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DCAMKL2

Official Full Name

doublecortin-like kinase 2
Overview

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.
Synonyms

DCLK2; doublecortin-like kinase 2; CL2; CLICK2; DCAMKL2; DCDC3; DCDC3B; DCK2; DKFZp761I032; MGC45428; doublecortin and CaM kinase-like 2; EC 2.7.11.1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DCAMKL2-293H	Recombinant Human DCAMKL2, GST-tagged, Active	Sf9 Insect Cell	GST		Inquiry

Involved Pathway
Protein Function
Interacting Protein

DCAMKL2 involved in several pathways and played different roles in them. We selected most pathways DCAMKL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DCAMKL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

DCAMKL2 has several biochemical functions, for example, ATP binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCAMKL2 itself. We selected most functions DCAMKL2 had, and list some proteins which have the same functions with DCAMKL2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	DDX28;PDXK;BSK146;CHUK;CDK13;NLRP10;BUB1B;CHD8;P2RX4B
protein serine/threonine kinase activity	C9orf96;ACVR1L;NLK2;ACVR1BA;BUB1B;HIPK4;NUAK1;GRK1B;NEK5

DCAMKL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCAMKL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCAMKL2.

saicar; PKM; xmd8-92; HSP90AB1; TSC22D3