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Ctsz

  • Official Full Name

    cathepsin Z

  • Overview

    The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis.
  • Synonyms

    CTSZ; cathepsin Z; Cathepsin P; Cathepsin X; Cathepsin X precursor; Cathepsin Z precursor; CathepsinP; CathepsinX; CathepsinZ; CATZ_HUMAN; CTSX; FLJ17088; Preprocathepsin P; PreprocathepsinP; OTTHUMP00000031409;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTSZ-191H Active Recombinant Human CTSZ Protein, His-tagged HEK293 His
Human CTSZ-406H Recombinant Human Cathepsin Z Mammalian cells N/A
Human CTSZ-27236TH Recombinant Human CTSZ Wheat Germ N/A 303 amino acids
Human CTSZ-2120H Recombinant Human CTSZ Protein, GST-tagged Wheat Germ GST
Human CTSZ-2328H Recombinant Human CTSZ, His-tagged E.coli His 265aa
Human CTSZ-8185H Recombinant Human CTSZ protein, His & T7-tagged E.coli His/T7 Gly24~Val303 (Accession # Q9UBR2)
Human CTSZ-1603HCL Recombinant Human CTSZ cell lysate Human Cell N/A
Human CTSZ-658H Active Recombinant Human CTSZ Protein, His-tagged Insect Cell His 24-303 aa
Human CTSZ-0870H Recombinant Human CTSZ Protein (Gly24-Val303), C-His tagged Mammalian cells C-His Gly24-Val303
Human CTSZ-2085H Recombinant Human CTSZ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CTSZ-101HF Recombinant Full Length Human CTSZ Protein In Vitro Cell Free System 303 amino acids
Human CTSZ-2367HF Recombinant Full Length Human CTSZ Protein, GST-tagged In Vitro Cell Free System GST 303 amino acids
Human CTSZ-1896H Recombinant Human CTSZ Protein (Gly24-Val303), N-His tagged E.coli N-His Gly24-Val303
Human CTSZ-4385H-B Recombinant Human CTSZ Protein Pre-coupled Magnetic Beads HEK293
Human CTSZ-3386H Recombinant Human CTSZ Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CTSZ-4385H Recombinant Human CTSZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ctsz-8186M Recombinant Mouse Ctsz protein, His-tagged E.coli His Thr34~Tyr291
Mouse Ctsz-32M Recombinant Mouse Ctsz Protein, His-tagged Insect Cell His
Mouse Ctsz-283M Recombinant Mouse Ctsz, His tagged Human Cell His
Mouse CTSZ-3020MCL Recombinant Mouse CTSZ cell lysate Human Cell N/A
Mouse Ctsz-2371M Recombinant Mouse Ctsz Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ctsz-7406M Recombinant Mouse Ctsz Protein, His-tagged Insect Cell His 23-306
Zebrafish CTSZ-1557Z Recombinant Zebrafish CTSZ Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ctsz Related Articles
  • Ctsz Related Research Area

Ctsz involved in several pathways and played different roles in them. We selected most pathways Ctsz participated on our site, such as Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctsz were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Asparagine N-linked glycosylationTRAPPC3;TRAPPC6B;OS9;ANKRD28;SERPINA1L;CTAGE5;ST8SIA3;LMAN2L;NAPG
COPII (Coat Protein 2) Mediated Vesicle TransportNSFB;TRAPPC2L;CTSZ;TRAPPC6B;TRAPPC6BL;TRAPPC5;CSNK1D;TRAPPC1;BET1
Cargo concentration in the ERAREG;TMED2;SEC23A;CNIH;MIA3;SEC24A;PREB;LMAN2;CTSZ
Clathrin derived vesicle buddingSNX9;PICALMB;AP1M2;NECAP1;GAK;AP3S1;BLOC1S6;APPB;FTH1A
ER to Golgi Anterograde TransportSEC24A;GORASP1;MIA3;TFG;NSFA;SCFD1;CNIH2;TRAPPC6BL;TRAPPC6B
LysosomeCD68;GLA;SORT1;CLTCA;NAGA;SMPD1;GGA2;AP3B1;DNASE2B
Lysosome Vesicle BiogenesisBLOC1S1;CTSZ;DNASE2;AP1S3A;CLVS2;AP4B1;CLVS1
Membrane TraffickingDAB2;PICALMB;PREB;MYO1C;AP4B1;GJB7;TRAPPC6A;DNASE2;CNIH

Ctsz has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type peptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctsz itself. We selected most functions Ctsz had, and list some proteins which have the same functions with Ctsz. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase activityCTSL.1;CTSC;SFRP1;CTSO;USP34;USP50;CTSF;CASPBL;CTSZ
cysteine-type peptidase activityUSP17L1P;ESPL1;CTSSB.2;CTSM;CAPN2L;ATG4A;USP9X;ZRANB1B;CTSBB
protein bindingPIM1;ZFP523;MYO10;INPP5A;SLC9A3R1;TRIM11;SAP30;CFLAR;SMN1

Ctsz has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctsz here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctsz.

KRTAP5-9; PLSCR1; MTUS2; KRT40; NOTCH2NL; MID2; Kifc5b

Vazquez, R; Astorgues-Xerri, L; et al. Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors. BIOCHIMIE 108C:101-107(2015).
Lee, J; Kim, JH; et al. Novel cathepsin B and cathepsin B-like cysteine protease of Naegleria fowleri excretory-secretory proteins and their biochemical properties. PARASITOLOGY RESEARCH 113:2765-2776(2014).
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