Ctsd
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Official Full Name
cathepsin D
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Overview
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008] -
Synonyms
CTSD; cathepsin D; CPSD; CLN10; HEL-S-130P; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P;
- Recombinant Proteins
- Native Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Antibody
- Assay Kits
- Chicken
- Cricetulus Griseus
- Cynomolgus
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293F
- Human Cell
- Human liver
- Human Liver
- Human Plasma
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Rabbit
- Wheat Germ
- C
- His
- GST
- GST|His
- His (Fc)
- Avi
- His|GST
- His|SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Ctsd Related Research Area
Ctsd involved in several pathways and played different roles in them. We selected most pathways Ctsd participated on our site, such as Adaptive Immune System, Ceramide signaling pathway, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctsd were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | KIF2A;RACGAP1;LILRA3;CTSH;ASB3;CXADR;MGC174155;MGC174152;FBXO3 |
Ceramide signaling pathway | CRADD;CTSD;EGF;PAWR;DERL3 |
Collagen degradation | ADAM10;MMP8;COL19A1;COL17A1;MGC174155;ELANE;MGC174152;CTSLL;CTSL1 |
Degradation of the extracellular matrix | ACAN;TPSAB1;BMP1A;TLL2;COL19A1;BMP1B;CTSD;MMP8;ADAMTS4 |
Direct p53 effectors | EDN2;AIFM2;TRIAP1;CD82;PCBP4;DUSP5;PPM1J;FDXR;HIC1 |
Extracellular matrix organization | COL16A1;CTSG;FURINB;COL6A3;DDR2;TIMP2;CTSK;COL15A1B;PPIB |
Immune System | LY86;MKRN1;CD300E;MGC174857;DUSP3;CXADR;FBXO27;ASB17;TRIM3 |
LKB1 signaling events | MARK4;MAP2;CDC37;CTSD;SIK3;STK11IP;MARK2 |
Ctsd has several biochemical functions, for example, aspartic-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctsd itself. We selected most functions Ctsd had, and list some proteins which have the same functions with Ctsd. You can find most of the proteins on our site.
Function | Related Protein |
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aspartic-type endopeptidase activity | PGA5;Ren1;PGC;NAPSA;PSEN2;CTSE;DDI2;NOTS;ATP6AP2 |
protein binding | RBPMS;RPL11;C10orf18;SMAP2;NCAM1A;FBXL19;PPP4R2;TIE1;JAM3B |
Ctsd has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctsd here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctsd.
env; APP; hly; HBA1; MAPK1; purT; q7cjw2_yerpe; leuD; RASSF10; ere_dna; RASSF9; cona_canen; H2AFX; VCAM1; ATP6V1A; RASSF7
- Q&As
- Reviews
Q&As (6)
Ask a questionThere is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.
In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.
For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.
It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.
People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.
CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.
Customer Reviews (3)
Write a reviewGood at western-blot experiments.
In experiments, the biocompatibility performed well.
The experimental conditions are broad, and the experimental results are accurate and repeatable.
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