Ctsc
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Official Full Name
cathepsin C
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Overview
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CTSC; cathepsin C; PALS, PLS; dipeptidyl peptidase 1; DPP1; AI047818; CATC; Cathepsin J; CPPI; Dipeptidyl transferase; DPP I; DPPI; EC 3.4.14.1; HMS; JP; JPD; MGC126959; PALS; PLS; dipeptidyl peptidase I; dipeptidyl-peptidase I; DPP-I;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Ctsc Related Articles
- Ctsc Related Research Area
Ctsc involved in several pathways and played different roles in them. We selected most pathways Ctsc participated on our site, such as Adaptive Immune System, Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctsc were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | PPIAL4A;B2ML;FBXO17;DNM1;MICA;KIF4;CDKN1A;SPSB2;ARIH2 |
Asparagine N-linked glycosylation | TRAPPC3;GNE;SLC35A1;TRAPPC10;MGAT4A;ST8SIA3;MGAT4B;TFG;SCFD1 |
COPII (Coat Protein 2) Mediated Vesicle Transport | TRAPPC2L;TRAPPC6A;TRAPPC4;CSNK1D;USO1;TRAPPC2;CNIH3;AREG;GOLGA2 |
Cargo concentration in the ER | LMAN2L;MCFD2;CTSZ;SEC24A;AREG;SEC23A;LMAN2;CNIH3;CTSC |
ER to Golgi Anterograde Transport | CNIH3;NAPAB;TRAPPC6BL;TRAPPC3;SEC22C;SERPINA1L;PPP6C;TRAPPC6A;NAPG |
Immune System | ASB13;TRIM11;DEFA6;HAVCR2;CTLA4;TNFRSF13C;LY86;KIF3B;SUGT1 |
Lysosome | ATP6V0A2B;PSAPL1;AP3B1;ARSA;IGF2R;FUCA1;CTSSB.1;CTSBA;AP1G2 |
MHC class II antigen presentation | KIF26A;CTSLL;CTSH;DYNC1I1;DCTN6;FAM49BA;MGC174155;CTS7;KIF3B |
Ctsc has several biochemical functions, for example, chaperone binding, chloride ion binding, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctsc itself. We selected most functions Ctsc had, and list some proteins which have the same functions with Ctsc. You can find most of the proteins on our site.
Function | Related Protein |
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chaperone binding | DNAJB5;DNAJA3A;FGB;ST13;ERP29;TBCE;CALR;AHSA1L;DNAJB1 |
chloride ion binding | NLGN4X;SLC22A6;ACE;Amy1;AMY2A;CTSC |
cysteine-type endopeptidase activator activity involved in apoptotic process | GNB2L1;BAD;NLRP12;CASP1;CTSC;CTSH;MAPK9;BCL2L13;NLRP1 |
cysteine-type endopeptidase activity | USP13;CASP6L2;USP37;USP9X;USP15;MALT1A;UCHL1;USP4;CTSL2 |
cysteine-type peptidase activity | CAPN1B;CASP6L1;CTSLL;SENP7;CASPC;CAPN3A;USP43;OTUD7B;CAPN2A |
identical protein binding | RAD52;SMURF2;MTSS1;HSD17B10;GOT1L1;ACTB;MAP3K11;SMAD3;FHL2 |
phosphatase binding | SPRED1;KIAA0649;CNST;DZIP3;DLG3;PPP1R18;SH3YL1;SMAD2;SLC9A3R2 |
protein binding | GYG1;CRYAB;ORMDL3;SYNGR1;SGOL2;COBRA1;GEMIN6;KAZN;MRPL13 |
protein self-association | PABPN1;LDB1;S100A7A;AGA;MALT1;TP53;TRIM32;ZSWIM2;PCSK9 |
serine-type endopeptidase activity | IMMP1L;CTSG;Acr;LPA;PRSS21;LOC780933;TPSAB1;KLK1B1;PRSS59.1 |
Ctsc has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctsc here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctsc.
CST7; q1hvd6_ebva8; q7cgu7_yerpe; pepS; tal1; nrdB; nemA; gcvP; Bub1; Ktn1; Nek2; FGFR1OP; Tuba3a; MAPK8; Smo; G3BP1; SGOL1; Ppp2r1a
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