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DAD1

  • Official Full Name

    Defender Against Cell Death 1

  • Overview

    DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.
  • Synonyms

    OST2; DAD1; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Oligosaccharyl transferase subunit DAD1; EC=2.4.1.119; Defender against cell death 1; AD-1; OTTHUMP00000164488; OTTHUMP00000239715; OTTHUMP00000239717; DAD-1; dolichyl-diphosphooligosaccharide--protein glycosyltransfe-rase subunit DAD1; EC 2.4.1.119; oligosaccharyltransferase 2 homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Arabidopsis thaliana (Mouse-ear cress)
  • Araneus ventricosus (Orbweaver spider) (Epeira ventricosa)
  • Betula pendula (European white birch) (Betula verrucosa)
  • Bos taurus (Bovine)
  • Chicken
  • Citrus unshiu (Satsuma mandarin) (Citrus nobilis var. unshiu)
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Hordeum vulgare (Barley)
  • Human
  • Malus domestica (Apple) (Pyrus malus)
  • Mesocricetus auratus (Golden hamster)
  • Mus musculus (Mouse)
  • Oryza sativa subsp. indica (Rice)
  • Oryza sativa subsp. japonica (Rice)
  • Picea mariana (Black spruce) (Abies mariana)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
  • Sus scrofa (Pig)
  • Xenopus laevis (African clawed frog)
  • Zea mays (Maize)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DAD1-11817H Recombinant Human DAD1, GST-tagged E.coli GST 1-113a.a.
Human DAD1-2324H Recombinant Human DAD1 Protein, GST-tagged Wheat Germ GST
Human DAD1-27092TH Recombinant Human DAD1 Wheat Germ N/A 113 amino acids
Human DAD1-215HCL Recombinant Human DAD1 lysate HEK293 N/A
Human DAD1-2314HF Recombinant Full Length Human DAD1 Protein, GST-tagged In Vitro Cell Free System GST 113 amino acids
Human DAD1-120HF Recombinant Full Length Human DAD1 Protein In Vitro Cell Free System 113 amino acids
Rat DAD1-1769R Recombinant Rat DAD1 Protein Mammalian Cell His
Rat DAD1-1427R Recombinant Rat DAD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DAD1-1427R-B Recombinant Rat DAD1 Protein Pre-coupled Magnetic Beads HEK293
Arabidopsis thaliana (Mouse-ear cress) RFL33444AF Recombinant Full Length Arabidopsis Thaliana Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-115)
Araneus ventricosus (Orbweaver spider) (Epeira ventricosa) RFL6455AF Recombinant Full Length Araneus Ventricosus Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-113)
Betula pendula (European white birch) (Betula verrucosa) RFL3549BF Recombinant Full Length Betula Pendula Defender Against Cell Death 1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-115)
Bos taurus (Bovine) RFL30540BF Recombinant Full Length Bovine Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-113)
Citrus unshiu (Satsuma mandarin) (Citrus nobilis var. unshiu) RFL28983CF Recombinant Full Length Citrus Unshiu Defender Against Cell Death 1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-115)
Gallus gallus (Chicken) RFL3501GF Recombinant Full Length Chicken Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-123)
Homo sapiens (Human) RFL13931HF Recombinant Full Length Human Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-113)
Hordeum vulgare (Barley) RFL19595HF Recombinant Full Length Hordeum Vulgare Defender Against Cell Death 1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-114)
Malus domestica (Apple) (Pyrus malus) RFL34041MF Recombinant Full Length Malus Domestica Defender Against Cell Death 1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-119)
Mesocricetus auratus (Golden hamster) RFL5797MF Recombinant Full Length Mesocricetus Auratus Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-113)
Mus musculus (Mouse) RFL9898MF Recombinant Full Length Mouse Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-113)
Oryza sativa subsp. indica (Rice) RFL15066OF Recombinant Full Length Oryza Sativa Subsp. Indica Defender Against Cell Death 1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-114)
Oryza sativa subsp. japonica (Rice) RFL15734OF Recombinant Full Length Oryza Sativa Subsp. Japonica Defender Against Cell Death 1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-114)
Picea mariana (Black spruce) (Abies mariana) RFL32921PF Recombinant Full Length Picea Mariana Defender Against Cell Death 1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-115)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL4444PF Recombinant Full Length Pongo Abelii Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-113)
Rattus norvegicus (Rat) RFL16927RF Recombinant Full Length Rat Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-113)
Rhesus Macaque DAD1-1173R Recombinant Rhesus monkey DAD1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DAD1-998R Recombinant Rhesus Macaque DAD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DAD1-998R-B Recombinant Rhesus Macaque DAD1 Protein Pre-coupled Magnetic Beads HEK293
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) RFL2598SF Recombinant Full Length Solanum Lycopersicum Defender Against Cell Death 1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-116)
Sus scrofa (Pig) RFL26438SF Recombinant Full Length Pig Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-113)
Xenopus laevis (African clawed frog) RFL33170XF Recombinant Full Length Xenopus Laevis Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Dad1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-113)
Zea mays (Maize) RFL6811ZF Recombinant Full Length Zea Mays Defender Against Cell Death 1(Dad1) Protein, His-Tagged E.coli expression system His Full Length (1-79)
Zebrafish DAD1-5896Z Recombinant Zebrafish DAD1 Mammalian Cell His
Chicken DAD1-1739C Recombinant Chicken DAD1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DAD1 involved in several pathways and played different roles in them. We selected most pathways DAD1 participated on our site, such as Asparagine N-linked glycosylation, Metabolic pathways, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Asparagine N-linked glycosylationMGAT4B;ST6GAL2B;MPDU1A;CNIH;ALG2;NAPAB;LMAN2;MLEC;PPP6C
Metabolic pathwaysACOT2;HPDA;UGT1A6A;CYP2C45;ATP6V0CB;AMPD3B;CDO1;NDUFA4;PLCD1B
Metabolism of proteinsSERPINA7;SLC30A5;PPP6R1;FXC1;PREB;ADAMTS4;GALNTL2;SEC22C;KLHDC3
N-Glycan biosynthesisALG11;MGAT1A;GANAB;MGAT2;MAN1C1;MAN1A1;STT3B;ALG8;B4GALT1
Post-translational protein modificationGALNTL5;NAPAA;TMED10;LMAN2;ADAMTSL3;MPDU1A;GCNT3;B3GALTL;TRAPPC6B
Protein processing in endoplasmic reticulumMBTPS2;EDEM3;RPN2;SEC31A;UBE2J1;MARCH6;DNAJB2;UBE2D1A;BAG1

DAD1 has several biochemical functions, for example, contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity, contributes_to oligosaccharyl transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DAD1 itself. We selected most functions DAD1 had, and list some proteins which have the same functions with DAD1. You can find most of the proteins on our site.

Function Related Protein
contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activityRPN2;STT3A;DAD1;OSTC;DDOST;RPN1;TUSC3
contributes_to oligosaccharyl transferase activityDAD1;DDOST

DAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAD1.

EPB41; HLA-B; IKBKE; q81v76_bacan; P

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