D-amino acid oxidase activator (DAOA, also known as G72) is a protein enriched in various parts of brain, spinal cord, and testis. DAOA is thought to interact with D-amino acid oxidase, a peroxisomal enzyme, and its gene was associated with schizophrenia in a number of studies. In separate studies it has been shown to confer susceptibility to bipolar disorder. Therefore it has been important in researching whether the Kraepelinian dichotomy is genuine. The gene itself was discovered during an investigation of chromosomal 13q22-q34 region, which was previously linked to schizophrenia. G72 is transcribed into several proteins due to alternative splicing; the longest protein is called LG72 and consists of 153 amino acids. Although the protein was initially found to interact with DAO in yeast 2-hybrid experiment, one recent in vivo experiment showed LG72 presence only in mitochondria and failed to confirm the interaction. The expression of DAOA may be regulated by the long non-coding RNA DAOA-AS1.
DAOA has several biochemical functions, for example, enzyme activator activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAOA itself. We selected most functions DAOA had, and list some proteins which have the same functions with DAOA. You can find most of the proteins on our site.
Function enzyme activator activity
Related Protein APOA5; ASAP2; CASP9; MGST2; MMP24; TIMP2; SLX4; ARL1; PSAP; DBF4
Function enzyme binding
Related Protein DHCR24; MAPK8; APOA5; YWHAB; PICK1; CBX3; MAT2B; ACAT1; MARCH6; SCARB2
DAOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAOA here. Most of them are supplied by our site. Hope this information will be useful for your research of DAOA.