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DARS2

  • Official Full Name

    aspartyl-tRNA synthetase 2, mitochondrial

  • Overview

    The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL).
  • Synonyms

    DARS2; aspartyl-tRNA synthetase 2, mitochondrial; aspartyl-tRNA synthetase, mitochondrial; aspartate tRNA ligase 2; mitochondrial; FLJ10514; Aspartate tRNA ligase; Aspartyl tRNA synthetase 2 (mitochondrial); AspRS; LBSL; MT ASPRS; RP3 383J4.2; aspartate tRNA ligase 2, mitochondrial; MT-ASPRS; RP3-383J4.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DARS2-2350H Recombinant Human DARS2 Protein, GST-tagged Wheat Germ GST
Human DARS2-7072HCL Recombinant Human DARS2 293 Cell Lysate HEK293 N/A
Human DARS2-2020H Recombinant Human DARS2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DARS2-2515HF Recombinant Full Length Human DARS2 Protein, GST-tagged In Vitro Cell Free System GST 645 amino acids
Human DARS2-443HFL Recombinant Full Length Human DARS2 Protein, C-Flag-tagged Mammalian cells Flag
Human DARS2-716H Recombinant Human DARS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DARS2-716H-B Recombinant Human DARS2 Protein Pre-coupled Magnetic Beads HEK293
Mouse DARS2-4310M Recombinant Mouse DARS2 Protein Mammalian Cell His
Mouse Dars2-2456M Recombinant Mouse Dars2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Dars2-1313M Recombinant Mouse Dars2 Protein, His-tagged E.coli N-His Ala390-Ser653
Mouse DARS2-2204M-B Recombinant Mouse DARS2 Protein Pre-coupled Magnetic Beads HEK293
Mouse DARS2-2204M Recombinant Mouse DARS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DARS2-1776R Recombinant Rat DARS2 Protein Mammalian Cell His
Rat DARS2-1434R-B Recombinant Rat DARS2 Protein Pre-coupled Magnetic Beads HEK293
Rat DARS2-1434R Recombinant Rat DARS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Dars2-1314R Recombinant Rat Dars2 Protein, His-tagged E.coli N-His Gly442-Ser652
Bovine DARS2-3673B Recombinant Bovine DARS2, His-tagged E.Coli or Yeast His 651
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DARS2 involved in several pathways and played different roles in them. We selected most pathways DARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aminoacyl-tRNA biosynthesisTARSL2;WARS;HARS2;GARS;SARS;FARSA;RARS;PARS2;TARS2

DARS2 has several biochemical functions, for example, ATP binding, aspartate-tRNA ligase activity, aspartate-tRNA(Asn) ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DARS2 itself. We selected most functions DARS2 had, and list some proteins which have the same functions with DARS2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAP2K7;ALDH18A1;ACVR1L;DNAJA1;CLK1;STYK1;CHD1;MTHFD1L;MATK
aspartate-tRNA ligase activityDARS;DARS2
aspartate-tRNA(Asn) ligase activity
protein bindingSPHK1;SLC11A2;SYT1;PTPMT1;TMEM67;YIPF3;KHDRBS3;ZNF576;XAGE3
protein homodimerization activityPVR;DEM1;GRIK1;PEX7;MID2;APOA2;LILRB1;MFF;TRIM5
tRNA bindingXPOT;DARS2;FDXACB1;TYW5;PTCD1;METTL1;TRMT1L;RPL35A;EARS2

DARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DARS2.

EPHA8; DPYSL5; ssdna_dtdc; N

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