CYBB
-
Official Full Name
cytochrome b-245, beta polypeptide
-
Overview
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cells respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008] -
Synonyms
CYBB; cytochrome b-245, beta polypeptide; CGD; NOX2; AMCBX2; GP91-1; GP91PHOX; p91-PHOX; GP91-PHOX; cytochrome b-245 heavy chain; CGD91-phox; NADPH oxidase 2; p22 phagocyte B-cytochrome; cytochrome b558 subunit beta; cytochrome b(558) subunit beta; neutrophil cytochrome b 91 kDa polypeptide; heme-binding membrane glycoprotein gp91phox; superoxide-generating NADPH oxidase heavy chain subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Bison bison (American bison) (Bos bison)
- Bos taurus (Bovine)
- Chicken
- Escherichia coli (strain K12)
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Shigella flexneri
- Sus scrofa (Pig)
- Yersinia pestis
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His|SUMO
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CYBB-30450TH | Recombinant Human CYBB | Wheat Germ | N/A | 52 amino acids | |
Human | CYBB-2222H | Recombinant Human CYBB Protein, GST-tagged | Wheat Germ | GST | ||
Human | CYBB-11752H | Recombinant Human CYBB, His-tagged | E.coli | His | 422-577a.a. | |
Human | CYBB-7138HCL | Recombinant Human CYBB 293 Cell Lysate | HEK293 | N/A | ||
Human | CYBB-443H | Recombinant Human CYBB Protein (283-570 aa), His-SUMO-tagged | E.coli | His/SUMO | 283-570 aa | |
Human | CYBB-2781H | Recombinant Human CYBB protein, His-tagged | E.coli | His | 283-570aa | |
Human | CYBB-2242H | Recombinant Human CYBB Protein (283-570 aa), His-tagged | Yeast | His | 283-570 aa | |
Bison bison (American bison) (Bos bison) | RFL17396BF | Recombinant Full Length Bison Bison Cytochrome B-245 Heavy Chain(Cybb) Protein, His-Tagged | E.coli expression system | His | Full Length (1-570) | |
Bos taurus (Bovine) | RFL28382BF | Recombinant Full Length Bovine Cytochrome B-245 Heavy Chain(Cybb) Protein, His-Tagged | E.coli expression system | His | Full Length (1-570) | |
Escherichia coli (strain K12) | RFL23151EF | Recombinant Full Length Escherichia Coli Cytochrome B561(Cybb) Protein, His-Tagged | E.coli expression system | His | Full Length (1-176) | |
Homo sapiens (Human) | RFL34907HF | Recombinant Full Length Human Cytochrome B-245 Heavy Chain(Cybb) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-570) | |
Mus musculus (Mouse) | RFL13821MF | Recombinant Full Length Mouse Cytochrome B-245 Heavy Chain(Cybb) Protein, His-Tagged | E.coli expression system | His | Full Length (1-570) | |
Shigella flexneri | RFL22992SF | Recombinant Full Length Cytochrome B561(Cybb) Protein, His-Tagged | E.coli expression system | His | Full Length (1-176) | |
Sus scrofa (Pig) | RFL12674SF | Recombinant Full Length Pig Cytochrome B-245 Heavy Chain(Cybb) Protein, His-Tagged | E.coli expression system | His | Full Length (1-484) | |
Yersinia pestis | RFL17126YF | Recombinant Full Length Probable Cytochrome B561(Cybb) Protein, His-Tagged | E.coli expression system | His | Full Length (1-176) | |
Zebrafish | CYBB-10725Z | Recombinant Zebrafish CYBB | Mammalian Cell | His | ||
Chicken | CYBB-3727C | Recombinant Chicken CYBB | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- CYBB Related Articles
CYBB involved in several pathways and played different roles in them. We selected most pathways CYBB participated on our site, such as Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing &, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYBB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Adaptive Immune System | FRS2A;AKR1C1;PJA2;CD226;CD200R1;GRAP2B;AGO1;STIM1B;SH3RF1 |
Antigen processing-Cross presentation | SEC61B;FCGR1B;CTSL1;CD207;CYBB;CYBA;CTSL2;CTSS |
Class I MHC mediated antigen processing & | ATG7;ASB8;SEC61B;BLMH;ASB7;SEC23A;STUB1;TRIM50;RNF14 |
presentation | MKRN1;CTSL1;SEC23A;WWP1;SEC61B;RNF41;WSB1;LRSAM1;CYBA |
Cross-presentation of particulate exogenous antigens (phagosomes) | CYBB;CYBA |
HIF-1 signaling pathway | EGLN2;AHA-1;EGLN3;CYBB |
Immune System | MGC174857;TRIM56;ADAR;GZMM;S100A12;HCST;IFIT2;ATG7;SIGLEC7 |
Leukocyte transendothelial migration | MYL9;CLDN18;ACTG1;MAPK11;PRKCB;CXCR4;PIK3CG;CLDN3;PRKCA |
Osteoclast differentiation | TREM2;SQSTM1;LILRB2;FOS;LILRB3;NCF4;PPP3R1;SFPI1;NFATC1 |
CYBB has several biochemical functions, for example, contributes_to electron carrier activity, flavin adenine dinucleotide binding, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYBB itself. We selected most functions CYBB had, and list some proteins which have the same functions with CYBB. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
contributes_to electron carrier activity | |
flavin adenine dinucleotide binding | ACADM;KMO;NDOR1;MAOB;DLDH;ACAD8;FMO1;DUS4L;MTHFR |
heme binding | CYGB;MPX;CYP2Y3;GUCY1B3;CYP2H1;HBB-BH1;CYP20A1;CYP2U1;CYP26B1 |
metal ion binding | PRDM8B;GNS;CAR3;ERI3;ZNF649;NEK5;ZIM3;MPO;RNF11B |
protein binding | CLIC5;RTKN;DDX11;PSME3;ADAM12;CCDC170;PGBD1;EDC4;EZR |
protein heterodimerization activity | AXL;KATNA1;UNC13A;UGT1A1;NPM1;ADORA2A;KCNK9;TLR2;YWHAE |
contributes_to superoxide-generating NADPH oxidase activity | CYBB;CYBA |
superoxide-generating NADPH oxidase activity | CYBB;NOX1;NOX5;NOX3;PAX2;SH3PXD2AA;NCF1;NOX4 |
voltage-gated ion channel activity | SCN8AB;CLIC5B;CLIC5A;KCNJ1A.6;KCNV2B;KCNK16;CX35B;CACNG8A;KCNG4A |
CYBB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYBB here. Most of them are supplied by our site. Hope this information will be useful for your research of CYBB.
RAC2
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All CYBB Products
Required fields are marked with *
My Review for All CYBB Products
Required fields are marked with *