-8; IGFBP-8; CCN family member 2; IGF-binding protein 8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Rhesus macaque
- Sheep
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Protein Conjugation
- Sf9 Insect Cell
- Wheat Germ
- C
- Fc
- His
- DDK
- GST
- His (Fc)
- Avi
- His|Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CTGF Related Articles
- CTGF Related Research Area
CTGF involved in several pathways and played different roles in them. We selected most pathways CTGF participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty acid, triacylglycerol, and ketone body metabolism | DGAT1B;ACOT8;ACOT11B;ACOT2;CCNC;MED23;ACOT6;ACOT9.2;MED18 |
Gene Expression | SUPT5H;SKI;NFIA;TNPO1;TSEN34;HNRNPUL1;ZNF157;ZNF791;CBX3A |
Generic Transcription Pathway | NR1H3;ZNF529;ZNF750;COX14;ZNF92;TEAD3B;ZNF167;ZNF624;ZNF230 |
Hippo signaling pathway | FZD9;SNAI2;BMPR2;PPP1CB;PPP2R1B;PARD6B;LLGL1;TGFBR1;GDF5 |
Metabolism | YAP1;GNG13A;FAAH2B;CERS4A;SLC25A32B;SLC26A1;TYMP;CYP2K17;CYP3A7 |
Metabolism of lipids and lipoproteins | HSD17B11;SLC44A5B;YY2;LPA;APOA4B.2;ARF3;THEM5;ACSF3;ALOX5AP |
PPARA activates gene expression | MED26;APOA5;MED23;MED21;MED9;MED25;MTF1;CDK19;MED29 |
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | GRHL1;MED10;GLIPR1;MED18;PLIN2;MED16;MED26;MED20;MED6 |
CTGF has several biochemical functions, for example, fibronectin binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTGF itself. We selected most functions CTGF had, and list some proteins which have the same functions with CTGF. You can find most of the proteins on our site.
Function | Related Protein |
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fibronectin binding | CCDC80;CTGF;VEGFA;IGFBP3;SFRP2;CTSS;ITGB3;SDC4;IGFBP5B |
growth factor activity | LACRT;TGFB1;NGF;MANF;LFT2;VEGFA;GDF6;LIF;MIA1 |
heparin binding | RSPO4;WISP1A;VEGFAA;CXCL10;MMP7;CCL15;VEGFA;CTSG;CCL2 |
insulin-like growth factor binding | HTRA1A;IGFBP1A;DEFB126;IGF1RA;IGF2R;IGFBP2B;IGFBP5A;ESM1;WISP1 |
integrin binding | COL4A3;ADAM22;ESM1;ADAMTS5;ACTN1;CALR;LAMB1;MFGE8;JAM3 |
protein C-terminus binding | BCAM;VGLL3;ABL1;DLG1;SCLT1;SIRT1;PRDX3;BCL10;ATP1B1 |
protein binding | PRPS2;RPN1;SNAI1;LOX;CETN3;KHDC3;FHL2;AKAP6;SPRR2E |
CTGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTGF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTGF.
FN1; FGFR1OP; FGFR2; FGFR3; LIMS1; q81kk8_bacan; lonB; q81tk4_bacan; rpoB; gnd; nemA; mdtB; rnhA; q9wmx2-pro_0000037548; ITGA5
- Q&As
- Reviews
Q&As (5)
Ask a questionCTGF levels can be measured using various techniques, including enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry.
CTGF levels can serve as diagnostic markers for fibrotic diseases, aiding in the early detection and monitoring of such conditions.
Yes, targeting CTGF is being explored as a potential therapeutic strategy to mitigate fibrosis in various organs and tissues.
CTGF protein research is particularly relevant in specialties such as rheumatology, pulmonology, and dermatology due to its implications in fibrotic diseases.
CTGF plays a crucial role in promoting the formation of fibrous tissue by stimulating the production of extracellular matrix proteins.
Customer Reviews (3)
Write a reviewIts purity, stability, and consistency ensure reliable and reproducible results, giving me confidence in the integrity of my research findings.
With their assistance, I can overcome obstacles and optimize my experimental setup.
With the CTGF protein and the manufacturer's support, I am confident in obtaining accurate and meaningful results for my scientific investigations.
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