dcn
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  • Official Full Name
  • decorin
  • Background
  • The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DCN; decorin; CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II
Cat.#:DCN-1170HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DCN Protein, MYC/DDK-tagged
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Cat.#:DCN-2398HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DCN Protein, GST-tagged
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Cat.#:DCN-311HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DCN Protein, His-tagged
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Cat.#:DCN-1600HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Decorin
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Cat.#:DCN-1702HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Decorin, HIgG1 Fc-tagged
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Cat.#:DCN-3348HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human DCN, His tagged
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Cat.#:DCN-57HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human DCN protein, His-tagged
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Cat.#:DCN-73HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human DCN, Fc tagged
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Cat.#:DCN-82HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DCN protein, T7/His-tagged
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Cat.#:DCN-901HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Decorin, His-tagged
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Cat.#:Dcn-1887MTag:His
Source (Host):NSOSpecies:Mouse
Product nameRecombinant Mouse Dcn protein, His-tagged
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Cat.#:DCN-4355MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DCN Protein
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Cat.#:Dcn-64MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Dcn protein, His-tagged
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Cat.#:DCN-1797RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DCN Protein
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Cat.#:DCN-2448CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DCN
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Cat.#:DCN-9222ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DCN
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Cat.#:DCN-2274HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human DCN cell lysate
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Involved Pathway

DCN involved in several pathways and played different roles in them. We selected most pathways DCN participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis, CS/DS degradation, Chondroitin sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCN were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
A tetrasaccharide linker sequence is required for GAG synthesis
DCN; BGNB; GPC6; VCANB; Gpc2; GPC1A; CSPG5B; BGNA; GPC1B; B3GAT2
CS/DS degradation
DCN; CSPG5B; BCAN; CSPG5; CSPG4; VCANB; BGN; VCAN; NCAN; BGNB
Chondroitin sulfate biosynthesis
VCANB; CSPG5; CSPG5B; UST; B3GAT2; VCAN; BGNB; BGNA; CSPG4; BCAN
Chondroitin sulfate/dermatan sulfate metabolism
GPC1B; GPC1A; B4GALT7; NCAN; GPC5A; CSPG4; DSEL; CHST14; BCAN; BGNA
Defective B3GALT6 causes EDSP2 and SEMDJL1
GPC6; BCAN; CSPG5; DCN; VCAN; NCAN; CSPG4; BGN; GPC5; AGRN
Defective B3GAT3 causes JDSSDHD
GPC6; AGRN; VCAN; CSPG4; CSPG5; DCN; BGN; NCAN; BCAN; GPC5
Defective B4GALT7 causes EDS, progeroid type
AGRN; BGN; NCAN; BCAN; CSPG5; CSPG4; GPC6; GPC5; VCAN; DCN
Defective CHST14 causes EDS, musculocontractural type
BCAN; DCN; BGN; CSPG5; CSPG4

Protein Function

DCN has several biochemical functions, for example, collagen binding, extracellular matrix binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCN itself. We selected most functions DCN had, and list some proteins which have the same functions with DCN. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein ASPN; ITGA2; TGFBI; MMP9; USH2A; ABI3BP; COMP; PCOLCE2; MMP13; SRGN
Function extracellular matrix binding
Related Protein GPR56; VTN; CYR61; ITGAV; SPOCK2; BGN; ITGA2B; TGFBI; CD248; SID4
Function glycosaminoglycan binding
Related Protein SPOCK2; TGFBR2; TGFBR3; SPOCK3; EGFLAM; VIT; SERPINE2; SERPINA5; CCDC80; VCAN
Function poly(A) RNA binding
Related Protein RPL35A; RC3H2; ZC3H15; ZC3H8; HIST1H1B; RPS28; HIST1H4H; MTAP4; RBM14; HRSP12
Function protein N-terminus binding
Related Protein STX5; CSNK2A2; ERCC2; STXBP1; THAP7; SLC6A3; TGFB1; MAU2; SYNGR3; SMARCE1

Interacting Protein

DCN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCN here. Most of them are supplied by our site. Hope this information will be useful for your research of DCN.
INS; INS; IGF2; INSR; FGF2; Fgf7; Fgf8; Fgf1

DCN Related Articles

Hamodeh, S; Baizer, J; et al. Systematic Analysis of Neuronal Wiring of the Rodent Deep Cerebellar Nuclei Reveals Differences Reflecting Adaptations at the Neuronal Circuit and Internuclear Levels. JOURNAL OF COMPARATIVE NEUROLOGY 522:2481-2497(2014).
Dupuis, LE; Kern, CB; et al. Small Leucine- Rich Proteoglycans Exhibit Unique Spatiotemporal Expression Profiles During Cardiac Valve Development. DEVELOPMENTAL DYNAMICS 243:601-611(2014).