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DCLK2

  • Official Full Name

    doublecortin-like kinase 2

  • Overview

    This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.
  • Synonyms

    DCLK2; doublecortin-like kinase 2; DCAMKL2, doublecortin and CaM kinase like 2; serine/threonine-protein kinase DCLK2; DCDC3; DCDC3B; DCK2; MGC45428; CaMK-like CREB regulatory kinase 2; CL2; CLICK-II; CLICK2; DCAMK L2; DCAMKL 2; DCDC 3; DCDC 3B; DCK 2; DCLK 2; DCLK2_HUMAN; DKFZp761I032; Doublecortin and CaM kinase like 2; Doublecortin domain-containing protein 3B; Doublecortin like and CAM kinase like 2; Doublecortin like kinase 2; Doublecortin-like and CAM kinase-like 2; Serine/threonine protein kinase DCLK2; OTTHUMP00000220237; OTTHUMP00000220238; OTTHUMP00000220239; OTTHUMP00000220240; doublecortin and CaM kinase-like 2; doublecortin domain-containing; CLIK2; DCAMKL2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DCLK2-53H Active Recombinant Human DCLK2(376-end) Protein, N-His-tagged Sf21 His 376-end
Human DCLK2-2393H Active Recombinant Human DCLK2 Protein, GST-tagged Insect Cell GST
Human DCLK2-26989TH Recombinant Human DCLK2 N/A
Human DCLK2-2394H Recombinant Human DCLK2 Protein, GST-tagged Wheat Germ GST
Human DCLK2-1168H Recombinant Human DCLK2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DCLK2-2880HF Recombinant Full Length Human DCLK2 Protein, GST-tagged In Vitro Cell Free System GST 695 amino acids
Human DCLK2-1318H Recombinant Human DCLK2 Protein, His&GST-tagged E.coli N-His&GST Met1-Cys246
Mouse DCLK2-4351M Recombinant Mouse DCLK2 Protein Mammalian Cell His
Mouse DCLK2-2232M Recombinant Mouse DCLK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DCLK2-2232M-B Recombinant Mouse DCLK2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Dclk2-2474M Recombinant Mouse Dclk2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Dclk2-1319M Recombinant Mouse Dclk2 Protein, His-tagged E.coli N-His Met1-Lys291
Rat DCLK2-1794R Recombinant Rat DCLK2 Protein Mammalian Cell His
Rat DCLK2-1452R-B Recombinant Rat DCLK2 Protein Pre-coupled Magnetic Beads HEK293
Rat DCLK2-1452R Recombinant Rat DCLK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DCLK2-7393Z Recombinant Zebrafish DCLK2 Mammalian Cell His
Zebrafish DCLK2-7391Z Recombinant Zebrafish DCLK2 Mammalian Cell His
Zebrafish DCLK2-7182Z Recombinant Zebrafish DCLK2 Mammalian Cell His
Zebrafish DCLK2-7392Z Recombinant Zebrafish DCLK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DCLK2 involved in several pathways and played different roles in them. We selected most pathways DCLK2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DCLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DCLK2 has several biochemical functions, for example, ATP binding, kinase activity, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCLK2 itself. We selected most functions DCLK2 had, and list some proteins which have the same functions with DCLK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingOAS1;KIF15;KIFC1;IARS;TARS;MAP3K15;MAPK9;UBE2E3;MAPK14
kinase activityPRKAB1A;AGPHD1;ERBB3A;CDK5R1B;TRIOA;PKMB;PIP5K2;PANK1A;MAP2K4B
nucleotide bindingCSNK1DA;CLCN6;RABL2;RAD51L1;DNAJC17;EPHA2A;REV3L;PEO1;TOR1L3
protein kinase activityTSSK5;PDPK1A;SBK3;PKZ;PRKCD;EK1;CAMK1DB;MAP2K5;EEF2K
protein serine/threonine kinase activitySRPK3;MARK3;TNIK;DCAMKL2;MAPK1;PDK3;MAP3K12;DSTYK;MAP2K1
transferase activityPOLE2;EPHB4B;DGAT1A;CHST12A;PRDM9;PRKCBB;UGT5G1;GNPTAB;MKNK2A

DCLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCLK2.

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