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CYBB

  • Official Full Name

    cytochrome b-245, beta polypeptide

  • Overview

    Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cells respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
  • Synonyms

    CYBB; cytochrome b-245, beta polypeptide; CGD; NOX2; AMCBX2; GP91-1; GP91PHOX; p91-PHOX; GP91-PHOX; cytochrome b-245 heavy chain; CGD91-phox; NADPH oxidase 2; p22 phagocyte B-cytochrome; cytochrome b558 subunit beta; cytochrome b(558) subunit beta; neutrophil cytochrome b 91 kDa polypeptide; heme-binding membrane glycoprotein gp91phox; superoxide-generating NADPH oxidase heavy chain subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Bison bison (American bison) (Bos bison)
  • Bos taurus (Bovine)
  • Chicken
  • Escherichia coli (strain K12)
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Shigella flexneri
  • Sus scrofa (Pig)
  • Yersinia pestis
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYBB-30450TH Recombinant Human CYBB Wheat Germ N/A 52 amino acids
Human CYBB-2222H Recombinant Human CYBB Protein, GST-tagged Wheat Germ GST
Human CYBB-11752H Recombinant Human CYBB, His-tagged E.coli His 422-577a.a.
Human CYBB-7138HCL Recombinant Human CYBB 293 Cell Lysate HEK293 N/A
Human CYBB-443H Recombinant Human CYBB Protein (283-570 aa), His-SUMO-tagged E.coli His/SUMO 283-570 aa
Human CYBB-2781H Recombinant Human CYBB protein, His-tagged E.coli His 283-570aa
Human CYBB-2242H Recombinant Human CYBB Protein (283-570 aa), His-tagged Yeast His 283-570 aa
Bison bison (American bison) (Bos bison) RFL17396BF Recombinant Full Length Bison Bison Cytochrome B-245 Heavy Chain(Cybb) Protein, His-Tagged E.coli expression system His Full Length (1-570)
Bos taurus (Bovine) RFL28382BF Recombinant Full Length Bovine Cytochrome B-245 Heavy Chain(Cybb) Protein, His-Tagged E.coli expression system His Full Length (1-570)
Escherichia coli (strain K12) RFL23151EF Recombinant Full Length Escherichia Coli Cytochrome B561(Cybb) Protein, His-Tagged E.coli expression system His Full Length (1-176)
Homo sapiens (Human) RFL34907HF Recombinant Full Length Human Cytochrome B-245 Heavy Chain(Cybb) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-570)
Mus musculus (Mouse) RFL13821MF Recombinant Full Length Mouse Cytochrome B-245 Heavy Chain(Cybb) Protein, His-Tagged E.coli expression system His Full Length (1-570)
Shigella flexneri RFL22992SF Recombinant Full Length Cytochrome B561(Cybb) Protein, His-Tagged E.coli expression system His Full Length (1-176)
Sus scrofa (Pig) RFL12674SF Recombinant Full Length Pig Cytochrome B-245 Heavy Chain(Cybb) Protein, His-Tagged E.coli expression system His Full Length (1-484)
Yersinia pestis RFL17126YF Recombinant Full Length Probable Cytochrome B561(Cybb) Protein, His-Tagged E.coli expression system His Full Length (1-176)
Zebrafish CYBB-10725Z Recombinant Zebrafish CYBB Mammalian Cell His
Chicken CYBB-3727C Recombinant Chicken CYBB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYBB Related Articles

CYBB involved in several pathways and played different roles in them. We selected most pathways CYBB participated on our site, such as Adaptive Immune System, Antigen processing-Cross presentation, Class I MHC mediated antigen processing &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYBB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemFRS2A;AKR1C1;PJA2;CD226;CD200R1;GRAP2B;AGO1;STIM1B;SH3RF1
Antigen processing-Cross presentationSEC61B;FCGR1B;CTSL1;CD207;CYBB;CYBA;CTSL2;CTSS
Class I MHC mediated antigen processing &ampATG7;ASB8;SEC61B;BLMH;ASB7;SEC23A;STUB1;TRIM50;RNF14
presentationMKRN1;CTSL1;SEC23A;WWP1;SEC61B;RNF41;WSB1;LRSAM1;CYBA
Cross-presentation of particulate exogenous antigens (phagosomes)CYBB;CYBA
HIF-1 signaling pathwayEGLN2;AHA-1;EGLN3;CYBB
Immune SystemMGC174857;TRIM56;ADAR;GZMM;S100A12;HCST;IFIT2;ATG7;SIGLEC7
Leukocyte transendothelial migrationMYL9;CLDN18;ACTG1;MAPK11;PRKCB;CXCR4;PIK3CG;CLDN3;PRKCA
Osteoclast differentiationTREM2;SQSTM1;LILRB2;FOS;LILRB3;NCF4;PPP3R1;SFPI1;NFATC1

CYBB has several biochemical functions, for example, contributes_to electron carrier activity, flavin adenine dinucleotide binding, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYBB itself. We selected most functions CYBB had, and list some proteins which have the same functions with CYBB. You can find most of the proteins on our site.

Function Related Protein
contributes_to electron carrier activity
flavin adenine dinucleotide bindingACADM;KMO;NDOR1;MAOB;DLDH;ACAD8;FMO1;DUS4L;MTHFR
heme bindingCYGB;MPX;CYP2Y3;GUCY1B3;CYP2H1;HBB-BH1;CYP20A1;CYP2U1;CYP26B1
metal ion bindingPRDM8B;GNS;CAR3;ERI3;ZNF649;NEK5;ZIM3;MPO;RNF11B
protein bindingCLIC5;RTKN;DDX11;PSME3;ADAM12;CCDC170;PGBD1;EDC4;EZR
protein heterodimerization activityAXL;KATNA1;UNC13A;UGT1A1;NPM1;ADORA2A;KCNK9;TLR2;YWHAE
contributes_to superoxide-generating NADPH oxidase activityCYBB;CYBA
superoxide-generating NADPH oxidase activityCYBB;NOX1;NOX5;NOX3;PAX2;SH3PXD2AA;NCF1;NOX4
voltage-gated ion channel activitySCN8AB;CLIC5B;CLIC5A;KCNJ1A.6;KCNV2B;KCNK16;CX35B;CACNG8A;KCNG4A

CYBB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYBB here. Most of them are supplied by our site. Hope this information will be useful for your research of CYBB.

RAC2

Sonati, T; Reimann, RR; et al. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. NATURE 501:102-+(2013).
Lee, WI; Huang, JL; et al. Patients with inhibitory and neutralizing auto-antibodies to interferon-gamma resemble the sporadic adult-onset phenotype of Mendelian Susceptibility to. Mycobacterial Disease (MSMD) lacking Bacille Calmette-Guerin (BCG)-induced diseases. IMMUNOBIOLOGY 218:762-771(2013).
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