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CTSH

  • Official Full Name

    cathepsin H

  • Overview

    The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors.
  • Synonyms

    CTSH; cathepsin H; CPSB; pro-cathepsin H; ACC 4; ACC 5; aleurain; cathepsin B3; cathepsin BA; N-benzoylarginine-beta-naphthylamide hydrolase; ACC-4; ACC-5; minichain; MGC1519; DKFZp686B24257;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human liver
  • Human Liver
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTSH-478H Active Recombinant Human CTSH, His-tagged CHO His
Human CTSH-190H Active Native Human Cathepsin H Human Liver N/A
Human CTSH-8180H Recombinant Human CTSH protein, His & T7-tagged E.coli His/T7 Ala23~Val335 (Accession # P09668)
Human CTSH-1650H Recombinant Human Cathepsin H Human liver N/A
Human CTSH-3042H Recombinant Human Cathepsin H, T7-tagged E.coli T7
Human CTSH-11688H Recombinant Human CTSH, GST-tagged E.coli GST 58-289a.a.
Human CTSH-2108H Recombinant Human CTSH Protein, GST-tagged Wheat Germ GST
Human CTSH-3371H Recombinant Human CTSH Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CTSH-360H Native Human Eosinophil Peroxidase Human Liver N/A
Human CTSH-27404TH Native Human CTSH N/A
Human CTSH-1619H Recombinant Human CTSH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CTSH-0261H Recombinant Human CTSH protein, His-tagged HEK293 His Ala23-Val335
Human CTSH-2352HF Recombinant Full Length Human CTSH Protein, GST-tagged In Vitro Cell Free System GST 335 amino acids
Human CTSH-1887H Recombinant Human CTSH Protein (Ala23-Val335), C-His tagged Mammalian cells C-His Ala23-Val335
Human CTSH-1889H Recombinant Human CTSH Protein (Ala23-Val335), N-His tagged E.coli N-His Ala23-Val335
Mouse Ctsh-8181M Recombinant Mouse Ctsh protein, His & T7-tagged E.coli His/T7 Ala21~Val333 (Accession # P49935)
Mouse Ctsh-481M Recombinant Mouse Ctsh, His-tagged Human Cell His Ala21-Val333
Mouse CTSH-001MCL Recombinant Mouse CTSH cell lysate Human Cell N/A
Mouse Ctsh-2370M Recombinant Mouse Ctsh Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ctsh-5638M Recombinant Mouse Ctsh Protein (Glu22-Val333), C-His tagged Mammalian cells C-His Glu22-Val333
Rat CTSH-1665R Recombinant Rat CTSH Protein Mammalian Cell His
Rat Ctsh-1292R Recombinant Rat Ctsh Protein, His-tagged E.coli N-His Ala21-Val333
Rat CTSH-1324R-B Recombinant Rat CTSH Protein Pre-coupled Magnetic Beads HEK293
Rat CTSH-1324R Recombinant Rat CTSH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CTSH-11964Z Recombinant Zebrafish CTSH Mammalian Cell His
Kit-2153 Cathepsin H Inhibitor Screening Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CTSH Related Articles
  • CTSH Related Research Area

CTSH involved in several pathways and played different roles in them. We selected most pathways CTSH participated on our site, such as Adaptive Immune System, Immune System, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemBLK;KLHL21;STUB1;KLRF1;AMICA1;DNM2;RBCK1;EGFR;KIF2A
Immune SystemMGC174857;TRIM10;VPRBP;SEC24A;GBP2;CLEC2B;EDARADD;TIRAP;CLEC6A
LysosomeATP6V0A1A;ARSG;ACP5A;ATP6V0D1;GNPTG;ATP6V1H;ASAH1;PPT2;AP3M1
MHC class II antigen presentationMGC174152;MGC174857;KLC3;KIFAP3;KIF15;IFI30;KIF3B;DYNC1LI2;OSBPL1A
Metabolism of proteinsALG14;FBXW5;PMPCB;YY2;FURINB;SLC38A8;CBX8;WIPI1;NAT8
Surfactant metabolismCTSH;GATA6;CKAP4;GPR116;SLC34A2A;SFTPC;LMCD1;CCDC59;DMBT1

CTSH has several biochemical functions, for example, HLA-A specific activating MHC class I receptor activity, aminopeptidase activity, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSH itself. We selected most functions CTSH had, and list some proteins which have the same functions with CTSH. You can find most of the proteins on our site.

Function Related Protein
HLA-A specific activating MHC class I receptor activity
aminopeptidase activityXPNPEP3;Npepo;TRHDE;METAP1;DPP9;LAP3;PHEX;CTSL2;LNPEP
cysteine-type endopeptidase activator activity involved in apoptotic processBAD;CTSH;CTSC;APAF1;RPS27L;CARD8;NLRP1;MAPK9;CASP1
cysteine-type endopeptidase activityATG4A;USP51;CTSSB.2;CTSLA;CTSO;USP31;DUB1;USP2;CTSS
cysteine-type peptidase activityCTSJ;USP2A;CASP3A;CAPN2L;CAPN3;CTSL1;CTSSB.1;CTLA2B;CAPN3A
endopeptidase activityFAP;SENP1;TPP1;PSMA6B;PSMB7;TPP2;SENP3A;PSMB8F;ADAMTS3
peptidase activityPARK7;PRSS59.1;Adamts19;TMPRSS4A;CASPA;CAPN11;ZMPSTE24;USP25;CAPN3B
protein bindingMLANA;HSPB11;WNT3;SNRPE;BBS5;SGIP1;RABGGTB;TMEM203;VANGL1
serine-type endopeptidase activityTMPRSS4B;PRSS30;PLG;MMP2;C1R;GZME;PRSS22;KEX2;TYSND1
thyroid hormone bindingCTSH;CRYM;THRA;THRB;ALDH1A3

CTSH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSH here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSH.

VCAM1

Mahlios, J; De la Herran-Arita, AK; et al. The autoimmune basis of narcolepsy. CURRENT OPINION IN NEUROBIOLOGY 23:767-773(2013).
Kiyamova, R; Garifulin, O; et al. Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers. BIOMARKERS 17:362-371(2012).
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