dars2
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  • Official Full Name
  • aspartyl-tRNA synthetase 2, mitochondrial
  • Background
  • The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL).
  • Synonyms
  • DARS2; aspartyl-tRNA synthetase 2, mitochondrial; aspartyl-tRNA synthetase, mitochondrial; aspartate tRNA ligase 2; mitochondrial; FLJ10514; Aspartate tRNA ligase; Aspartyl tRNA synthetase 2 (mitochondrial); AspRS; LBSL; MT ASPRS; RP3 383J4.2; aspartate tRNA ligase 2, mitochondrial; MT-ASPRS; RP3-383J4.2
Cat.#:DARS2-2350HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DARS2 Protein, GST-tagged
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Cat.#:DARS2-4310MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DARS2 Protein
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Cat.#:DARS2-1776RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DARS2 Protein
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Cat.#:DARS2-3673BTag:His
Source (Host):Mammalian CellsSpecies:Bovine
Product nameRecombinant Bovine DARS2, His-tagged
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Cat.#:DARS2-7072HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DARS2 293 Cell Lysate
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Involved Pathway

DARS2 involved in several pathways and played different roles in them. We selected most pathways DARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aminoacyl-tRNA biosynthesis
KARS; EARS2; AARS; EPRS; SEPSECS; FARSB; CARS; HARS; DARS2; NARS

Protein Function

DARS2 has several biochemical functions, for example, ATP binding, aspartate-tRNA ligase activity, aspartate-tRNA(Asn) ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DARS2 itself. We selected most functions DARS2 had, and list some proteins which have the same functions with DARS2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CDKL4; EPHA2; MAP3K4; DNAH14; EHD4; MTPAP; ENTPD8; DDX42; PRKCHA; CDK18
Function aspartate-tRNA ligase activity
Related Protein DARS; DARS2
Function aspartate-tRNA(Asn) ligase activity
Related Protein DARS2
Function protein binding
Related Protein CDKN2B; RPL12; TRAF6; ZFP36; C21orf2; ZNF83; BAAT; LCK; ATG14; RGS8
Function protein homodimerization activity
Related Protein ERN1; VAPB; HELT; TERF1; ERBB4; GABPB2; MTERFD3; PPP2R4; C16orf89; SLK
Function tRNA binding
Related Protein PTCD1; RARS; TRMT1L; YARS; EIF2AK4; XPO5; CTU2; FARSA; TERT; NSUN2

Interacting Protein

DARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DARS2.
EPHA8; DPYSL5; ssdna_dtdc; N